Cancer Database Query Results

BC, Breast Cancer: Click to Expand ⟱
Breast Cancer
Scientific Papers found: Click to Expand⟱
5282- 3BP,  Rad,    3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
Glycolysis↓, RadioS↑, eff↑, GAPDH↓, PPP↑, GSH↓, ECAR↓,
5261- 3BP,    The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH
- in-vitro, BC, NA
eff↑, eff↓,
5461- AF,    Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
Paraptosis↑, ER Stress↑, TrxR↓, selectivity↑, toxicity↝, ROS↑, mt-TrxR1↓, mt-TrxR2↓,
1333- AG,    Astragalus polysaccharide inhibits breast cancer cell migration and invasion by regulating epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway
- in-vitro, BC, NA
TumCMig↓, TumCI↓, Ki-67↓, TumCP↓, Snail↓, Vim↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓,
1335- AG,    Extract from Astragalus membranaceus inhibit breast cancer cells proliferation via PI3K/AKT/mTOR signaling pathway
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
p‑PI3K↓, p‑GS3Kβ↓, p‑Akt↓, p‑mTOR↓,
1338- AG,    The Modulatory Properties of Astragalus membranaceus Treatment on Triple-Negative Breast Cancer: An Integrated Pharmacological Method
- in-vitro, BC, NA
TumCI↓, Apoptosis↑, Symptoms↓, PIK3CA↓, Akt↓, Bcl-2↓,
1000- AG,  5-FU,    Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation
- vitro+vivo, BC, 4T1
TumCG↓, TumCCA↑, Apoptosis↑, *IL2↑, *TNF-α↑, *IFN-γ↑,
5429- AG,    Astragalus polysaccharides improve adjuvant chemotherapy-induced fatigue for patients with early breast cancer
- Human, BC, NA
chemoP↑, other↝,
1907- AgNPs,  GoldNP,  Cu,    In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands
- in-vitro, Lung, A549 - in-vitro, BC, MCF7 - in-vitro, Melanoma, A375 - in-vitro, Colon, HCT15 - in-vitro, Cerv, HeLa
TrxR↓, eff↓, eff↓, other∅,
1594- AgNPs,  Citrate,    Silver Citrate Nanoparticles Inhibit PMA-Induced TNFα Expression via Deactivation of NF-κB Activity in Human Cancer Cell-Lines, MCF-7
- in-vitro, BC, MCF7
TNF-α↓, NF-kB↓, antiOx↑, TumCP↓,
4402- AgNPs,    Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors
- in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCD↑, selectivity↑, *toxicity↝, Dose↝, OS↑,
4401- AgNPs,  Rad,    Metformin-loaded chitosan nanoparticles augment silver nanoparticle-induced radiosensitization in breast cancer cells during radiation therapy
- in-vitro, BC, NA
RadioS↑, DNAdam↑,
4400- AgNPs,  Rad,    Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, BC, MDA-MB-231
ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, eff↑,
4417- AgNPs,    Caffeine-boosted silver nanoparticles target breast cancer cells by triggering oxidative stress, inflammation, and apoptotic pathways
- in-vitro, BC, MDA-MB-231
ROS↑, MDA↑, COX2/PTGS2↑, IL1β↑, TNF-α↑, GSH↓, Cyt‑c↑, Casp3↑, BAX↑, Bcl-2↓, LDH↓, cycD1/CCND1↓, CDK2↓, TumCCA↑, mt-Apoptosis↑,
4416- AgNPs,    Efficacy of curcumin-synthesized silver nanoparticles on MCF-7 breast cancer cells
- in-vitro, BC, MCF7
TumCMig↓, Apoptosis↑, BAX↑, P53↑, Bcl-2↓,
4415- AgNPs,  SDT,  CUR,    Examining the Impact of Sonodynamic Therapy With Ultrasound Wave in the Presence of Curcumin-Coated Silver Nanoparticles on the Apoptosis of MCF7 Breast Cancer Cells
- in-vitro, BC, MCF7
tumCV↓, BAX↑, Casp3↑, Bcl-2↓, eff↑, ROS↑, sonoS↑, eff↑, MMP↓, Cyt‑c↑,
4413- AgNPs,  Anzaroot,    Green synthesis of silver nanoparticles from plant Astragalus fasciculifolius Bioss and evaluating cytotoxic effects on MCF7 human breast cancer cells
- in-vitro, BC, MCF7
chemoP↑, TumCG↓, eff↑, CellMemb↑, selectivity↑, ROS↑, P53↑,
4409- AgNPs,    Plant-based synthesis of gold and silver nanoparticles using Artocarpus heterophyllus aqueous leaf extract and its anticancer activities
- in-vitro, BC, MCF7
tumCV↓, TumCCA↑, cycD1/CCND1↓, COX2/PTGS2↓, HER2/EBBR2↓,
4408- AgNPs,    Chitosan-coated silver nanoparticles synthesized using Moringa oleifera flower extract: A potential therapeutic approach against triple-negative breast cancer
- in-vitro, BC, MDA-MB-231
tumCV↓,
4407- AgNPs,    Green Synthesis and Characterization of Silver Nanoparticles from Eclipta alba and Its Activity Against Triple-Negative Breast Cancer Cell Line (MDA-MB-231)
- in-vitro, BC, MDA-MB-231
antiOx↑, TumCG↓,
4406- AgNPs,    Silver nanoparticles achieve cytotoxicity against breast cancer by regulating long-chain noncoding RNA XLOC_006390-mediated pathway
- in-vitro, BC, MCF7 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
TumCD↑, other↓, P53↑, TumCCA↑, Apoptosis↑, ChemoSen↑, tumCV↓, γH2AX↑, SOX4↓,
4431- AgNPs,  doxoR,    Oxidative Stress-Induced Silver Nano-Carriers for Chemotherapy
- in-vitro, BC, 4T1 - in-vivo, BC, 4T1 - in-vitro, Nor, 3T3
AntiCan↑, ROS↑, TumVol↓, EPR↑, selectivity↑, ChemoSen↑,
4364- AgNPs,    Selective cytotoxicity of green synthesized silver nanoparticles against the MCF-7 tumor cell line and their enhanced antioxidant and antimicrobial properties
- in-vitro, BC, MCF7
TumCD↑, selectivity↑, *antiOx↑, *Inflam↓, AntiTum↑, ROS↑,
4374- AgNPs,    Enhancing antitumor activity of silver nanoparticles by modification with cell-penetrating peptides
- in-vitro, BC, MCF7
eff↑, TumCD↑,
4563- AgNPs,  Rad,    Silver nanoparticles enhance neutron radiation sensitivity in cancer cells: An in vitro study
- in-vitro, BC, MCF7 - in-vitro, Ovarian, SKOV3 - in-vitro, GBM, U87MG - in-vitro, Melanoma, A431
RadioS↑, ROS↑, TumCCA↑, Apoptosis↑, ER Stress↑,
4559- AgNPs,    Anticancer activity of biogenerated silver nanoparticles: an integrated proteomic investigation
- in-vitro, BC, SkBr3 - in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116 - in-vitro, Colon, Caco-2
MMP2↓, MMP9↓, ROS↑, TumAuto↑, Apoptosis↑, ER Stress↑,
4548- AgNPs,  Chit,    Synergistic combination of antioxidants, silver nanoparticles and chitosan in a nanoparticle based formulation: Characterization and cytotoxic effect on MCF-7 breast cancer cell lines
- in-vitro, BC, MCF7
AntiCan↑, EPR↑, pH↝,
4541- AgNPs,  RosA,    Eco-friendly synthesis of silver nanoparticles: multifaceted antioxidant, antidiabetic, anticancer, and antimicrobial activities
- in-vitro, Nor, WI38 - in-vitro, BC, MDA-MB-231 - in-vitro, PC, PANC1
*antiOx↑, TumCD↓, selectivity↑,
4593- AgNPs,  Chit,    Chitosan-coated silver nanoparticles promoted antibacterial, antibiofilm, wound-healing of murine macrophages and antiproliferation of human breast cancer MCF 7 cells
- in-vitro, BC, MCF7
*Bacteria↓, *Wound Healing↑, TumCG↓,
5145- AgNPs,    Silver nanoparticles induce irremediable endoplasmic reticulum stress leading to unfolded protein response dependent apoptosis in breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, T47D
Bacteria↓, Apoptosis↑, ER Stress↑, UPR↑, PERK↑, IRE1↑, ATF6↑, ATF4↑, CHOP/DDIT3↑, Casp9↑, Casp7↑, Mcl-1↓, XIAP↓, PARP↝, selectivity↑,
339- AgNPs,    Cancer cell specific cytotoxic potential of the silver nanoparticles synthesized using the endophytic fungus, Penicillium citrinum CGJ-C2
- in-vitro, BC, MCF7 - in-vitro, Melanoma, A431 - in-vitro, HCC, HepG2
TumCD↑,
336- AgNPs,  PDT,    Photodynamic ability of silver nanoparticles in inducing cytotoxic effects in breast and lung cancer cell lines
- in-vitro, BC, MCF7
Apoptosis↑,
316- AgNPs,    Endoplasmic reticulum stress: major player in size-dependent inhibition of P-glycoprotein by silver nanoparticles in multidrug-resistant breast cancer cells
- in-vitro, BC, MCF7
GRP78/BiP↑, ER Stress↑, ROS↑, mtDam↑,
374- AgNPs,    Silver nanoparticles selectively treat triple‐negative breast cancer cells without affecting non‐malignant breast epithelial cells in vitro and in vivo
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
ER Stress↑, DNAdam↑, ROS↑, Apoptosis↑, GSH/GSSG↓, NADPH/NADP+↓, TumCG↓, UPR↑,
366- AgNPs,    Silver nanoparticles inhibit the function of hypoxia-inducible factor-1 and target genes: insight into the cytotoxicity and antiangiogenesis
- in-vitro, BC, MCF7
HIF-1↓, Hif1a↓, VEGF↓, GLUT1↓,
348- AgNPs,    Induction of p53 mediated mitochondrial apoptosis and cell cycle arrest in human breast cancer cells by plant mediated synthesis of silver nanoparticles from Bergenia ligulata (Whole plant)
- in-vitro, BC, MCF7
Apoptosis↑, ROS↑, MMP↓, P53↑, BAX↑, cl‑Casp3↑,
349- AgNPs,    Insight into the molecular mechanism, cytotoxic, and anticancer activities of phyto-reduced silver nanoparticles in MCF-7 breast cancer cell lines
- in-vitro, BC, MCF7
Apoptosis↑, ROS↑, CellMemb↑,
350- AgNPs,    Cytotoxic and Apoptotic Effects of Green Synthesized Silver Nanoparticles via Reactive Oxygen Species-Mediated Mitochondrial Pathway in Human Breast Cancer Cells
- in-vitro, BC, MCF7
ROS↑, MMP↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓,
351- AgNPs,    Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
- in-vitro, BC, MCF7 - in-vitro, BC, T47D
Casp9↑, Casp3↑, Casp7↑, Bcl-2↓,
352- AgNPs,    Synthesis of silver nanoparticles (Ag NPs) for anticancer activities (MCF 7 breast and A549 lung cell lines) of the crude extract of Syzygium aromaticum
- in-vitro, BC, MCF7
TumCD↑,
356- AgNPs,  MF,    Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro study
- in-vitro, BC, MCF7 - in-vitro, Bladder, HTB-22
Apoptosis↑, P53↑, iNOS↑, NF-kB↑, Bcl-2↓, ROS↑, SOD↑, TumCCA↑, eff↑, Catalase↑, other↑,
360- AgNPs,  Moringa,    Cytotoxic and Genotoxic Evaluation of Biosynthesized Silver Nanoparticles Using Moringa oleifera on MCF-7 and HUVEC Cell Lines
- in-vitro, BC, MCF7 - in-vitro, BC, HUVECs
DNAdam↑,
353- AgNPs,    The mechanism of cell death induced by silver nanoparticles is distinct from silver cations
- in-vitro, BC, SUM159
lipid-P↑, H2O2↑, ROS↑, Apoptosis↑,
377- AgNPs,    Anticancer Action of Silver Nanoparticles in SKBR3 Breast Cancer Cells through Promotion of Oxidative Stress and Apoptosis
- in-vitro, BC, SkBr3
ROS↑, Apoptosis↑, Bax:Bcl2↑, VEGF↑, Akt↓, PI3K↓, TAC↓, TOS↑, OSI↑, MDA↑, Casp3↑, Casp7↑,
402- AgNPs,  MF,    Anticancer and antibacterial potentials induced post short-term exposure to electromagnetic field and silver nanoparticles and related pathological and genetic alterations: in vitro study
- in-vitro, BC, MCF7
P53↑, iNOS↑, NF-kB↑, Bcl-2↓, miR-125b↓, ROS↑, SOD↑,
376- AgNPs,    Antitumor activity of colloidal silver on MCF-7 human breast cancer cells
- in-vitro, BC, MCF7
Apoptosis↑, LDH↓, SOD↑, DNAdam↑,
389- AgNPs,  Citrate,    Silver Citrate Nanoparticles Inhibit PMA-Induced TNFα Expression via Deactivation of NF-κB Activity in Human Cancer Cell-Lines, MCF-7
- in-vitro, BC, MCF7
TNF-α↓, NF-kB↓,
378- AgNPs,    Antitumor efficacy of silver nanoparticles reduced with β-D-glucose as neoadjuvant therapy to prevent tumor relapse in a mouse model of breast cancer
- ex-vivo, BC, 4T1
TumVol↓, TumMeta↓, Ki-67↓,
382- AgNPs,    Investigation the apoptotic effect of silver nanoparticles (Ag-NPs) on MDA-MB 231 breast cancer epithelial cells via signaling pathways
- in-vitro, BC, MDA-MB-231
Apoptosis↑, BAX↑, Bcl-2↓, P53↑, PTEN↑, hTERT/TERT↓, p‑ERK↓, cycD1/CCND1↓,
386- AgNPs,  Tam,    Synergistic anticancer effects and reduced genotoxicity of silver nanoparticles and tamoxifen in breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
P53↑, BAX↑, Bcl-2↓, Casp3↑, DNAdam↑, TumCCA↑,

Showing Research Papers: 1 to 50 of 807
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 807

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

2/16-OHE1↑, 2,   6IL↑, 3,   8-oxo-dG↓, 1,   AApath↓, 1,   AFAP1-AS1↓, 1,   AKT3↓, 1,   ALDH1A3↓, 1,   p‑AMT/GCST/T-protein↑, 1,   ANAPC2↑, 1,   APOE4↑, 1,   AURKB↑, 1,   CASP4↑, 1,   CD155↓, 1,   circNAV3↓, 1,   compII↓, 1,   CR↑, 2,   DHODH↓, 1,   DR6↑, 1,   EDEM↑, 1,   EFS↑, 1,   ENL↑, 1,   FEN1↓, 2,   GALNT10↓, 1,   HES1↓, 1,   HSP60/HSPD1↑, 1,   IL13↓, 1,   Ingr?, 1,   IP6K1↓, 1,   ITGA6↓, 1,   KAI1/CD82↑, 1,   Ku70/XRCC6↓, 1,   LATS1↓, 1,   LC↑, 1,   miR-122-5p↑, 1,   miR-134↑, 1,   miR-195↑, 1,   miR-199↓, 1,   miR-375↝, 1,   miR-542↓, 1,   miR-545↑, 1,   NA↓, 1,   NA↑, 1,   Nausea↓, 1,   Nausea∅, 1,   PA↑, 1,   PRKCQ/PKCθ↓, 1,   PRMT6↓, 1,   PXR, NR1I2↓, 1,   RBC↑, 2,   SGK1↓, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TTP↑, 1,   UGDH↓, 2,   Vomit↓, 1,   Vomit∅, 1,   WBC↑, 1,   XRCC1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 12,   ATF3↑, 1,   Catalase↓, 3,   Catalase↑, 5,   compI↓, 1,   Copper↓, 1,   ENOX2↓, 1,   Fenton↑, 5,   Ferroptosis↑, 12,   GCLM↑, 2,   GPx↓, 1,   GPx↑, 1,   GPx1⇅, 1,   GPx4↓, 8,   GSH↓, 30,   GSH↑, 3,   GSH/GSSG↓, 5,   GSSG↓, 1,   GSSG↑, 5,   GSTA1↓, 1,   GSTP1/GSTπ↓, 1,   GSTP1/GSTπ↝, 1,   H2O2↓, 2,   H2O2↑, 6,   e-H2O2↓, 1,   i-H2O2∅, 1,   HO-1↓, 6,   HO-1↑, 6,   hyperG↓, 1,   ICD↑, 2,   Iron↓, 2,   Iron↑, 7,   i-Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 2,   lipid-P↑, 10,   MDA↓, 1,   MDA↑, 7,   i-MDA↑, 1,   NADH↑, 1,   mt-NADH↑, 1,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NQO1↑, 3,   Nrf1↓, 1,   Nrf1↑, 1,   NRF2↓, 7,   NRF2↑, 16,   NRF2⇅, 1,   NRF2↝, 1,   NRF2∅, 1,   p‑NRF2↑, 1,   OSI↑, 1,   OXPHOS↓, 6,   OXPHOS↑, 2,   OXPHOS∅, 1,   PAO↑, 1,   PrxII↓, 1,   ROS?, 1,   ROS↓, 22,   ROS↑, 192,   ROS⇅, 1,   ROS↝, 2,   ROS∅, 4,   i-ROS?, 1,   mt-ROS↑, 4,   SIRT3↑, 2,   SOD↓, 3,   SOD↑, 6,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,   mt-SOD2↑, 1,   TAC↓, 1,   Thiols↓, 2,   TOS↑, 1,   Trx↓, 1,   Trx1↓, 2,   TrxR↓, 4,   TrxR1?, 1,   mt-TrxR1↓, 1,   mt-TrxR2↓, 1,   xCT/SLC7A11↓, 5,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   FTH1↑, 1,   FTL↑, 1,   KLF5↓, 1,   Tf↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 4,   AIF↝, 1,   ATP↓, 29,   ATP↑, 1,   ATP⇅, 1,   ATP↝, 1,   ATP∅, 1,   CDC25↓, 2,   CDC25↑, 1,   compIII↑, 1,   ETC↓, 1,   FIS1↓, 1,   MEK↓, 1,   p‑MEK↓, 2,   mitResp↓, 4,   mitResp↑, 1,   MMP?, 1,   MMP↓, 57,   MMP↑, 2,   MMP∅, 1,   MPT↑, 4,   mtDam↑, 13,   OCR↓, 7,   OCR↑, 2,   mt-OCR↑, 1,   p‑p42↓, 1,   PGC-1α↓, 1,   PGC-1α↑, 1,   PHB↓, 1,   Raf↓, 2,   c-Raf↓, 1,   XIAP?, 1,   XIAP↓, 6,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   ACC-α↓, 1,   ACC1↓, 1,   ACLY↓, 4,   AKT1↓, 2,   ALAT↓, 3,   ALDOA↓, 1,   AMPK↓, 1,   AMPK↑, 12,   p‑AMPK↑, 5,   ANXA7↑, 2,   ATG7↑, 1,   cAMP⇅, 1,   Cav1↓, 1,   Cav1↑, 2,   cMyc↓, 15,   CPT1A↓, 1,   CREB↓, 1,   CREB↑, 1,   CYP3A4↓, 1,   ECAR↓, 10,   p‑ENO1↓, 1,   ENO2↓, 1,   FABP4↓, 1,   FAO↓, 1,   FASN↓, 4,   FASN↑, 1,   i-FASN↓, 1,   FBI-1↓, 1,   FBPase↑, 1,   FDG↓, 2,   G6PD↓, 2,   GAPDH↓, 3,   GLO-I↓, 1,   glucose↓, 2,   glucose∅, 1,   GlucoseCon↓, 20,   GlucoseCon↑, 1,   GlutMet↓, 1,   Glycolysis↓, 37,   p‑GS3Kβ↓, 1,   HK2↓, 16,   HMG-CoA↓, 3,   IR↓, 1,   lactateProd↓, 20,   lactateProd↝, 1,   LDH↓, 9,   LDH↑, 1,   LDH∅, 1,   p‑LDH↓, 1,   e-LDH↑, 1,   LDHA↓, 14,   LDHB↓, 1,   LDL↓, 1,   lipidLev↓, 1,   MCT4↓, 1,   NAD↓, 2,   NADPH↓, 1,   PCK1↓, 1,   PDH↑, 2,   p‑PDH↓, 1,   p‑PDH↑, 1,   PDK1 / PDPK1↓, 8,   p‑PDK1 / PDPK1↓, 2,   PDKs↓, 2,   PDKs↑, 1,   PFK↓, 5,   PFKP↓, 1,   PGAM1↓, 1,   PGK1↓, 2,   PGM1↓, 1,   PI3K/Akt↓, 3,   PI3k/Akt/mTOR↓, 2,   PIK3CA↓, 1,   PKM1↑, 1,   PKM2↓, 21,   PKM2↑, 1,   POLD1↓, 1,   PPARα↓, 2,   PPARγ↓, 1,   PPARγ↑, 9,   PPP↓, 1,   PPP↑, 1,   PSMB5↓, 1,   p‑S6↓, 1,   p‑S6K↓, 1,   SCD1↓, 1,   SHARP↑, 2,   SIRT1↓, 1,   SIRT1↑, 4,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   SSAT↑, 1,   TCA↓, 2,   TCA↑, 2,   Warburg↓, 4,   Warburg↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 55,   Akt↑, 3,   p‑Akt↓, 27,   p‑Akt↑, 2,   Apoptosis?, 4,   Apoptosis↓, 7,   Apoptosis↑, 221,   Apoptosis∅, 2,   m-Apoptosis↑, 1,   mt-Apoptosis↑, 2,   ASK1↑, 1,   aSmase↑, 1,   BAD↓, 1,   BAD↑, 5,   Bak↑, 4,   BAX↓, 3,   BAX↑, 79,   BAX⇅, 1,   BAX↝, 1,   BAX∅, 1,   Bax:Bcl2↑, 19,   Bcl-2↓, 102,   Bcl-2↑, 2,   Bcl-2∅, 1,   Bcl-xL↓, 10,   Bcl-xL∅, 1,   BIM↑, 2,   BMP2↑, 1,   Casp↑, 14,   Casp↝, 1,   Casp3?, 1,   Casp3↓, 2,   Casp3↑, 74,   Casp3↝, 1,   cl‑Casp3↑, 20,   Casp6↑, 2,   Casp7↑, 10,   cl‑Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 12,   Casp8↝, 1,   cl‑Casp8↑, 6,   Casp9↑, 37,   Casp9↝, 1,   cl‑Casp9↑, 6,   cFLIP↓, 1,   Chk2↑, 1,   CK2↓, 2,   Cyt‑c↑, 26,   DR4↑, 3,   DR5↑, 4,   FADD↑, 2,   Fas↓, 1,   Fas↑, 4,   FasL↑, 1,   Ferroptosis↑, 12,   GADD34↑, 1,   GranA↓, 1,   GranB/GZMB↓, 1,   GSDMC↑, 1,   GSDMD↑, 1,   GSDME↑, 1,   hTERT/TERT↓, 5,   IAP1↓, 1,   iNOS↓, 1,   iNOS↑, 3,   JNK↓, 1,   JNK↑, 4,   p‑JNK↑, 2,   cl‑JNK↑, 1,   lysoMP↑, 1,   MAPK↓, 5,   MAPK↑, 4,   p‑MAPK↑, 1,   Mcl-1↓, 5,   Mcl-1↑, 1,   MCT1↓, 1,   MDM2↓, 1,   miR-127-5p↑, 2,   MLKL↑, 2,   MOMP↓, 1,   MOMP↑, 1,   Myc↓, 3,   Necroptosis↑, 3,   necrosis↑, 9,   p27/CDKN1B↑, 8,   p38↓, 2,   p38↑, 5,   p‑p38↓, 2,   p‑p38↑, 3,   Paraptosis↑, 4,   Perforin↓, 1,   Proteasome↓, 2,   pS2/TFF1↑, 1,   PUMA↑, 1,   Pyro↑, 3,   RIP1↓, 1,   sFasL↑, 1,   SK↓, 1,   survivin↓, 25,   survivin↝, 1,   Telomerase↓, 1,   TRAIL↑, 1,   TumCD↓, 2,   TumCD↑, 28,   TUNEL↑, 1,   YAP/TEAD↓, 5,   YAP/TEAD↑, 1,   p‑YAP/TEAD↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↑, 1,   cSrc↓, 1,   H3K18↓, 1,   HER2/EBBR2↓, 13,   PAK↓, 1,   Sp1/3/4↓, 5,   Sp1/3/4↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 3,   EZH2↓, 3,   H19↓, 1,   H3↓, 1,   p‑H3↓, 1,   ac‑H3↑, 3,   ac‑H4↑, 1,   ac‑H4∅, 1,   HATs↓, 1,   miR-145↑, 1,   miR-205↑, 1,   other?, 2,   other↓, 7,   other↑, 13,   other⇅, 2,   other↝, 17,   other∅, 2,   pRB↓, 1,   p‑pRB↓, 1,   SETBP1↓, 1,   sonoS↑, 2,   tumCV?, 1,   tumCV↓, 86,   tumCV↑, 1,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   ATFs↑, 1,   CHOP/DDIT3↑, 10,   eIF2α↑, 1,   p‑eIF2α↑, 5,   ER Stress↑, 20,   ER Stress↝, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 5,   HSP27↓, 2,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 3,   HSP70/HSPA5∅, 1,   HSP90↓, 6,   HSP90↑, 1,   IRE1↑, 1,   PERK↑, 4,   UPR↑, 3,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG5↝, 1,   autoF↓, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 3,   Beclin-1/ATG6↝, 1,   BNIP3?, 1,   BNIP3↓, 1,   BNIP3↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 2,   LC3II↑, 7,   LC3s↑, 1,   lysosome↓, 2,   p62↓, 5,   p62↑, 2,   SESN2↑, 2,   TumAuto↓, 3,   TumAuto↑, 28,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   p‑ATM↑, 1,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA1↝, 1,   BRCA2↑, 1,   CYP1B1↓, 1,   CYP1B1↑, 1,   DNA-PK↑, 1,   DNAdam↓, 2,   DNAdam↑, 40,   DNArepair↓, 1,   DNMT1↓, 6,   DNMT3A↓, 2,   DNMT3A↑, 1,   DNMT3B↓, 1,   DNMTs↓, 7,   G9a↓, 1,   GADD45A↑, 5,   p16↑, 1,   P53↓, 2,   P53↑, 43,   P53⇅, 1,   P53↝, 1,   p‑P53↑, 4,   p53 Wildtype↓, 1,   PARP↓, 3,   PARP↑, 3,   PARP↝, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 32,   cl‑PARP↝, 1,   PARP1↑, 1,   cl‑PARP1↑, 2,   PCNA↓, 5,   PCNA↝, 1,   RAD51↑, 1,   SIRT6↓, 1,   TP53↓, 2,   UHRF1↓, 2,   γH2AX↑, 7,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1?, 1,   CDK1↓, 8,   CDK2↓, 4,   p‑CDK2↓, 1,   CDK4↓, 8,   CDK4↑, 2,   CDK4↝, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 8,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 38,   CycD3↓, 1,   cycE/CCNE↓, 4,   cycF↑, 1,   E2Fs↓, 2,   mitA↑, 1,   P21↓, 3,   P21↑, 31,   PLK1↓, 3,   p‑RB1↓, 1,   TumCCA↓, 2,   TumCCA↑, 128,   TumCCA⇅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 5,   ALDH1A1↓, 2,   CD133↓, 1,   CD24↓, 7,   CD34↓, 1,   CD44↓, 13,   CD44↑, 1,   cDC2↓, 1,   cFos↓, 1,   cMET↓, 3,   CREB2↓, 1,   CSCs↓, 44,   CSCs↑, 1,   CSCsMark↓, 2,   CTNNB1↓, 1,   CTSB↓, 2,   CTSD↓, 1,   CTSL↓, 1,   CTSL↑, 1,   CTSS↓, 1,   Diff↑, 6,   EMT↓, 34,   EP300↓, 1,   EpCAM↓, 1,   ERK↓, 12,   ERK↑, 3,   p‑ERK↓, 12,   p‑ERK↑, 3,   FGF↓, 2,   FOXM1↓, 3,   FOXO↑, 2,   FOXO3↑, 1,   FOXO4↓, 1,   Gli1↓, 7,   GREM1↓, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 4,   p‑GSK‐3β↑, 1,   H3K27ac↓, 1,   HDAC↓, 15,   HDAC∅, 1,   HDAC1↓, 3,   HDAC2↓, 2,   HDAC3↓, 2,   HDAC4↓, 2,   HDAC8↓, 4,   HH↓, 7,   HMGCR↓, 2,   HMGCR⇅, 1,   HMTs↓, 1,   Id1↓, 1,   IGF-1↓, 7,   IGF-1↑, 1,   IGF-1∅, 1,   IGF-1R↓, 6,   IGF-2↓, 1,   IGFBP1↓, 1,   IGFBP3↓, 1,   IGFBP3↑, 1,   IGFR↓, 1,   KLF4↓, 1,   Let-7↓, 1,   Let-7↑, 1,   LRP6↓, 4,   p‑LRP6↓, 2,   miR-125b↓, 1,   miR-125b↝, 1,   miR-142-3p↑, 1,   miR-34a↑, 1,   miR-448↑, 1,   MSCmark↓, 2,   Mst1↑, 1,   mTOR↓, 34,   mTOR↑, 2,   mTOR⇅, 1,   mTOR∅, 1,   p‑mTOR↓, 4,   mTORC1↓, 2,   Nanog↓, 7,   Nanog↑, 1,   NOTCH↓, 1,   NOTCH1↓, 4,   OCT4↓, 7,   OCT4↑, 1,   p‑P70S6K↓, 1,   PI3K↓, 29,   PI3K↑, 3,   p‑PI3K↓, 6,   PIAS-3↑, 1,   PR↑, 1,   PTCH1↓, 2,   PTEN↓, 1,   PTEN↑, 8,   RAS↓, 3,   SAL↑, 1,   Shh↓, 2,   SHP1↑, 1,   Smo↓, 3,   SOX2↓, 6,   Src↓, 3,   STAT↓, 1,   STAT1↓, 1,   p‑STAT1↓, 1,   STAT3↓, 25,   STAT3↑, 3,   p‑STAT3↓, 14,   STAT4↓, 1,   STAT5↓, 2,   STAT6↓, 1,   TAZ↓, 1,   TCF↓, 1,   TOP1↓, 3,   TPM4↓, 1,   TRPM7↓, 2,   TumCG?, 1,   TumCG↓, 126,   TumCG↑, 3,   TumCG⇅, 1,   TumCG↝, 2,   TumCG∅, 3,   VGSC↑, 1,   Wnt↓, 15,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   Akt2↓, 1,   Alix/AIP‑1↓, 1,   AP-1↓, 2,   AP-1↝, 1,   ATPase↓, 3,   AXL↓, 1,   BACH1↑, 2,   Brk/PTK6↓, 1,   Ca+2↓, 1,   Ca+2↑, 17,   Ca+2↝, 1,   i-Ca+2↑, 2,   CCDC150↓, 1,   CD11b↓, 1,   CDH1↑, 2,   CLDN1↓, 1,   COL11A1↓, 1,   COL1A1↓, 2,   DLC1↑, 3,   E-cadherin↓, 4,   E-cadherin↑, 26,   EM↑, 2,   EphB4↓, 1,   ER-α36↓, 6,   ER-α36↝, 1,   F-actin↓, 1,   F-actin↑, 1,   FAK↓, 10,   FAK↑, 1,   Fibronectin↓, 3,   FOSB↑, 2,   Furin↓, 4,   GLI2↓, 1,   hnRNPA1↓, 1,   ITGA5↓, 2,   ITGA5↑, 2,   ITGB1↓, 2,   ITGB1↑, 2,   ITGB3↓, 1,   ITGB4↓, 1,   Ki-67↓, 15,   KLF2↓, 1,   LAMA5↑, 2,   LEF1↓, 1,   MET↑, 1,   miR-200c↑, 1,   miR-29b↓, 1,   miR-29b↑, 1,   MMP-10↓, 1,   MMP13↓, 1,   MMP2↓, 27,   MMP3↓, 3,   MMP7↓, 1,   MMP9↓, 41,   MMPs↓, 5,   MOB1↓, 1,   MUC1↓, 1,   N-cadherin↓, 6,   N-cadherin↑, 1,   NEDD9↓, 1,   NeuroT↓, 1,   p‑p44↓, 1,   PAI-1/SERPINE1↓, 1,   PAK1↓, 3,   pax↓, 1,   PDGF↓, 1,   PKA↓, 1,   PKA↑, 1,   PKCδ↓, 1,   PKCδ↑, 2,   PRNP↑, 1,   PTP1B↓, 1,   Rho↓, 2,   RIP3↑, 2,   p‑RIP3↑, 1,   ROCK1↓, 1,   Slug↓, 11,   SMAD2↓, 2,   p‑SMAD2↓, 2,   SMAD3↓, 6,   p‑SMAD3↓, 1,   Snail↓, 13,   Snail↑, 3,   SOX4↓, 1,   SOX4↑, 1,   TET1↑, 1,   TGF-β↓, 12,   TGF-β1↓, 1,   THBS1↑, 1,   TIMP1↓, 2,   TIMP1↑, 1,   TIMP2↑, 2,   Treg lymp↓, 1,   TRPC1↑, 1,   TSC1↑, 1,   TumCA↓, 2,   TumCI↓, 74,   TumCI↑, 2,   TumCMig↓, 74,   TumCMig↑, 1,   TumCP↓, 149,   TumCP↑, 4,   TumCP∅, 1,   TumMeta↓, 57,   TumMeta↑, 1,   Twist↓, 4,   Twist↑, 1,   TXNIP↓, 1,   TXNIP↑, 1,   uPA↓, 2,   uPAR↓, 1,   UroPA↓, 1,   VCAM-1↓, 2,   Vim?, 1,   Vim↓, 26,   Vim↑, 2,   Zeb1↓, 9,   Zeb1↑, 3,   ZEB2↑, 2,   ZO-1↑, 1,   α-SMA↓, 1,   α-tubulin↓, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 24,   β-catenin/ZEB1↑, 1,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 30,   ATF4↑, 3,   ECM/TCF↓, 1,   EGFR↓, 10,   EGR4↓, 1,   eNOS↑, 1,   EPR↓, 1,   EPR↑, 10,   EPR↝, 1,   HIF-1↓, 3,   Hif1a↓, 30,   Hypoxia↓, 1,   miR-126↑, 1,   miR-17↓, 1,   NO↓, 2,   NO↑, 6,   REL↑, 1,   TAMS↑, 1,   VEGF↓, 34,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 2,   VHL↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 1,   BBB↝, 1,   CellMemb↑, 5,   GLUT1↓, 13,   GLUT3↓, 1,   P-gp/ABCB1↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   B2M↓, 1,   CB2 / CNR2↓, 1,   CD4+↓, 1,   CD4+↑, 2,   cellSen?, 1,   cellSen↑, 1,   CLP↑, 1,   COX2/PTGS2↓, 13,   COX2/PTGS2↑, 1,   COX2/PTGS2∅, 1,   CRP↓, 1,   CTSZ↓, 1,   CXCR4↓, 4,   GNLY↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 3,   IFN-γ↑, 1,   IKKα↓, 2,   IKKα↑, 1,   p‑IKKα↓, 1,   IL1↓, 1,   IL10↓, 2,   IL12↓, 1,   IL12↑, 1,   IL18↓, 1,   IL1β↓, 8,   IL1β↑, 2,   IL1β∅, 1,   IL2↓, 2,   IL2↑, 1,   IL4↓, 2,   IL5↓, 1,   IL6↓, 13,   IL8↓, 2,   IL8↑, 1,   Imm↑, 12,   Imm↝, 1,   Inflam↓, 16,   Inflam↑, 1,   IRAK4↓, 1,   p‑IκB↓, 1,   JAK↓, 2,   JAK1↓, 1,   p‑JAK1↓, 1,   JAK2↓, 2,   p‑JAK2↓, 3,   LIF↑, 1,   LTA/TNF-β↑, 1,   M1↑, 1,   M2 MC↑, 1,   Macrophages↓, 1,   MCP1/CCL2↓, 1,   Neut↓, 2,   NF-kB?, 1,   NF-kB↓, 72,   NF-kB↑, 4,   NK cell↑, 1,   p65↓, 3,   p‑p65↓, 1,   ac‑p65↑, 2,   PD-1↓, 1,   PD-1↑, 1,   PD-L1↓, 7,   PD-L1↑, 2,   PGE2↓, 2,   SOCS-3↑, 1,   SOCS1↑, 1,   T-Cell↑, 3,   Th1 response?, 1,   Th1 response↑, 1,   TILs↑, 1,   TLR2↓, 1,   TLR4↓, 4,   TNF-α↓, 16,   TNF-α↑, 3,   TNF-α∅, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↑, 1,   pH↑, 2,   pH↝, 1,   e-pH↑, 6,   i-pH↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,   NLRP3↑, 1,   SNCG↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   BNP↓, 1,   CDK6↓, 3,   CDK6↑, 3,   COMT↓, 1,   CYP19↓, 3,   ER(estro)↓, 2,   ERα/ESR1↓, 9,   Estro↝, 1,   EstroRS/ERS↓, 1,   EstroRS/ERS↑, 1,   GR↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 2,   BioAv↓, 8,   BioAv↑, 13,   BioAv↝, 4,   BioEnh↑, 1,   ChemoSen?, 1,   ChemoSen↓, 2,   ChemoSen↑, 74,   ChemoSen∅, 2,   CT-I↓, 1,   CYP17A1↓, 1,   DDS↑, 2,   Dose?, 5,   Dose↓, 8,   Dose↑, 5,   Dose⇅, 1,   Dose↝, 75,   Dose∅, 7,   eff?, 2,   eff↓, 46,   eff↑, 147,   eff⇅, 1,   eff↝, 15,   eff∅, 1,   Half-Life?, 1,   Half-Life↓, 2,   Half-Life↑, 2,   Half-Life↝, 1,   MDR1↓, 2,   MDR1↑, 1,   MRP1/ABCC1↓, 2,   P450↓, 1,   P450↑, 1,   RadioS↑, 19,   selectivity?, 2,   selectivity↓, 4,   selectivity↑, 110,   selectivity↝, 1,   TET2↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALC∅, 1,   AR↓, 1,   ascitic↓, 1,   AST↓, 3,   B2M↓, 1,   BG↓, 1,   BloodF↓, 1,   BMD↑, 1,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA1↝, 1,   creat↓, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 10,   ERα/ESR1↓, 9,   EstroRS/ERS↓, 1,   EstroRS/ERS↑, 1,   EZH2↓, 3,   Ferritin↓, 2,   FOXM1↓, 3,   GutMicro↑, 4,   Hcy/homoC↓, 1,   HemoG↑, 1,   HER2/EBBR2↓, 13,   HOMA↓, 1,   hTERT/TERT↓, 5,   IL6↓, 13,   Ki-67↓, 15,   LDH↓, 9,   LDH↑, 1,   LDH∅, 1,   p‑LDH↓, 1,   e-LDH↑, 1,   Maspin↑, 1,   Myc↓, 3,   PD-L1↓, 7,   PD-L1↑, 2,   TP53↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 31,   antiNeop↑, 5,   antiNeop∅, 1,   AntiP↑, 1,   AntiTum↓, 1,   AntiTum↑, 23,   Appetite↑, 1,   cardioP↑, 7,   CardioT↓, 2,   CardioT↝, 1,   chemoP↓, 1,   chemoP↑, 17,   chemoPv↑, 9,   ChemoSideEff↓, 1,   cognitive↑, 1,   hepatoP↑, 5,   MKI67↑, 1,   neuroP↑, 1,   NKG2D↑, 1,   NP/CIPN↑, 2,   Obesity↓, 1,   OS?, 1,   OS↓, 2,   OS↑, 35,   Pain↓, 3,   Pin1↓, 1,   QoL↑, 5,   QoL∅, 1,   radioP↑, 5,   Remission↑, 3,   RenoP↑, 3,   Risk↓, 16,   Risk↑, 2,   Risk⇅, 1,   Risk∅, 1,   Sleep↑, 1,   Strength↑, 2,   Symptoms↓, 1,   toxicity↓, 11,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 39,   TumW↓, 12,   Weight↑, 3,   Weight∅, 4,   Wound Healing↓, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   CD8+↑, 4,   IRF3↓, 1,  
Total Targets: 1033

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   NLR↓, 1,   Stroke↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 22,   Catalase↑, 3,   GPx↑, 1,   GSH↑, 4,   HO-1↑, 3,   Keap1↓, 1,   lipid-P↓, 2,   MDA↓, 2,   NRF2↑, 4,   ROS↓, 15,   ROS↑, 1,   ROS∅, 9,   mt-ROS↑, 1,   SOD↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   FASN↓, 1,   GlucoseCon↑, 1,   Glycolysis↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAX↑, 1,   Bcl-2↓, 1,   Casp1?, 1,   Cyt‑c↑, 1,   iNOS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   other↓, 1,   other↝, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↑, 1,   HDAC3↓, 1,   NOTCH↓, 1,   STAT3↓, 2,   TumCG∅, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2∅, 1,   CEA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↑, 1,   NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   COX2/PTGS2↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 3,   IL10↑, 1,   IL1β↓, 2,   IL2↑, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 3,   Inflam↓, 9,   Inflam↑, 1,   NF-kB↓, 1,   NK cell↑, 1,   PGE2↓, 1,   TNF-α↓, 2,   TNF-α↑, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   ChAT↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 7,   BioAv↝, 1,   BioEnh↑, 1,   Dose↝, 1,   eff↓, 2,   Half-Life↓, 1,   Half-Life∅, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   CEA↓, 1,   IL6↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiP↑, 2,   AntiTum↑, 1,   cardioP↑, 7,   chemoP↑, 2,   cognitive↓, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↓, 1,   neuroP↑, 4,   radioP↑, 1,   toxicity?, 1,   toxicity↓, 26,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 9,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  
Total Targets: 101

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:4  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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