APC Cancer Research Results

APC, adenomatous polyposis coli: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion. Mutations in the APC gene may result in colorectal cancer and desmoid tumors. The Apc protein is known to interact with several other proteins involved in signal transduction pathways, which regulate cell growth and differentiation.The Apc gene plays a key role in maintaining the integrity of the intestinal epithelium. It functions as a tumor suppressor by inhibiting the abnormal growth of cells and promoting their differentiation. Additionally, this gene helps regulate cell adhesion and migration, ensuring the proper development and function of organs and tissues.The Apc gene acts as a tumor suppressor by regulating the Wnt signaling pathway, which is essential for cell proliferation, differentiation, and self-renewal.
The loss of APC function can lead to dysregulation of the Wnt signaling pathway, contributing to tumorigenesis in various tissues.
neuroblastoma, Neuroblastoma: Click to Expand ⟱
Neuroblastoma is a type of cancer that develops in immature nerve tissue, usually affecting kids under age 5.
Scientific Papers found: Click to Expand⟱
6466- 1,8-Cin,    Transcriptome Analysis Reveals the Anti-Tumor Mechanism of Eucalyptol Treatment on Neuroblastoma Cell Line SH-SY5Y
- in-vitro, neuroblastoma, SH-SY5Y
AntiTum↑, TumCCA↑, PDGFRB↓, Myc↓, LEF1↓, BAD↑, APC↑, TBX3↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

TBX3↑, 1,  

Cell Death ⓘ

BAD↑, 1,   Myc↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PDGFRB↓, 1,  

Migration ⓘ

APC↑, 1,   LEF1↓, 1,  

Clinical Biomarkers ⓘ

Myc↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: APC, adenomatous polyposis coli
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:40  Cells:%  prod#:%  Target#:12  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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