Sepsis Cancer Research Results

Sepsis, Sepsis: Click to Expand ⟱
Source:
Type:
Sepsis is a life-threatening medical condition that occurs when the body’s response to an infection causes widespread inflammation. This uncontrolled inflammatory response can lead to tissue damage, organ failure, and, in severe cases, death.

-Treatment options PKM2, Glycolysis and HIF1α inhibitors.

-Chemotherapy, radiation therapy, and immunosuppressive drugs can further weaken the immune system, making patients more susceptible to infections that can lead to sepsis.

-AgNPs have demonstrated antimicrobial effects against a wide range of pathogens including bacteria, fungi, and viruses. Since infections are the primary trigger for sepsis, their ability to reduce microbial loads has been of significant interest.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
2347- CAP,    Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis
- in-vivo, Nor, NA - in-vitro, Nor, RAW264.7
*PKM2↓, *LDHA↓, *Warburg↓, *COX2↓, *Sepsis↓, *Inflam↓, *ECAR↓, *OCR↑,
2348- CAP,    Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry
- Analysis, Nor, NA
Warburg↓, *PKM2↓, *COX2↓, *Inflam↓, *Sepsis↓, *AMPK↑, *PKA↑, *mitResp↑, *FAO↑, *FASN↓, *PGM1?, *ATP↑, *ROS↓,
6421- CUR,    Curcumin simultaneously improves mitochondrial dynamics and myocardial cell bioenergy after sepsis via the SIRT1-DRP1/PGC-1α pathway
- in-vivo, Nor, NA
*SIRT1↓, *PGC-1α↑, *NRF2↑, *DRP1/DNM1L↓, *Sepsis↓, *OS↑, *cardioP↑,
6877- FA,    The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *hepatoP↑, *DNAdam↓, *Sepsis↓, *MDA↓, *GSH↑, *GPx↑, *ROS↓,
2339- QC,    Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation
- in-vivo, Nor, NA
*Inflam↓, *antiOx↑, *NLRP3↓, *Sepsis↓, *PKM2↓, *SIRT1↓,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

Warburg↓, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   GPx↑, 1,   GSH↑, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   DRP1/DNM1L↓, 1,   mitResp↑, 1,   OCR↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   ECAR↓, 1,   FAO↑, 1,   FASN↓, 1,   LDHA↓, 1,   PGM1?, 1,   PKM2↓, 3,   SIRT1↓, 2,   Warburg↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Migration(tgid=13) ⓘ

PKA↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 2,   Inflam↓, 4,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cardioP↑, 1,   hepatoP↑, 1,   OS↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 5,  
Total Targets: 30

Scientific Paper Hit Count for: Sepsis, Sepsis
2 Capsaicin
1 Curcumin
1 Ferulic acid
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1264  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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