FEN1 Cancer Research Results

FEN1, flap endonuclease 1: Click to Expand ⟱
Source:
Type:
FEN1 Flap endonuclease 1 DNA replication and repair Up Structure-specific nuclease involved in Okazaki-fragment maturation, long-patch base-excision repair and replication-fork processing. FEN1 is frequently overexpressed in cancer and can promote tumour-cell proliferation, DNA-damage repair and treatment resistance. Therapeutic inhibition or downregulation increases replication stress and DNA damage, suppresses proliferation and may produce synthetic lethality in homologous-recombination-deficient cancers.


BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
7412- CS,  Chemo,    Artichoke Polyphenols Sensitize Human Breast Cancer Cells to Chemotherapeutic Drugs via a ROS-Mediated Downregulation of Flap Endonuclease 1
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Apoptosis↑, ROS↑, TumCP↓, DNAdam↑, FEN1↓, ChemoSen↑, NRF2↑,
7037- GA,  Chit,    Gallic acid-loaded chitosan nanoparticles enhance the DNA damage and apoptotic features through inhibiting flap endonuclease-1 in triple-negative breast cancer cells
- in-vitro, BC, MDA-MB-231
DNAdam↑, Apoptosis↑, FEN1↓, selectivity↑, ROS↑, DNAdam↑, PARP1↑, TumCP↓, p‑PI3K↓, Akt↓, cycD1/CCND1↓, BAX↑, Casp3↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

FEN1↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↑, 1,   ROS↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 2,   BAX↑, 1,   Casp3↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   PARP1↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑PI3K↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   selectivity↑, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: FEN1, flap endonuclease 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:1567  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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