BMI1 Cancer Research Results

BMI1, B cell-specific Moloney murine leukemia virus integration site 1: Click to Expand ⟱

Source:

Type:

BMI1 (B cell-specific Moloney murine leukemia virus integration site 1) is a protein that plays a crucial role in the regulation of cell growth, differentiation, and survival. It is a key component of the Polycomb repressive complex 1 (PRC1), which is involved in the silencing of genes through histone modification.
Overexpression of BMI1 has been observed in many types of cancer, and it is often associated with poor prognosis and reduced survival rates.

Melanoma, Melanoma Skin Cancer: Click to Expand ⟱

Melanoma is a rare form of skin cancer. It is more likely to invade nearby tissues and spread to other parts of the body than other types of skin cancer.

Scientific Papers found: Click to Expand⟱

5437-

AG,

Modulation of PD-L1 by Astragalus polysaccharide attenuates the induction of melanoma stem cell properties and overcomes immune evasion

in-vivo,

Melanoma,

B16-F10

mice

CSCs↓, CD133↓, BMI1↓, PD-L1↓, TumCG↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State ⓘ

BMI1↓, 1, CD133↓, 1, CSCs↓, 1, TumCG↓, 1,

Immune & Inflammatory Signaling ⓘ

PD-L1↓, 1,

Clinical Biomarkers ⓘ

PD-L1↓, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: BMI1, B cell-specific Moloney murine leukemia virus integration site 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells