CYP1B1 Cancer Research Results

CYP1B1, Cytochrome P450 Family 1 Subfamily B Member 1: Click to Expand ⟱
Source:
Type:
CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) is a xenobiotic- and hormone-metabolizing enzyme involved in oxidative metabolism, particularly of estrogens and procarcinogens.
-overexpressed in cancer, with poor prognosis
-A striking feature of CYP1B1 is its consistent overexpression in many tumors with minimal expression in adjacent normal tissue.
CYP1B1 overactivity contributes to cancer by:
-Increasing DNA damage burden
-Promoting genomic instability
-Supporting hormone-driven proliferation
-Modulating local redox balance (Generates reactive oxygen species (ROS))


Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
6595- Anamu,    Dibenzyl trisulfide binds to and competitively inhibits the cytochrome P450 1A1 active site without impacting the expression of aryl hydrocarbon receptor
- in-vivo, Nor, NA
CYP1A1↓, CYP1B1↓, chemoPv↑,
7470- Hops,    Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A)
- NA, Nor, MCF10
*CYP1A1↓, *CYP1B1↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

CYP1A1↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

CYP1B1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

CYP1A1↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

CYP1B1↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: CYP1B1, Cytochrome P450 Family 1 Subfamily B Member 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1345  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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