Bax:Bcl2 Cancer Research Results

Bax:Bcl2, Bax:Bcl2 ratio: Click to Expand ⟱

Source:

Type:

Bax and Bcl-2 are the major members of Bcl-2 family that play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction.
Bax/Bcl-2 ratio is typically significantly lower in tumors.

BC, Breast Cancer: Click to Expand ⟱

Breast Cancer

Scientific Papers found: Click to Expand⟱

377-

AgNPs,

Anticancer Action of Silver Nanoparticles in SKBR3 Breast Cancer Cells through Promotion of Oxidative Stress and Apoptosis

in-vitro,

BC,

SkBr3

ROS↑, Apoptosis↑, Bax:Bcl2↑, VEGF↑, Akt↓, PI3K↓, TAC↓, TOS↑, OSI↑, MDA↑, Casp3↑, Casp7↑,

261-

ALA,

The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells

in-vitro,

BC,

MCF7

 0-2.5mM

ROS↓, Akt↓, p27/CDKN1B↑, Bax:Bcl2↑,

1078-

And,

Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway

in-vitro,

BC,

MDA-MB-231

5, 10, 25 and 50 μM

20uM

in-vitro,

Nor,

HUVECs

50uM

in-vivo,

BC,

MCF7

35uM

xenografts nude mice

in-vitro,

BC,

T47D

32uM

in-vitro,

BC,

BT549

23uM

in-vitro,

BC,

MDA-MB-361

31uM

TumCP↓, COX2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,

1367-

Ash,

An anti-cancerous protein fraction from Withania somnifera induces ROS-dependent mitochondria-mediated apoptosis in human MDA-MB-231 breast cancer cells

in-vitro,

BC,

MDA-MB-231

92 μg/mL

Apoptosis↑, ROS↑, Bax:Bcl2↑, MMP↓, Casp3↑, TumCCA↑,

1053-

Ba,

docx,

Baicalin, a Potent Inhibitor of NF-κB Signaling Pathway, Enhances Chemosensitivity of Breast Cancer Cells to Docetaxel and Inhibits Tumor Growth and Metastasis Both In Vitro and In Vivo

in-vivo,

BC,

4T1

mouse

TumCP↓, Apoptosis↑, ROS↑, Bax:Bcl2↑, NF-kB↓, ChemoSen↑, survivin↓,

5897-

CAR,

Carvacrol Selectively Induces Mitochondria-Related Apoptotic Signaling in Primary Breast Cancer-Associated Fibroblasts

in-vitro,

BC,

Bax:Bcl2↑, PPARα↓, NF-kB↓, SIRT1↑, SIRT3↑, MMP3↓, selectivity↑, Bcl-2↓, BAX↑, Casp3↑, Casp6↑, Casp9↑, mt-Apoptosis↑,

5895-

CAR,

Carvacrol as a Therapeutic Candidate in Breast Cancer: Insights into Subtype-Specific Cellular Modulation

in-vitro,

BC,

MCF7

in-vitro,

BC,

MDA-MB-231

TumCG↓, TumCMig↓, Apoptosis↑, Bax:Bcl2↑, ROS↓, CD44↓, CSCs↓,

6654-

CGA,

Chlorogenic acid induces 4T1 breast cancer tumor's apoptosis via p53, Bax, Bcl-2, and caspase-3 signaling pathways in BALB/c mice

in-vivo,

BC,

4T1

BALB/c mice

TumW↓, TumVol↓, TumMeta↓, Bax:Bcl2↑, P53↑, Casp3↑,

4772-

CoQ10,

The anti-tumor activities of coenzyme Q0 through ROS-mediated autophagic cell death in human triple-negative breast cells

in-vitro,

BC,

MDA-MB-468

 IC50 values of 4.8, 7.6, and 20.6 µM

in-vitro,

BC,

MDA-MB-231

TumCP↓, Apoptosis↑, Casp3↑, cl‑PARP↑, LC3II↑, eff↓, TumCG↓, Bax:Bcl2↑, Beclin-1↑, TumAuto↑, ROS↑,

7410-

CS,

Artichoke polyphenols induce apoptosis and decrease the invasive potential of the human breast cancer cell line MDA-MB231

in-vitro,

BC,

MDA-MB-231

selectivity↑, other↝, Apoptosis↑, DR4↑, Casp9↑, Casp8↑, Bax:Bcl2↑, P21↑, MMP↓, TumCI↓, MMP2↓,

6328-

DRE,

Hydroalcoholic extract of Taraxacum officinale induces apoptosis and autophagy in 4T1 breast cancer cells

in-vitro,

BC,

4T1

330.21, 262.38 and 145.90 µg mL-1 for 24, 48 and 72 hr, respectively.

TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, DNAdam↑, BAX↑, Bax:Bcl2↑, P53↑, Beclin-1↑, ATG7↑, Bcl-2↓, NO↓,

6963-

Form,

Formononetin-induced apoptosis by activation of Ras/p38 mitogen-activated protein kinase in estrogen receptor-positive human breast cancer cells

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MCF7

in-vitro,

BC,

T47D

eff↝, TumCP↓, TumCP∅, MAPK↑, Bax:Bcl2↑, Apoptosis↑,

2913-

LT,

Luteolin induces apoptosis by impairing mitochondrial function and targeting the intrinsic apoptosis pathway in gastric cancer cells

in-vitro,

GC,

HGC27

0, 10, 20, 30, 40, 50, 60, 70, and 80 µM) for 24 h or 48 h

in-vitro,

BC,

MCF7

in-vitro,

GC,

MKN45

TumCP↓, MMP↓, Apoptosis↑, ROS↑, SOD↓, ATP↓, Bax:Bcl2↑, TumCCA↑,

2112-

TQ,

Crude flavonoid extract of the medicinal herb Nigella sativa inhibits proliferation and induces apoptosis in breastcancer cells

in-vitro,

BC,

MCF7

45 mg/ml@72hr

Apoptosis↑, DNAdam↑, ROS↑, GSH↓, MMP↓, Casp3↑, Casp7↑, Casp9↑, Bax:Bcl2↑, P53↑, P21↑, cycD1/CCND1↓, GSSG↑, GSH/GSSG↓,

2129-

TQ,

doxoR,

Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells

in-vitro,

BC,

MCF7

25, 50 or 100 µM TQ

ChemoSen↑, PTEN↑, p‑Akt↓, TumCCA↑, P53↑, P21↑, Apoptosis↑, MMP↓, Casp↑, cl‑PARP↑, Bax:Bcl2↑, eff↓, DNAdam↓, p‑γH2AX↑, ROS↑,

1313-

VitD3,

MEL,

The effects of melatonin and vitamin D3 on the gene expression of BCl-2 and BAX in MCF-7 breast cancer cell line

in-vitro,

BC,

MCF7

 optimum dose of melatonin (5 nM) and vitamin D3 (0.5 nM

BAX↑, Bcl-2↓, Bax:Bcl2↑, eff↑,

Showing Research Papers: 1 to 16 of 16

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 16

Pathway results for Effect on Cancer / Diseased Cells:

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1, TumW↓, 1,
Total Targets: 74

Pathway results for Effect on Normal Cells:

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,
Total Targets: 2

Scientific Paper Hit Count for: Bax:Bcl2, Bax:Bcl2 ratio

2 Carvacrol
2 Thymoquinone
1 Silver-NanoParticles
1 Alpha-Lipoic-Acid
1 Andrographis
1 Ashwagandha(Withaferin A)
1 Baicalein
1 Docetaxel
1 Chlorogenic acid
1 Coenzyme Q10
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Dandelion Root
1 Formononetin
1 Luteolin
1 doxorubicin
1 Vitamin D3
1 Melatonin

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:352  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

Bax:Bcl2 Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Functional Outcomes(tgid=23) ⓘ

Pathway results for Effect on Normal Cells:

Angiogenesis & Vasculature(tgid=14) ⓘ

Functional Outcomes(tgid=23) ⓘ

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