ALDH1A1 Cancer Research Results

ALDH1A1, Aldehyde Dehydrogenase 1A1: Click to Expand ⟱

Source:

Type: Protein-coding gene

(ALDH1A1) is a cancer stem cell marker, and its expression correlates with prognosis in a number of malignancies. Aldehyde dehydrogenases are the cancer stem cells which plays a role in CSC progression. ALDH comprise 19 subfamilies in which ALDH1A1, ALDH1A3, ALDH3A1, ALDH5A1, ALDH7A1, and ALDH18A1 are implicated in CSC. Existing chemotherapeutic drugs eliminate the bulk of tumors but are usually not effective against CSC which express ALDH+ population. Henceforth, targeting ALDH is convincing to treat the patient's post-relapse.

Melanoma, Melanoma Skin Cancer: Click to Expand ⟱

Melanoma is a rare form of skin cancer. It is more likely to invade nearby tissues and spread to other parts of the body than other types of skin cancer.

Scientific Papers found: Click to Expand⟱

1060-

LT,

BTZ,

Luteolin inhibits the TGF-β signaling pathway to overcome bortezomib resistance in multiple myeloma

vitro+vivo,

Melanoma,

ALDH1A1↓, TGF-β↓, ChemoSen↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,

Migration ⓘ

TGF-β↓, 1,

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: ALDH1A1, Aldehyde Dehydrogenase 1A1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells