FTH1 Cancer Research Results

FTH1, ferritin heavy chain: Click to Expand ⟱
Source:
Type:
Ferritin is a protein that stores iron in the body and is made up of two subunits, ferritin light chain (FTL) and ferritin heavy chain (FTH1).
Ferritin heavy chain 1 (FTH1) is one of the two subunits that make up the protein ferritin, which is responsible for storing iron in the body. FTH1 is encoded by the FTH1 gene, which is located on chromosome 11 in humans.

FTH1 expression is often upregulated in various cancers and is generally associated with a poorer prognosis.
Oral, Oral: Click to Expand ⟱
Oral
Scientific Papers found: Click to Expand⟱
2958- PL,    Natural product piperlongumine inhibits proliferation of oral squamous carcinoma cells by inducing ferroptosis and inhibiting intracellular antioxidant capacity
- in-vitro, Oral, HSC3
TumCP↓, lipid-P↑, ROS↑, DNMT1↑, FTH1↓, GPx4↓, eff↓, GSH↓, Ferroptosis↑, MDA↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   lipid-P↑, 1,   MDA↓, 1,   ROS↑, 1,  

Metal & Cofactor Biology ⓘ

FTH1↓, 1,  

Cell Death ⓘ

Ferroptosis↑, 1,  

DNA Damage & Repair ⓘ

DNMT1↑, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: FTH1, ferritin heavy chain
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:47  Cells:%  prod#:%  Target#:646  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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