CycB/CCNB1 Cancer Research Results

CycB/CCNB1, Cyclin B: Click to Expand ⟱
Source:
Type:
When cyclin B levels are elevated, cells can enter M phase prematurely and strict control over cell division is lost, which is favorable for cancer development.
Cyclin B is a regulatory protein that plays a crucial role in cell cycle progression, particularly in the transition from the G2 phase to mitosis. Its expression levels can significantly impact cancer progression and patient prognosis.
Cyclin B expression is often elevated in various cancers and is generally associated with poor prognosis.
Cyclin B levels:
-Accumulate during S and G2
-Peak at mitotic entry
-Are rapidly destroyed at metaphase–anaphase transition via the APC/C ubiquitin ligase


OS, Osteosarcoma: Click to Expand ⟱
Osteosarcoma is a type of cancer that starts in the bones. It is the most common type of bone cancer, and it usually affects children and young adults, although it can occur at any age. Osteosarcoma typically develops in the long bones of the body, such as the arms and legs, but it can also occur in other bones, including the pelvis and jaw.
Scientific Papers found: Click to Expand⟱
6334- Cro,  Eug,  Rad,    Crocin and eugenol enhance radiosensitivity in oral squamous cell carcinoma cells via apoptotic pathways and cell cycle regulation. Type of study: in vitro
- in-vitro, OS, NA
tumCV↓, RadioS↑, TumCCA↑, BAX↑, Casp3↑, Bcl-2↓, cycA1/CCNA1↓, CycB/CCNB1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Cell Cycle & Senescence ⓘ

cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   TumCCA↑, 1,  

Drug Metabolism & Resistance ⓘ

RadioS↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CycB/CCNB1, Cyclin B
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:46  Cells:%  prod#:%  Target#:379  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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