mTOR Cancer Research Results

mTOR, mammalian target of rapamycin: Click to Expand ⟱

Source: HalifaxProj (inhibit)

Type:

mTOR (mechanistic target of rapamycin) is a central regulator of cell growth, proliferation, metabolism, and survival. It is a serine/threonine kinase that integrates signals from nutrients, growth factors, and cellular energy status.
mTOR promotes protein synthesis and cell growth by activating downstream targets such as S6 kinase and 4E-BP1. In cancer, this pathway can become hyperactivated, leading to uncontrolled cell proliferation.

mTor Inhibitors:
-rapamycin (Sirolimus): classic natural product mTOR inhibitor
-Curcumin
-Resveratrol
-Epigallocatechin Gallate (EGCG)
-Honokiol

Laryn, Laryngeal Cancer: Click to Expand ⟱

Laryngeal cancer is a kind of cancer that can develop in any part of the larynx. It is typically a squamous-cell carcinoma, reflecting its origin from the epithelium of the larynx.

Scientific Papers found: Click to Expand⟱

2307-

CUR,

Cell-Type Specific Metabolic Response of Cancer Cells to Curcumin

in-vitro,

Colon,

HT29

20 μM for 24 hours

in-vitro,

Laryn,

FaDu

PKM2↓, Warburg↓, mTOR↓, Hif1a↓, Glycolysis↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1, PKM2↓, 1, Warburg↓, 1,

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: mTOR, mammalian target of rapamycin

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells