MOMP Cancer Research Results

MOMP, Mitochondrial Outer Membrane Permeabilization: Click to Expand ⟱
Source:
Type:
MOMP is the point-of-no-return decision step of intrinsic apoptosis. It is the event in which the mitochondrial outer membrane becomes permeable, allowing release of pro-death factors that irreversibly commit a cell to die. Cancer progression is characterized by systematic suppression, buffering, or decoupling of MOMP from lethal execution.

MOMP occurs when BAX and/or BAK oligomerize in the mitochondrial outer membrane, forming pores that release:
-Cytochrome c → apoptosome → caspase-9
-Smac/DIABLO → IAP neutralization
-Other apoptogenic factors (e.g., Omi/HtrA2)
Once sufficient mitochondria undergo MOMP, cell death is inevitable (even if caspases are later inhibited).
Redox, Metabolism, and MOMP (Critical)
-High xCT / GSH → suppress mitochondrial ROS → MOMP ↓
-Autophagic flux → removes damaged mitochondria → MOMP ↓
-Pro-oxidant overload → mitochondrial dysfunction → MOMP ↑


BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
6367- DRE,    Antioxidant and antimicrobial activities of Dandelion root extract (Taraxacum officinale) and its cytotoxic effect on MDA-MB-231 breast cancer cells
- in-vitro, BC, MDA-MB-231
TumCD↑, *antiOx↑, *ROS↓, tumCV↓, Apoptosis↑, ROS↑, TumCCA↑, MOMP↑, ROS↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 2,  

Cell Death ⓘ

Apoptosis↑, 1,   MOMP↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ROS↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: MOMP, Mitochondrial Outer Membrane Permeabilization
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:1434  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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