HSF1 Cancer Research Results

HSF1, Heat Shock Factor 1: Click to Expand ⟱
Source:
Type:
HSF1 is the master regulator of the heat shock response. When cells experience stress (e.g., heat, oxidative stress, hypoxia), HSF1 becomes activated and translocates to the nucleus.
– Beyond facilitating the immediate survival response to stress, HSF1 also regulates genes involved in protein folding, degradation, and overall cellular quality control.

Oncogenic Functions:
– In cancer, HSF1 is frequently hijacked to support malignant progression. It can promote several cancer hallmarks including cell proliferation, survival, invasion, and metastasis.
– Elevated HSF1 expression and activity have been observed in various tumor types, including breast, prostate, lung, and colorectal cancers.
– Elevated HSF1 expression/activity is generally associated with poor clinical outcomes, aggressive cancer behavior, and therapeutic resistance.
Oral, Oral: Click to Expand ⟱
Oral
Scientific Papers found: Click to Expand⟱
2976- CUR,    Curcumin suppresses the proliferation of oral squamous cell carcinoma through a specificity protein 1/nuclear factor‑κB‑dependent pathway
- in-vitro, Oral, HSC3 - in-vitro, HNSCC, CAL33
tumCV↓, Sp1/3/4↓, p65↓, HSF1↓, NF-kB↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

HSF1↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,   p65↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HSF1, Heat Shock Factor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:47  Cells:%  prod#:%  Target#:1072  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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