miR-195 Cancer Research Results

miR-195, miR-195: Click to Expand ⟱
Source:
Type:

miR-195 is commonly downregulated and acts as a tumour suppressor. Reduced miR-195 can release inhibition of cell-cycle, survival, angiogenesis, EMT, and drug-resistance genes.

MicroRNA-195 (miR-195; commonly miR-195-5p) is a small non-coding RNA belonging to the miR-15/16/195/424/497 family. It regulates gene expression by binding target messenger RNAs and promoting transcript degradation or translational repression. In many cancers, miR-195 ↓ is the more commonly reported pattern, and miR-195 generally functions as a tumour-suppressive microRNA. Restoration or miR-195 ↑ can inhibit cell-cycle progression, proliferation, migration, invasion, angiogenesis, epithelial-mesenchymal transition, and treatment resistance while promoting apoptosis in susceptible cancer models. Reported targets include CCND1, CCNE1, CDK4, CDK6, E2F3, BCL2, BCL2L2, BIRC5, VEGF, and FGF2/bFGF. Cancer review; Recent clinical review.



BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
6985- Form,    Formononetin relieves the facilitating effect of lncRNA AFAP1-AS1-miR-195/miR-545 axis on progression and chemo-resistance of triple-negative breast cancer
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
CDK4↓, Raf↓, miR-195↑, miR-545↑, ChemoSen↑, AFAP1-AS1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AFAP1-AS1↓, 1,   miR-195↑, 1,   miR-545↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Raf↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-195, miR-195
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:1554  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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