SUV39H Cancer Research Results

SUV39H, suppressor of variegation 3-9 homolog: Click to Expand ⟱
Source:
Type:

SUV39H1/KMT1A (suppressor of variegation 3-9 homolog 1; H3K9 histone methyltransferase) is a SET-domain lysine methyltransferase that catalyzes methylation of histone H3 lysine 9, particularly formation of H3K9me3, a repressive chromatin mark associated with heterochromatin and transcriptional silencing. SUV39H1 regulates chromatin organization, genome stability, cellular differentiation, senescence and gene expression. In several cancers, increased SUV39H1 activity can promote epigenetic silencing of tumour-suppressive genes, stemness, proliferation and treatment resistance, although its role can vary by tumour context. In such settings, the cancer-associated direction is commonly up and the desired anticancer modulation is down or methyltransferase inhibition.



OS, Osteosarcoma: Click to Expand ⟱
Osteosarcoma is a type of cancer that starts in the bones. It is the most common type of bone cancer, and it usually affects children and young adults, although it can occur at any age. Osteosarcoma typically develops in the long bones of the body, such as the arms and legs, but it can also occur in other bones, including the pelvis and jaw.
Scientific Papers found: Click to Expand⟱
7174- CHA,    Inhibition of SUV39H1 reduces tumor angiogenesis via Notch1 in oral squamous cell carcinoma
- vitro+vivo, OS, OS-RC-2
SUV39H↓, TumCG↓, NOTCH1↓, CD31↓, VEGF↓, toxicity↓, Ki-67↓, angioG↓,
7163- CHA,    The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation
- in-vitro, Lung, A549 - in-vitro, OS, U2OS - in-vitro, CRC, HCT116 - in-vitro, CRC, HeLa - in-vivo, Ovarian, SKOV3
ROS↑, Trx↓, Apoptosis↑, TumCG↓, SUV39H↓, Hif1a↓, TumCP↓, eff↓, MMP↓, TumCG↓, Dose↝, toxicity↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

SUV39H↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,   Trx↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

NOTCH1↓, 1,   TumCG↓, 3,  

Migration(tgid=13) ⓘ

CD31↓, 1,   Ki-67↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 2,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SUV39H, suppressor of variegation 3-9 homolog
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:46  Cells:%  prod#:%  Target#:1592  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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