PUMA Cancer Research Results

PUMA, p53 upregulated modulator of apoptosis: Click to Expand ⟱
Source:
Type: pro-apoptotic protein
The expression of PUMA is regulated by the tumor suppressor p53.

PUMA serves as an important proapoptotic factor that functions as a tumor suppressor by facilitating the elimination of damaged or aberrant cells. In many cancers, impaired induction of PUMA—often due to p53 dysfunction—correlates with treatment resistance and aggressive disease.


Thyroid, Thyroid: Click to Expand ⟱
Thyroid


Scientific Papers found: Click to Expand⟱
7513- FA,    Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP
- in-vitro, Thyroid, NA
cycD1/CCND1↓, URGCP/URG4↓, CDK4↓, CDK6↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, BAX↑, Casp3↑, Casp9↑, TIMP1↑, TumCI↓, TumCMig↓, TumCCA↑, Apoptosis↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

URGCP/URG4↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,   NOXA↑, 1,   PUMA↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   MMP9↓, 1,   TIMP1↑, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PUMA, p53 upregulated modulator of apoptosis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:43  Cells:%  prod#:%  Target#:430  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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