LTA/TNF-β Cancer Research Results

LTA/TNF-β, LTA / TNF-β / lymphotoxin-α: Click to Expand ⟱
Source:
Type:
Tumor Necrosis Factor-beta (TNF-β), also known as Lymphotoxin-alpha (LT-α), is a cytokine involved in systemic inflammation and one of the cytokines that make up the tumor necrosis factor family.
TNF-β is typically high expression in cancers with poor prognosis.
Field Suggested Entry
Target LTA / lymphotoxin-α / TNF-β
Full Name Lymphotoxin alpha
Target Class TNF-superfamily cytokine
Main Receptors TNFR1/TNFRSF1A, TNFR2/TNFRSF1B, HVEM/TNFRSF14; LTBR/TNFRSF3 when complexed with LTB
Primary Biology Lymphocyte-derived inflammatory signaling, immune activation, antiviral response, apoptosis signaling, lymphoid tissue organization, secondary lymphoid organ development
Cancer Relevance Medium and context-dependent: may contribute to tumor-cell cytotoxicity, cancer immunity, lymphoid-structure formation, chronic inflammation, and tumor microenvironment remodeling depending on context
AD Relevance Low-medium: indirect relevance through TNF-family neuroinflammation; less established than TNF-α, TNFR1, or TNFR2
Therapeutic Direction Context-dependent. Suppress excessive/pathological inflammatory signaling where appropriate, but avoid assuming that LTA inhibition is always beneficial because lymphotoxin signaling can also support immune defense and tumor surveillance.


BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
6594- Anamu,    Dibenzyl trisulfide induces caspase-independent death and lysosomal membrane permeabilization of triple-negative breast cancer cells
- in-vitro, BC, HCC1806/CRL-2335 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
TumCP↓, TumCMig↓, Bak↑, GADD45A↑, LTA/TNF-β↑, lysoMP↑, P450↓, cl‑PARP↑, Dose↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Bak↑, 1,   lysoMP↑, 1,  

DNA Damage & Repair ⓘ

GADD45A↑, 1,   cl‑PARP↑, 1,  

Migration ⓘ

TumCMig↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

LTA/TNF-β↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   P450↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LTA/TNF-β, LTA / TNF-β / lymphotoxin-α
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:914  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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