LATS1 Cancer Research Results

LATS1, Large Tumor Suppressor Kinase 1: Click to Expand ⟱
Source:
Type:

LATS1 - Large Tumor Suppressor Kinase 1

Type: Serine/threonine protein kinase / Hippo pathway tumor suppressor

Function: Core kinase of the Hippo signaling pathway that phosphorylates and inhibits the transcriptional co-activators YAP and TAZ, promoting their cytoplasmic retention and degradation. LATS1 regulates cell proliferation, apoptosis, cell-cycle progression, tissue growth, contact inhibition, and genome stability.

Cancer: ↓ Frequently reduced, inhibited, or functionally inactivated in cancer. Loss of LATS1 activity permits increased YAP/TAZ transcriptional activity, promoting proliferation, survival, invasion, stemness, metastasis, and tumor progression. Restoration or activation of LATS1 generally suppresses oncogenic YAP/TAZ signaling.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
7375- RS,    Regulation of hippo signaling mediated apoptosis by Rauvolfia tetraphylla in triple-negative breast cancer
- in-vitro, BC, MDA-MB-231
eff↝, TumCCA↑, TumCMig↓, ROS↑, BAX↑, Mst1↑, Bcl-2↓, YAP/TEAD↓, LATS1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

LATS1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   Bcl-2↓, 1,   YAP/TEAD↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Mst1↑, 1,  

Migration(tgid=13) ⓘ

TumCMig↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↝, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LATS1, Large Tumor Suppressor Kinase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:1630  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page