n-MYC Cancer Research Results

n-MYC, n-MYC Oncogene: Click to Expand ⟱
Source:
Type: Oncogene
The MYC proto-oncogenes are among the most commonly activated proteins in human cancer. N-myc is primarily implicated in high-grade neuroendocrine tumors (neuroblastoma and small-cell carcinomas) and those arising from the neural system (neuroblastoma, medulloblastoma, and glioblastoma).

It is a potent developmental regulator that controls proliferation, metabolism, ribosome biogenesis, and cell-cycle progression during embryogenesis—especially in neural crest–derived tissues.

Overexpression is generally associated with a more aggressive clinical course and lower survival rates.
neuroblastoma, Neuroblastoma: Click to Expand ⟱
Neuroblastoma is a type of cancer that develops in immature nerve tissue, usually affecting kids under age 5.
Scientific Papers found: Click to Expand⟱
2685- BBR,    Berberine induces neuronal differentiation through inhibition of cancer stemness and epithelial-mesenchymal transition in neuroblastoma cells
- in-vitro, neuroblastoma, NA
CSCs↓, CD133↓, β-catenin/ZEB1↓, n-MYC↓, SOX2↓, NOTCH2↓, Nestin↓, TumCCA↑, TumCP↓, CDK1↓, Cyc↓, Apoptosis↑, Bax:Bcl2↑, NCAM↓, MMP2↓, MMP9↓, *Smad1↑, *HSP70/HSPA5↑, *LAMs↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   Cyc↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CSCs↓, 1,   n-MYC↓, 1,   Nestin↓, 1,   NOTCH2↓, 1,   SOX2↓, 1,  

Migration ⓘ

MMP2↓, 1,   MMP9↓, 1,   NCAM↓, 1,   TumCP↓, 1,   β-catenin/ZEB1↓, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

Migration ⓘ

LAMs↑, 1,   Smad1↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: n-MYC, n-MYC Oncogene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:40  Cells:%  prod#:%  Target#:357  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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