E2Fs Cancer Research Results

E2Fs, E2F family of transcription factors: Click to Expand ⟱
Source: HalifaxProj(inactivate)
Type:
E2Fs have been classified as transcriptional activators (E2F1-3) or transcriptional repressors (E2F4-8), and are thus predicted to play a dual role in human cancers.
Activators: E2F1,2,3a,3b
Repressors: E2F4,5,6,7a,7b,8
As a tumor suppressor and oncogene, the transcription factor E2F1 is a downstream regulator of the Rb pathway.
The role of E2Fs in CSCs is widely regarded as an activator gene. Up-regulation of E2Fs is reported to be involved in proliferation promotion (21), maintenance and acquisition of self-renewal (22, 23), invasion and metastatic progression (24) and resistance to chemotherapy and radiotherapy (25) in many CSCs.
BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
6340- Eug,    Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulation
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
tumCV↓, E2Fs↓, survivin↓, NF-kB↓, cycD1/CCND1↓, P21↑, TumCP↓, Apoptosis↑, TumCI↓, angioG↓,
6331- Eug,    Eugenol-Induced Autophagy and Apoptosis in Breast Cancer Cells via PI3K/AKT/FOXO3a Pathway Inhibition
- in-vitro, BC, MDA-MB-231
Apoptosis↑, TumAuto↑, TumCP↓, Akt↑, FOXO3↑, P21↑, p27↑, Casp3↑, Casp9↑, LC3s↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, E2Fs↓, survivin↓, BAX↑, Cyt‑c↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Akt↑, 1,   Apoptosis↑, 2,   BAX↑, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   p27↑, 1,   survivin↓, 2,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes ⓘ

LC3s↑, 1,   TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   E2Fs↓, 2,   P21↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

FOXO3↑, 1,  

Migration ⓘ

MMP2↓, 1,   MMP9↓, 1,   TumCI↓, 2,   TumCP↓, 2,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: E2Fs, E2F family of transcription factors
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:90  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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