p50 Cancer Research Results

p50, p50: Click to Expand ⟱
Source:
Type:
p50 is a protein that is part of the NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) transcription factor complex. NF-κB is a key regulator of immune responses, inflammation, and cell survival, and it plays a critical role in the development and progression of various types of cancer.
p50 is one of the two subunits of the NF-κB complex, the other being p65. The p50/p65 heterodimer is the most common form of NF-κB, and it is activated by a wide range of stimuli, including cytokines, growth factors, and stress.
In cancer, p50 is often overexpressed or constitutively activated, leading to the promotion of cell proliferation, survival, and metastasis.
Melanoma, Melanoma Skin Cancer: Click to Expand ⟱
Melanoma is a rare form of skin cancer. It is more likely to invade nearby tissues and spread to other parts of the body than other types of skin cancer.
Scientific Papers found: Click to Expand⟱
5210- PI,    Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells
- in-vitro, Melanoma, B16-BL6
IL1β↓, TNF-α↓, MMPs↓, p65↓, p50↓, NF-kB↓, ATF2↓, cFos↓, CREB↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

CREB↓, 1,  

Cell Death ⓘ

ATF2↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

cFos↓, 1,  

Migration ⓘ

MMPs↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   NF-kB↓, 1,   p50↓, 1,   p65↓, 1,   TNF-α↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: p50, p50
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:39  Cells:%  prod#:%  Target#:842  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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