Akt Cancer Research Results

Akt, PKB-Protein kinase B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes; Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport.

Inhibitors:
-Curcumin: downregulate AKT phosphorylation and signaling.
-Resveratrol
-Quercetin: inhibit the PI3K/AKT pathway.
-Epigallocatechin Gallate (EGCG)
-Luteolin and Apigenin: inhibit AKT phosphorylation


BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
1860- dietFMD,  Chemo,    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
- in-vitro, BC, SUM159 - in-vitro, BC, 4T1
PI3K↑, Akt↑, mTOR↑, CDK4↑, CDK6↑, hyperG↓, TumCG↓, TumVol↓, Casp3↑, BG↓, eff↑, eff∅, PKA↓, KLF5↓, p‑GSK‐3β↑, Nanog↓, OCT4↓, KLF2↓, eff↑, ROS↑, BIM↑, ASK1↑, PI3K↑, Akt↑, mTOR↑, CDK1↓, CDK4↑, CDK6↑, eff↑,
6331- Eug,    Eugenol-Induced Autophagy and Apoptosis in Breast Cancer Cells via PI3K/AKT/FOXO3a Pathway Inhibition
- in-vitro, BC, MDA-MB-231
Apoptosis↑, TumAuto↑, TumCP↓, Akt↑, FOXO3↑, P21↑, p27/CDKN1B↑, Casp3↑, Casp9↑, LC3s↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, E2Fs↓, survivin↓, BAX↑, Cyt‑c↑,
2826- FIS,    Fisetin induces apoptosis in breast cancer MDA-MB-453 cells through degradation of HER2/neu and via the PI3K/Akt pathway
- in-vitro, BC, MDA-MB-453
Apoptosis↑, p‑ENO1↓, DNAdam↑, PI3K↑, p‑Akt↑, HER2/EBBR2↓,
6977- Form,    Differential ability of formononetin to stimulate proliferation of endothelial cells and breast cancer cells via a feedback loop involving MicroRNA-375, RASD1, and ERα
- in-vitro, BC, MCF7 - in-vitro, BC, BT474 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs
*Apoptosis↓, miR-375↝, p‑Akt↑, Bcl-2↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-375↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

hyperG↓, 1,   ROS↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

KLF5↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑ENO1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 3,   p‑Akt↑, 2,   Apoptosis↑, 2,   ASK1↑, 1,   BAX↑, 1,   Bcl-2↑, 1,   BIM↑, 1,   Casp3↑, 2,   Casp9↑, 1,   Cyt‑c↑, 1,   p27/CDKN1B↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3s↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK4↑, 2,   E2Fs↓, 1,   P21↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXO3↑, 1,   p‑GSK‐3β↑, 1,   mTOR↑, 2,   Nanog↓, 1,   OCT4↓, 1,   PI3K↑, 3,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

KLF2↓, 1,   MMP2↓, 1,   MMP9↓, 1,   PKA↓, 1,   TumCI↓, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 3,   eff∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 1,   HER2/EBBR2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,  
Total Targets: 45

Pathway results for Effect on Normal Cells:


Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: Akt, PKB-Protein kinase B
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Eugenol
1 Fisetin
1 Formononetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:4  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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