MMP7 Cancer Research Results

MMP7, metalloproteinase-7: Click to Expand ⟱
Source:
Type:
MMP-7, or matrix metalloproteinase-7, is an enzyme that plays a significant role in the degradation of extracellular matrix components. It is part of a larger family of matrix metalloproteinases (MMPs) that are involved in various physiological and pathological processes, including tissue remodeling, wound healing, and inflammation.
MMP-7 can facilitate tumor invasion and metastasis by breaking down the extracellular matrix, allowing cancer cells to migrate and invade surrounding tissues.
Elevated levels of MMP-7 have been associated with poor prognosis in various cancers, including colorectal, breast, and lung cancers.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
6897- FIS,    Fisetin: A Dietary Antioxidant for Health Promotion
- Review, Nor, NA
*chemoPv↑, *neuroP↑, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, angioG↓, TumCG↓, uPA↓, MMP1↓, tumCV↓, PTEN↑, PI3K↓, p‑Akt↓, AMPK↑, mTOR↓, EGFR↓, NF-kB↓, COX2↓, PGE2↓, Wnt↓, β-catenin/ZEB1↓, TCF↓, cycD1/CCND1↓, MMP7↓, RadioS↑, PSA↓, Securin↓, TumCCA↑, XIAP↓, *ERK↑, *p‑CREB↑, *memory↑, *GSH↑, *Inflam↓, *5LO↓,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, eff↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
2132- TQ,    Thymoquinone treatment modulates the Nrf2/HO-1 signaling pathway and abrogates the inflammatory response in an animal model of lung fibrosis
- in-vivo, Nor, NA
*Weight∅, *antiOx↑, *lipid-P↓, *MMP7↓, *Casp3↓, *BAX↓, *TGF-β↓, *Diff↑, *NRF2↓, *HO-1↓, *NF-kB↓, *IκB↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   LDH↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 1,   Casp3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 2,   Securin↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 2,   PI3K↓, 1,   PTEN↑, 1,   TCF↓, 1,   TumCG↓, 3,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   MMP1↓, 1,   MMP2↓, 1,   MMP7↓, 2,   MMP9↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   uPA↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   EGFR↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   NF-kB↓, 3,   PGE2↓, 1,   PSA↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,   RadioS↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   Ki-67↓, 1,   LDH↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,  
Total Targets: 42

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   GSH↑, 2,   HO-1↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   NRF2↓, 1,   NRF2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑CREB↑, 1,   PPARγ↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Casp3↓, 1,   MAPK↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   ERK↑, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   MMP7↓, 1,   TGF-β↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   Inflam↑, 1,   IκB↑, 1,   NF-kB↓, 1,   PGE2↓, 1,   TLR2↓, 1,   TLR4↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   chemoPv↑, 1,   memory↑, 1,   neuroP↑, 2,   toxicity↓, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 33

Scientific Paper Hit Count for: MMP7, metalloproteinase-7
1 Fisetin
1 Magnolol
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:202  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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