EPR Cancer Research Results
EPR, enhanced permeability and retention (EPR) effect: Click to Expand ⟱
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Passive accumulation (in cells) is based on the unique architecture of the tumor tissue, where neo-angiogenesis leads to an atypical endothelial layer and to fenestrated vasculature, which together with the impaired lymphatic drainage guides the penetration and accumulation of nano-sized materials within the cancerous tissues.
Exploited for drug design in the nanomedicine field.
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Melanoma, Melanoma Skin Cancer: Click to Expand ⟱
Melanoma is a rare form of skin cancer. It is more likely to invade nearby tissues and spread to other parts of the body than other types of skin cancer.
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Scientific Papers found: Click to Expand⟱
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in-vivo, |
Melanoma, |
B16-F10 |
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Dose↝, TumCG↓, TumCP↓, BioAv↓, BioAv↑, other↑, Apoptosis↑, Bax:Bcl2↑, EPR↑, toxicity↝,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Cell Death ⓘ
Apoptosis↑, 1, Bax:Bcl2↑, 1,
Transcription & Epigenetics ⓘ
other↑, 1,
Proliferation, Differentiation & Cell State ⓘ
TumCG↓, 1,
Migration ⓘ
TumCP↓, 1,
Angiogenesis & Vasculature ⓘ
EPR↑, 1,
Drug Metabolism & Resistance ⓘ
BioAv↓, 1, BioAv↑, 1, Dose↝, 1,
Functional Outcomes ⓘ
toxicity↝, 1,
Total Targets: 10
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: EPR, enhanced permeability and retention (EPR) effect
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:39 Cells:% prod#:% Target#:612 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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