tau Cancer Research Results

tau, tau: Click to Expand ⟱
Source:
Type:
In healthy neurons, tau binds to and stabilizes microtubules, which are essential for maintaining cell structure and facilitating axonal transport.

In AD, tau becomes abnormally hyperphosphorylated. This excessive phosphorylation reduces its affinity for microtubules, leading to destabilization of the cytoskeletal structure.
-Abnormal phosphorylated tau (p-tau) can be detected in cerebrospinal fluid (CSF) and blood plasma.
-Imaging techniques like tau PET scans can visualize tau deposits in the brain.
Natural Products targeting tau
-Curcumin                via GSK-3β inhibition
-Resveratrol             Activates SIRT1
-EGCG                    inhibits Tau, but BBB penetration is questionable
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
5798- CRMs,    Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders
- Review, Nor, NA - Review, AD, NA
*GutMicro↑, *neuroP↑, *eff↑, *Dose↝, *AMPK↑, *SIRT1↑, *mTOR↓, *NRF2↑, *p‑tau↓,
6208- CUR,    Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial
- Trial, Nor, NA
*memory↑, *Aβ↓, *tau↓,
3011- RosA,    Rosmarinic Acid Exhibits Anticancer Effects via MARK4 Inhibition
- in-vitro, GBM, SH-SY5Y - in-vitro, Lung, A549 - in-vitro, Nor, HEK293 - in-vitro, Nor, MCF10
MARK4↓, p‑tau↓, selectivity↑, *toxicity∅,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

MARK4↓, 1,  

Synaptic & Neurotransmission ⓘ

p‑tau↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

NRF2↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   SIRT1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,  

Synaptic & Neurotransmission ⓘ

tau↓, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

memory↑, 1,   neuroP↑, 1,   toxicity∅, 1,  
Total Targets: 13

Scientific Paper Hit Count for: tau, tau
1 Calorie Restriction Mimetics
1 Curcumin
1 Rosmarinic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1231  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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