ACE Cancer Research Results

ACE, Angiotensin-Converting Enzyme 1: Click to Expand ⟱
Source:
Type:

ACE - Angiotensin-Converting Enzyme 1

Abbreviation: ACE, ACE1, CD143

Type: Zinc metallopeptidase / renin-angiotensin system enzyme

Function: Converts angiotensin I to the biologically active vasoconstrictor angiotensin II and degrades bradykinin. ACE regulates blood pressure, vascular function, inflammation, oxidative stress, fibrosis, angiogenesis, and tissue remodeling through the classical renin-angiotensin system.

Cancer: ↑ Increased ACE/angiotensin II signaling can promote tumor-associated inflammation, angiogenesis, proliferation, fibrosis, invasion, and metastasis, particularly through downstream AT1R signaling. ACE inhibition can suppress tumor growth and angiogenic signaling in several experimental cancer models.

Alzheimer's Disease: ↕ Context-dependent. ACE participates in potentially harmful angiotensin II-mediated vascular, oxidative, and inflammatory signaling, but also directly degrades amyloid-β and can convert Aβ42 toward Aβ40. ACE levels and activity therefore show complex compartment-dependent relationships with Alzheimer's pathology.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
7367- HibSad,  CUR,  Moringa,  CAP,  RosA  Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases
- Review, Nor, NA
*ACE↓,
7360- HibSad,    Inhibition of angiotensin convertin enzyme (ACE) activity by the anthocyanins delphinidin- and cyanidin-3-O-sambubiosides from Hibiscus sabdariffa
- Study, Nor, NA
*diuretic↑, *BP↓, *ACE↓,
7368- RS,  Amla,  CS,  Pom,  MP  Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases
- Study, Nor, NA
*ACE↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

ACE↓, 3,   diuretic↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,  
Total Targets: 3

Scientific Paper Hit Count for: ACE, Angiotensin-Converting Enzyme 1
2 Hibiscus sabdariffa
1 Curcumin
1 Moringa oleifera
1 Capsaicin
1 Rosmarinic acid
1 Rauwolfia serpentina/Indian Snakeroot
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Pomegranate/Punica granatum
1 Mucuna pruriens/Velvet Bean
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1629  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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