miR-375 Cancer Research Results

miR-375, miR-375: Click to Expand ⟱

Source:

Type:

miR-375 is a regulatory microRNA that generally functions as a tumour suppressor in head-and-neck and HPV-associated squamous cell carcinomas. It can suppress oncogenic transcripts involved in proliferation, survival, invasion, and extracellular-matrix degradation, including AEG-1/MTDH, IGF1R, JAK2, and YAP1. miR-375 may also directly or indirectly reduce HPV16/18 E6 and E7 expression, thereby supporting p53 and RB tumour- suppressor activity. miR-375 is frequently downregulated in these cancers; therefore, restoration or increased expression is generally considered the favourable direction in this context. Effects may differ by cancer type.

OS, Osteosarcoma: Click to Expand ⟱

Osteosarcoma is a type of cancer that starts in the bones. It is the most common type of bone cancer, and it usually affects children and young adults, although it can occur at any age. Osteosarcoma typically develops in the long bones of the body, such as the arms and legs, but it can also occur in other bones, including the pelvis and jaw.

Scientific Papers found: Click to Expand⟱

6990-

Form,

Formononetin induces apoptosis of human osteosarcoma cell line U2OS by regulating the expression of Bcl-2, Bax and MiR-375 in vitro and in vivo

vitro+vivo,

OS,

U2OS

TumCP↓, Apoptosis↑, Bcl-2↓, miR-375↓, BAX↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

miR-375↓, 1,

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1, BAX↑, 1, Bcl-2↓, 1,

Migration(tgid=13) ⓘ

TumCP↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: miR-375, miR-375

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells