PAK1 Cancer Research Results

PAK1, : Click to Expand ⟱
Source:
Type:
PAK1 (p21-activated kinase 1) is a serine/threonine kinase that plays a significant role in various cellular processes, including cell motility, proliferation, and survival.
PAK1 is often found to be overexpressed in several types of cancers, including breast cancer, prostate cancer, colorectal cancer, and pancreatic cancer.
PAK1 expression can be regulated by various oncogenic signaling pathways, including those involving RAS, PI3K/Akt, and MAPK. These pathways can lead to the activation of PAK1, further promoting cancer cell survival and proliferation.
In many cancer types, PAK1 expression and/or activity is frequently upregulated.
Overexpression and/or hyperactivation of PAK1 has been reported in breast, ovarian, colorectal, lung, and other cancers.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
6342- DRE,    Mechanistic Study on the Inhibitory Effect of Dandelion Extract on Breast Cancer Cell Proliferation and Its Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
eff↑, selectivity↑, Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, JAK1↓, STAT↓, PPARγ↑, TumCP↓, SIRT6↓, SCD1↓, STAT3↓, Casp8↓, STAT6↓, PAK1↓, FABP4↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

FABP4↓, 1,   PPARγ↑, 1,   SCD1↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Casp8↓, 1,  

DNA Damage & Repair ⓘ

SIRT6↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 1,   STAT↓, 1,   STAT3↓, 1,   STAT6↓, 1,  

Migration ⓘ

PAK1↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

JAK1↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   selectivity↑, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PAK1, 
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:240  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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