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| Lipid peroxidation is a chain reaction process in which free radicals (often reactive oxygen species, or ROS) attack lipids containing carbon-carbon double bonds, especially polyunsaturated fatty acids. This attack results in the formation of lipid radicals, peroxides, and subsequent breakdown products. Lipid peroxidation can cause damage to cell membranes, leading to increased permeability and disruption of cellular functions. This damage can initiate a cascade of events that may contribute to carcinogenesis. The byproducts of lipid peroxidation, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), can form adducts with DNA, leading to mutations. These mutations can disrupt normal cellular processes and contribute to the development of cancer. Lipid peroxidation damages cell membranes, disrupts cellular functions, and can trigger inflammatory responses. It is a marker of oxidative stress and is implicated in many chronic diseases. Negative Prognostic Indicator: In many cancers, high levels of lipid phosphates, particularly S1P, are associated with poor prognosis, indicating a more aggressive tumor phenotype and potential resistance to therapy. Mixed Evidence: The prognostic significance of lipid phosphates can vary by cancer type, with some studies showing that their expression may not always correlate with adverse outcomes. |
| Normal Healthy |
| 5419- | ASTX, | Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications |
| - | Review, | Nor, | NA |
| 5365- | AV, | Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications |
| - | Review, | Nor, | NA | - | Review, | IBD, | NA | - | Review, | Diabetic, | NA |
| 2689- | BBR, | Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells |
| - | in-vitro, | Nor, | PC12 | - | in-vitro, | AD, | NA | - | in-vitro, | Stroke, | NA |
| 6517- | BCP, | β-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFκB and Nrf2/HO1/NQO1 Pathways |
| - | in-vivo, | Nor, | NA |
| 3510- | Bor, | Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks |
| - | in-vivo, | Nor, | NA |
| 1425- | Bos, | Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2/HO-1 Defense Pathway |
| - | in-vivo, | Nor, | NA |
| - | Review, | Nor, | NA |
| - | in-vivo, | Nor, | NA |
| - | in-vivo, | Nor, | NA |
| 5881- | CAR, | Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties |
| - | Review, | Nor, | NA |
| 6662- | Cen, | Assessment report on Centella asiatica (L.) Urban, herba |
| - | Review, | Nor, | NA |
| 6080- | CHL, | VitC, | Protective Effects of Sodium Copper Chlorophyllin and/or Ascorbic Acid Against Barium Chloride-Induced Oxidative Stress in Mouse Brain and Liver |
| - | in-vivo, | Nor, | NA |
| 6084- | CHOC, | Cocoa Polyphenols and Their Potential Benefits for Human Health |
| - | Review, | Nor, | NA | - | Review, | Stroke, | NA | - | Review, | IBD, | NA |
| 6128- | CHr, | Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential |
| - | Review, | Nor, | NA | - | Review, | Var, | NA | - | Review, | AD, | NA |
| 6623- | Cic, | MTX, | Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling |
| - | in-vivo, | Nor, | NA |
| 6374- | CPLE, | Antiviral & platelet-protective properties of Carica papaya in dengue |
| - | Review, | Nor, | NA |
| 2810- | CUR, | Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials |
| - | Review, | Nor, | NA |
| 6357- | DRE, | New Perspectives on the Effect of Dandelion, Its Food Products and Other Preparations on the Cardiovascular System and Its Diseases |
| - | Review, | Nor, | NA |
| 6353- | DRE, | Cisplatin, | Insights Into Protective Mechanisms of Dandelion Leaf Extract Against Cisplatin-Induced Nephrotoxicity in Rats: Role of Inhibitory Effect on Inflammatory and Apoptotic Pathways |
| - | in-vivo, | Nor, | NA |
| 3222- | EGCG, | Epigallocatechin gallate and mitochondria—A story of life and death |
| - | Review, | Nor, | NA |
| 6335- | Eug, | Eugenol with antioxidant activity inhibits MMP-9 related to metastasis in human fibrosarcoma cells |
| - | in-vitro, | Nor, | NA |
| 2861- | FIS, | The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress |
| - | Review, | Nor, | NA | - | Review, | Stroke, | NA | - | Review, | Park, | NA |
| - | in-vitro, | CRC, | HT-29 | - | in-vitro, | Nor, | CCD841 |
| 2907- | LT, | Protective effect of luteolin against oxidative stress‑mediated cell injury via enhancing antioxidant systems |
| - | in-vitro, | Nor, | NA |
| 3531- | Lyco, | Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system |
| - | in-vivo, | Nor, | NA |
| 5016- | PEITC, | Phenethyl Isothiocyanate (PEITC) interaction with Keap1 activates the Nrf2 pathway and inhibits lipid accumulation in adipocytes |
| - | in-vitro, | Nor, | NA |
| 3004- | RosA, | Rosmarinic acid counteracts activation of hepatic stellate cells via inhibiting the ROS-dependent MMP-2 activity: Involvement of Nrf2 antioxidant system |
| - | in-vitro, | Nor, | HSC-T6 |
| 4613- | Se, | Rad, | Effect of Selenium and Selenoproteins on Radiation Resistance |
| - | Review, | Nor, | NA |
| 3315- | SIL, | Silymarin alleviates docetaxel-induced central and peripheral neurotoxicity by reducing oxidative stress, inflammation and apoptosis in rats |
| - | in-vivo, | Nor, | NA |
| 3400- | TQ, | Chemo, | Thymoquinone Ameliorates Carfilzomib-Induced Renal Impairment by Modulating Oxidative Stress Markers, Inflammatory/Apoptotic Mediators, and Augmenting Nrf2 in Rats |
| - | in-vitro, | Nor, | NA |
| 3398- | TQ, | 5-FU, | Impact of thymoquinone on the Nrf2/HO-1 and MAPK/NF-κB axis in mitigating 5-fluorouracil-induced acute kidney injury in vivo |
| - | in-vivo, | Nor, | NA |
| 2114- | TQ, | Anti-Aging Effect of Nigella Sativa Fixed Oil on D-Galactose-Induced Aging in Mice |
| - | in-vivo, | Nor, | NA |
| 2113- | TQ, | Potential role of Nigella sativa (NS) in abating oxidative stress-induced toxicity in rats: a possible protection mechanism |
| - | in-vivo, | Nor, | NA |
| 2132- | TQ, | Thymoquinone treatment modulates the Nrf2/HO-1 signaling pathway and abrogates the inflammatory response in an animal model of lung fibrosis |
| - | in-vivo, | Nor, | NA |
| 2136- | TQ, | Nigella sativa and thymoquinone suppress cyclooxygenase-2 and oxidative stress in pancreatic tissue of streptozotocin-induced diabetic rats |
| - | in-vivo, | Nor, | NA |
| 2086- | TQ, | Cardioprotective effects of Nigella sativa oil on cyclosporine A-induced cardiotoxicity in rats |
| - | in-vivo, | Nor, | NA |
| 2088- | TQ, | Nigella sativa L. and Its Bioactive Constituents as Hepatoprotectant: A Review |
| - | Review, | Nor, | NA |
| 4858- | Uro, | The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent |
| - | in-vitro, | Nor, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:49 Cells:% prod#:% Target#:453 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid