NF-kB Cancer Research Results

NF-kB, Nuclear factor kappa B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
NF-kB signaling
Nuclear factor kappa B (NF-κB) is a transcription factor that plays a crucial role in regulating immune response, inflammation, cell proliferation, and survival.
NF-κB is often found to be constitutively active in many types of cancer cells. This persistent activation can promote tumorigenesis by enhancing cell survival, proliferation, and metastasis.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
1594- AgNPs,  Citrate,    Silver Citrate Nanoparticles Inhibit PMA-Induced TNFα Expression via Deactivation of NF-κB Activity in Human Cancer Cell-Lines, MCF-7
- in-vitro, BC, MCF7
TNF-α↓, NF-kB↓, antiOx↑, TumCP↓,
389- AgNPs,  Citrate,    Silver Citrate Nanoparticles Inhibit PMA-Induced TNFα Expression via Deactivation of NF-κB Activity in Human Cancer Cell-Lines, MCF-7
- in-vitro, BC, MCF7
TNF-α↓, NF-kB↓,
253- AL,    Allicin inhibits invasion and migration of breast cancer cells through the suppression of VCAM-1: Regulation of association between p65 and ER-α
- in-vitro, BC, MDA-MB-231
TumCMig↓, ERK↓, VCAM-1↓, NF-kB↓,
1078- And,    Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs - in-vivo, BC, MCF7 - in-vitro, BC, T47D - in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-361
TumCP↓, COX2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,
1142- Ash,    Ashwagandha-Induced Programmed Cell Death in the Treatment of Breast Cancer
- Review, BC, MCF7 - NA, BC, MDA-MB-231 - NA, Nor, HMEC
Apoptosis↑, ROS↑, DNAdam↑, OXPHOS↓, *ROS∅, Bcl-2↓, XIAP↓, survivin↓, DR5↑, IKKα↓, NF-kB↓, selectivity↑, *ROS∅, eff↓, Paraptosis↑,
4810- ASTX,    Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCP↓, TumCMig↓, selectivity↑, *BDNF↑, *ROS↓, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓, BAX⇅, Bcl-2↓, *antiOx↑, radioP↑, ChemoSen↑,
1053- Ba,  docx,    Baicalin, a Potent Inhibitor of NF-κB Signaling Pathway, Enhances Chemosensitivity of Breast Cancer Cells to Docetaxel and Inhibits Tumor Growth and Metastasis Both In Vitro and In Vivo
- in-vivo, BC, 4T1
TumCP↓, Apoptosis↑, ROS↑, Bax:Bcl2↑, NF-kB↓, ChemoSen↑, survivin↓,
2599- Ba,    Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
TumCP↓, Apoptosis↑, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IKKα↓, IKKα↑, PI3K↓, MMP↓, TumAuto↑, TumVol↓, TumW↓,
2727- BetA,    Betulinic acid in the treatment of breast cancer: Application and mechanism progress
- Review, BC, NA
mt-ROS↑, Sp1/3/4↓, TumMeta↓, GlucoseCon↓, NF-kB↓, ChemoSen↑, chemoP↑, m-Apoptosis↑, TOP1↓,
2755- BetA,    Cytotoxic Potential of Betulinic Acid Fatty Esters and Their Liposomal Formulations: Targeting Breast, Colon, and Lung Cancer Cell Lines
- in-vitro, Colon, HT29 - in-vitro, BC, MCF7 - in-vitro, Lung, H460
eff↑, Casp3↑, Casp7↑, NF-kB↓,
2774- Bos,    Boswellia ovalifoliolata abrogates ROS mediated NF-κB activation, causes apoptosis and chemosensitization in Triple Negative Breast Cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-453
ChemoSen↑, Casp3↑, ROS↓, NF-kB↓,
1423- Bos,    Acetyl-11-keto-β-Boswellic Acid Suppresses Invasion of Pancreatic Cancer Cells Through The Downregulation of CXCR4 Chemokine Receptor Expression
- in-vitro, Melanoma, U266 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3 - in-vitro, PC, PANC1
CXCR4↓, TumCI↓, HER2/EBBR2↓, NF-kB↓,
6559- BSB,    NF-kBAktPI3K_Signaling_pathways_in_MCF-7_breast_cancer_cells">Modulatory effect of α-Bisabolol on induced apoptosis via mitochondrial and NF-κB/Akt/PI3K Signaling pathways in MCF-7 breast cancer cells
- in-vitro, BC, MCF7
TumCG↓, TumCP↓, Apoptosis↓, ROS↑, Bcl-2↓, BAX↑, BAD↑, Casp3↑, Casp9↑, Cyt‑c↑, NF-kB↓, p‑PI3K↓, p‑Akt↓,
5749- CA,  Z,  Rad,    Antitumor and Radiosensitizing Effects of Zinc Oxide-Caffeic Acid Nanoparticles against Solid Ehrlich Carcinoma in Female Mice
- vitro+vivo, BC, MCF7 - NA, Liver, HepG2
RadioS↑, TumVol↓, Bcl-2↓, NF-kB↓, VCAM-1↓, ERK↓, DNAdam↑, TumCCA↑,
5764- CAPE,    Caffeic Acid Phenethyl Ester (CAPE), Derived from a Honeybee Product Propolis, Exhibits a Diversity of Anti-tumor Effects in Preclinical Models of Human Breast Cancer
- vitro+vivo, BC, MCF7 - NA, BC, MDA-MB-231
TumCG↓, TumCCA↑, Apoptosis↑, NF-kB↓, MDR1↓, VEGF↓, angioG↓,
5897- CAR,    Carvacrol Selectively Induces Mitochondria-Related Apoptotic Signaling in Primary Breast Cancer-Associated Fibroblasts
- in-vitro, BC, NA
Bax:Bcl2↑, PPARα↓, NF-kB↓, SIRT1↑, SIRT3↑, MMP3↓, selectivity↑, Bcl-2↓, BAX↑, Casp3↑, Casp6↑, Casp9↑, mt-Apoptosis↑,
6641- Cen,    Asiaticoside Increases Caspase-9 Activity in MCF-7 Cells and Inhibits TNF-α and IL-6 Expression in Nude Mouse Xenografts via the NF-κB Pathway
- in-vitro, BC, MCF7
Casp9↑, TNF-α↓, IL6↓, NF-kB↓, TumCG↓, Inflam↓, TumCP↓, EMT↓,
6006- CGA,    Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF-κB signaling pathway
- in-vitro, BC, NA
NF-kB↓, AntiTum↑, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓,
6030- CGA,    Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF‑κB signaling pathway
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-453 - in-vitro, Nor, MCF10
NF-kB↓, AntiTum↑, tumCV↓, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, TumCG↓, OS↑, TumMeta↓, CD4+↑, CD8+↑, Imm↑,
6304- Cro,    Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ
- in-vitro, BC, NA
NF-kB↓, tumCV↓, TumCP↓, TNF-α↓, IL1β↓, Inflam↓, PRKCQ/PKCθ↓,
4652- CUR,    Anticancer effect of curcumin on breast cancer and stem cells
- Review, BC, NA
TumCP↓, TumMeta↓, TumCCA↑, Apoptosis↑, CSCs↓, NF-kB↓, Telomerase↓, Cyt‑c↑, Casp9↑, Casp3↑, E-cadherin↑,
4656- CUR,  EGCG,    Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFκB signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
CSCs↓, CD44↓, p‑STAT3↓, NF-kB↓, TumCI↓,
424- CUR,    Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-κB signaling and polyamine metabolism in breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Src↓, p‑STAT1↓, p‑Akt↓, p‑p44↓, p‑p42↓, RAS↓, Raf↓, Vim↓, β-catenin/ZEB1↓, P53↓, Bcl-2↓, Mcl-1↓, PIAS-3↑, SOCS-3↑, SOCS1↑, ROS↑, NF-kB↓, PAO↑, SSAT↑, P21↑, Bak↑,
161- CUR,  MeSA,    Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: potential role of Mcl-1 and FAK
- in-vitro, BC, MDA-MB-231 - in-vitro, Pca, DU145
Mcl-1↑, Mcl-1↓, MPT↑, AIF↑, chemoPv↑, Apoptosis↑, ROS↑, FAK↓, STAT3↓, NF-kB↓,
13- CUR,    Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
- Review, BC, NA
P53↑, DR5↑, JNK↑, NRF2↑, PPARγ↑, HER2/EBBR2↓, IR↓, ER(estro)↓, Fas↑, PDGF↓, TGF-β↓, FGF↓, EGFR↓, JAK↓, PAK↓, MAPK↓, ATPase↓, COX2↓, MMPs↓, IL1↓, IL2↓, IL5↓, IL6↓, IL8↓, IL12↓, IL18↓, NF-kB↓, NOTCH1↓, STAT1↓, STAT4↓, STAT5↓, STAT3↓,
6246- Cyc,    Cyclopamine is a novel Hedgehog signaling inhibitor with significant anti-proliferative, anti-invasive and anti-estrogenic potency in human breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
HH↓, TumCP↓, TumCCA↓, TumCI↓, NF-kB↓, MMP2↓, MMP9↓, ERα/ESR1↓, cycD1/CCND1↓,
1443- Deg,    Deguelin Action Involves c-Met and EGFR Signaling Pathways in Triple Negative Breast Cancer Cells
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-435 - in-vitro, BC, BT549
EGFR↓, Akt↓, p‑ERK↓, NF-kB↓, p‑STAT3↓, survivin↓, Myc↓, TumCG↓, cMET↓,
6748- DHA,    Docosahexaenoic acid enrichment of tumor phospholipid membranes increases tumor necroptosis in mice bearing triple negative breast cancer patient-derived xenografts
- in-vivo, BC, NA
TumCG↓, ChemoSen↑, NF-kB↓,
6729- Dipy,    Dipyridamole prevents triple-negative breast-cancer progression
- Trial, BC, MDA-MB-231
TumCG↓, TumMeta↑, β-catenin/ZEB1↓, *AntiAg↑, TumCCA↑, Wnt↓, NF-kB↓,
6744- DSF,    Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, T47D
TumCD↑, ChemoSen↑, BAX↑, Apoptosis↑, CSCs↓, ROS↑, eff↝, JNK↑, p38↑, NF-kB↓,
1618- EA,    A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action
- Review, BC, NA
TumCCA↑, TumCMig↓, TumCI↓, TumMeta↓, Apoptosis↑, TGF-β↓, SMAD3↓, CDK6↓, PI3K↓, Akt↓, angioG↓, VEGFR2/KDR/Flk1↓, MAPK↓, NEDD9↓, NF-kB↓, eff↑, eff↑, RadioS↑, ChemoSen↑, DNAdam↑, eff↑, *toxicity∅, *toxicity∅,
1056- EGCG,    EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1α and NFκB, and VEGF expression
- vitro+vivo, BC, E0771
TumW↓, VEGF↓, Weight∅, Hif1a↓, NF-kB↓,
6384- Eug,    Eugenol modulates the NOD1-NF-κB signaling pathway via targeting NF-κB protein in triple-negative breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-453
TumCG↓, TumMeta↓, NF-kB↓,
6337- Eug,    Eugenol alleviated breast precancerous lesions through HER2/PI3K-AKT pathway-induced cell apoptosis and S-phase arrest
- in-vitro, BC, MCF-10AT
TumCP↓, TumCCA↑, HER2/EBBR2↓, Akt↓, PDK1↓, Bcl-2↓, NF-kB↓, BAD↓, cycD1/CCND1↓,
6340- Eug,    Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulation
- in-vitro, BC, MCF7 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
tumCV↓, E2Fs↓, survivin↓, NF-kB↓, cycD1/CCND1↓, P21↑, TumCP↓, Apoptosis↑, TumCI↓, angioG↓,
2850- FIS,    Fisetin regulates TPA-induced breast Cancer cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways
- in-vitro, BC, MCF7
TumCI↓, PKCδ↓, ROS↓, ERK↑, p38↓, NF-kB↓, MMP9↓,
7089- GAR,    Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Pca, DU145 - in-vitro, PC, NA
STAT3↓, TumCI↓, NF-kB↓, uPA↓, VEGF↓, MMP9↓,
800- GAR,    Garcinol Regulates EMT and Wnt Signaling Pathways In Vitro and In Vivo, Leading to Anticancer Activity against Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
EMT↓, MET↑, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↑, miR-200c↑, Let-7↑, p‑β-catenin/ZEB1↓, NF-kB↓,
799- GAR,    Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, NMSC, MCF10
TumCG↓, Apoptosis↑, NF-kB↓,
798- GAR,    Garcinol, an acetyltransferase inhibitor, suppresses proliferation of breast cancer cell line MCF-7 promoted by 17β-estradiol
- in-vitro, BC, MCF7
TumCP↓, TumCCA↑, Apoptosis↑, ac‑H3↑, ac‑H4∅, NF-kB↓, ac‑p65↑, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓,
7224- GAs,    Ginkgolic acids inhibit migration in breast cancer cells by inhibition of NEMO sumoylation and NF-κB activity
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Wound Healing↓, uPA↓, PAI-1/SERPINE1↓, CXCR4↓, MMP9↓, TumCMig↓, NF-kB↓,
7468- HNK,    Honokiol and Its Emerging Role in Breast Cancer Therapy
- Review, BC, NA
*ROS↓, *Inflam↓, CSCs↓, ChemoSen↑, BioAv↑, ROS↑, MMP↓, mtDam↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, BAX↑, p‑STAT3↓, AMPK↑, miR-34a↑, EMT↓, HH↓, Shh↓, Gli1↓, PTCH1↓, NF-kB↓, TNF-α↓, IL6↓, Glycolysis↓, GlucoseCon↓, BioAv↓, BioAv↓, Half-Life↝,
4795- Lyco,    Updates on the Anticancer Profile of Lycopene and its Probable Mechanism against Breast and Gynecological Cancer
- Review, BC, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↝, BAX↝, cycD1/CCND1↓, ERK↓, Akt↓, STAT3↓, NRF2↝, NF-kB↓, ITGB1↓, ITGA5↓, FAK↓, MMP9↓, EMT↓,
1130- OA,    Oroxylin A Suppresses the Cell Proliferation, Migration, and EMT via NF-κB Signaling Pathway in Human Breast Cancer Cells
- in-vitro, BC, MDA-MB-231
TumCP↓, TumCI↓, TumCMig↓, E-cadherin↑, N-cadherin↓, Vim↓, NF-kB↓,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, eff↑, hTERT/TERT↓, cycD1/CCND1↓, eff↑, eff↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1684- PBG,    Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs
Apoptosis?, ANXA7↑, ROS↑, NF-kB↓, MMP↓, selectivity↑,
1685- PBG,    Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells
- in-vitro, BC, MCF7
ANXA7↑, ROS↑, NF-kB↓, MMP↓, selectivity↑, Dose⇅, ROS⇅,
1231- PBG,    Caffeic acid phenethyl ester inhibits MDA-MB-231 cell proliferation in inflammatory microenvironment by suppressing glycolysis and lipid metabolism
- in-vitro, BC, MDA-MB-231
TumCP↓, TumCMig↓, TumCI↓, MMP↓, TLR4↓, TNF-α↓, NF-kB↓, IL1β↓, IL6↓, IRAK4↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDHA↓, ACC↓, FASN↓, eff↓,
4936- PEITC,    PEITC treatment suppresses myeloid derived tumor suppressor cells to inhibit breast tumor growth
- in-vivo, BC, MDA-MB-231
TumCG↓, CD34↓, CD11b↓, CSCs↓, ALC∅, CD4+↓, NF-kB↓, STAT3↓, Hif1a↓,
2957- PL,    Piperlongumine Induces Cell Cycle Arrest via Reactive Oxygen Species Accumulation and IKKβ Suppression in Human Breast Cancer Cells
- in-vitro, BC, MCF7
TumCP↓, TumCMig↓, TumCCA↑, ROS↑, H2O2↑, GSH↓, IKKα↓, NF-kB↓, P21↑, eff↓,

Showing Research Papers: 1 to 50 of 62
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 62

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

PRKCQ/PKCθ↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   GSH↓, 1,   H2O2↑, 1,   NRF2↑, 1,   NRF2↝, 1,   OXPHOS↓, 1,   PAO↑, 1,   ROS↓, 2,   ROS↑, 15,   ROS⇅, 1,   mt-ROS↑, 1,   SIRT3↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 6,   MPT↑, 1,   mtDam↑, 3,   OCR↓, 1,   p‑p42↓, 1,   Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   AMPK↑, 1,   ANXA7↑, 2,   FASN↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 2,   HK2↓, 2,   IR↓, 1,   LDH↓, 3,   LDHA↓, 1,   PDK1↓, 1,   PFK↓, 2,   PKM2↓, 2,   PPARα↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,   SSAT↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 4,   p‑Akt↓, 3,   Apoptosis?, 2,   Apoptosis↓, 1,   Apoptosis↑, 15,   m-Apoptosis↑, 1,   mt-Apoptosis↑, 1,   BAD↓, 1,   BAD↑, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 4,   BAX⇅, 1,   BAX↝, 1,   Bax:Bcl2↑, 3,   Bcl-2↓, 9,   Bcl-xL↓, 2,   Casp3↓, 1,   Casp3↑, 6,   cl‑Casp3↑, 1,   Casp6↑, 1,   Casp7↑, 1,   Casp9↑, 5,   cl‑Casp9↑, 1,   Cyt‑c↑, 3,   DR5↑, 2,   Fas↑, 1,   hTERT/TERT↓, 1,   iNOS↑, 1,   JNK↑, 2,   MAPK↓, 2,   Mcl-1↓, 2,   Mcl-1↑, 1,   Myc↓, 1,   p38↓, 1,   p38↑, 1,   Paraptosis↑, 1,   survivin↓, 4,   Telomerase↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 3,   PAK↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ac‑H3↑, 1,   ac‑H4∅, 1,   HATs↓, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↑, 1,   p62↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   P53↓, 1,   P53↑, 1,   P53↝, 1,   TP53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 7,   E2Fs↓, 1,   P21↓, 1,   P21↑, 4,   TumCCA↓, 1,   TumCCA↑, 10,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD34↓, 1,   CD44↓, 1,   cFos↓, 1,   cMET↓, 1,   CREB2↓, 1,   CSCs↓, 5,   EMT↓, 6,   ERK↓, 3,   ERK↑, 1,   p‑ERK↓, 1,   FGF↓, 1,   Gli1↓, 1,   HDAC8↓, 1,   HH↓, 2,   Let-7↑, 1,   miR-34a↑, 1,   p‑mTOR↓, 1,   NOTCH1↓, 1,   PI3K↓, 2,   p‑PI3K↓, 1,   PIAS-3↑, 1,   PTCH1↓, 1,   RAS↓, 1,   Shh↓, 1,   Src↓, 1,   STAT1↓, 1,   p‑STAT1↓, 1,   STAT3↓, 6,   p‑STAT3↓, 3,   STAT4↓, 1,   STAT5↓, 1,   TOP1↓, 1,   TumCG↓, 11,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

ATPase↓, 1,   CD11b↓, 1,   E-cadherin↑, 3,   FAK↓, 2,   ITGA5↓, 1,   ITGB1↓, 1,   MET↑, 1,   miR-200c↑, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 5,   MMPs↓, 1,   N-cadherin↓, 1,   NEDD9↓, 1,   p‑p44↓, 1,   PAI-1/SERPINE1↓, 1,   PDGF↓, 1,   PKCδ↓, 1,   SMAD3↓, 1,   TGF-β↓, 2,   TIMP1↓, 1,   TumCI↓, 11,   TumCMig↓, 9,   TumCP↓, 17,   TumMeta↓, 5,   TumMeta↑, 1,   uPA↓, 2,   VCAM-1↓, 2,   Vim↓, 3,   Zeb1↓, 1,   ZEB2↑, 1,   β-catenin/ZEB1↓, 2,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   EGFR↓, 2,   eNOS↑, 1,   Hif1a↓, 2,   VEGF↓, 3,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   GLUT3↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   CD4+↑, 1,   COX2↓, 2,   CXCR4↓, 2,   IKKα↓, 2,   IKKα↑, 1,   p‑IKKα↓, 1,   IL1↓, 1,   IL10↓, 2,   IL12↓, 1,   IL18↓, 1,   IL1β↓, 2,   IL2↓, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 4,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 3,   IRAK4↓, 1,   JAK↓, 1,   NF-kB↓, 49,   p65↓, 1,   ac‑p65↑, 1,   SOCS-3↑, 1,   SOCS1↑, 1,   TLR4↓, 2,   TNF-α↓, 6,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 8,   Dose⇅, 1,   Dose∅, 2,   eff↓, 3,   eff↑, 11,   eff↝, 1,   Half-Life↝, 1,   MDR1↓, 1,   RadioS↑, 3,   selectivity↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALC∅, 1,   EGFR↓, 2,   ERα/ESR1↓, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 1,   IL6↓, 4,   LDH↓, 3,   Myc↓, 1,   TP53↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 2,   chemoP↑, 1,   chemoPv↑, 1,   OS↑, 2,   radioP↑, 1,   TumVol↓, 2,   TumW↓, 2,   Weight∅, 1,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 241

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ROS↓, 2,   ROS∅, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IFN-γ↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,   toxicity∅, 2,  
Total Targets: 14

Scientific Paper Hit Count for: NF-kB, Nuclear factor kappa B
5 Curcumin
4 Garcinol
4 Propolis -bee glue
3 Eugenol
2 Silver-NanoParticles
2 Citric Acid
2 Baicalein
2 Docetaxel
2 Betulinic acid
2 Boswellia (frankincense)
2 Chlorogenic acid
2 EGCG (Epigallocatechin Gallate)
2 Pterostilbene
2 Thymoquinone
1 Allicin (mainly Garlic)
1 Andrographis
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 α-Bisabolol / Chamomile oil
1 Caffeic acid
1 Zinc
1 Radiotherapy/Radiation
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carvacrol
1 Centella asiatica / Gotu kola → asiaticoside
1 Crocetin
1 methylseleninic acid
1 Cyclopamine
1 Deguelin
1 Docosahexaenoic Acid
1 Dipyridamole
1 Disulfiram
1 Ellagic acid
1 Fisetin
1 Ginkgolic acids
1 Honokiol
1 Lycopene
1 Oroxylin A
1 Phenethyl isothiocyanate
1 Piperlongumine
1 Quercetin
1 Resveratrol
1 salinomycin
1 Sanguinarine
1 Sulforaphane (mainly Broccoli)
1 Paclitaxel/Taxol
1 Shikonin
1 Selenite (Sodium)
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:214  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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