hepatoP Cancer Research Results

hepatoP, L,hepatoprotective: Click to Expand ⟱
Source:
Type:
Hepatoprotective is the ability of a chemical substance to prevent damage to the liver.

Grapefruit:
-hepatoprotective potential has emerged from the study of naringenin and naringin.
Blueberries/cranberries:
-proanthocyanidins
Grape:
Nopal (Cactus pear) and tuna (Cactus pear fruit) “Opuntia ficus-indica”:
Chamomile (Matricaria chamomilla or Chamomilla recutita):
Silymarin (Silybum marianum):
Blue green algae spirulina :
Propolis (bee glue):

POLYSACCHARIDES
β-glucans
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
4442- ,    Anticancer and Hepatoprotective Role of Selenium Nanoparticles against
- in-vivo, Liver, HepG2 - NA, Nor, NA
*hepatoP↑, AntiCan↑,
6477- 1,8-Cin,    Protective effect of 1, 8-cineole (eucalyptol) against lead-induced liver injury by ameliorating oxidative stress and inflammation and modulating TLR4/MyD88/NF-κB signaling
- in-vivo, Nor, NA
*MDA↓, *GSH↑, *GPx↑, *Inflam↓, *TLR4↓, *MyD88↓, *NF-kB↓, *AST↓, *ALAT↓, *hepatoP↑, *ROS↓,
2207- AgNPs,  TQ,    Protective effects of Nigella sativa L. seeds aqueous extract-based silver nanoparticles on sepsis-induced damages in rats
- in-vivo, Nor, NA
*eff↑, *RenoP↑, *hepatoP↑, *MDA↓, *SOD↑, *GSH↑, *TNF-α↓, *IL1β↓,
2206- AgNPs,  RES,    ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION
- in-vivo, Nor, NA
*hepatoP↑, *Inflam↓, *NF-kB↓, *VEGF↓, *SIRT1↑, *ROS↓, *Dose↝, *Catalase↑, *MDA↓, *MPO↓, *NO↓, *ALAT↓, *AST↓, *antiOx↑,
2205- AgNPs,    Potential protective efficacy of biogenic silver nanoparticles synthesised from earthworm extract in a septic mice model
- in-vivo, Nor, NA
*Dose↝, *eff↑, *RenoP↑, *antiOx↑, *MDA↓, *NO↓, *hepatoP↑, *toxicity↝, *GSH↑, *SOD↑, *GSTs↑, *Catalase↑,
6763- AL,    Revealing the Therapeutic Uses of Garlic (Allium sativum) and Its Potential for Drug Discovery
- Review, Nor, NA
*Inflam↓, *AntiBio↑, *AntiDiabetic↑, *hepatoP↑, *antiOx↑, *AntiFungal↑, *Wound Healing↑, *other↑, *BP↓, *LDL↓, *AntiAg↑, *cognitive↑, *memory↑, Risk↑, *COX1↓, *TXA2↓,
3446- ALA,  CUR,    The Potential Protective Effect of Curcumin and α-Lipoic Acid on N-(4-Hydroxyphenyl) Acetamide-induced Hepatotoxicity Through Downregulation of α-SMA and Collagen III Expression
- in-vivo, Nor, NA
*hepatoP↑, *α-SMA↓, *COL3A1↓, *ROS↓, *GSH↑, *ALAT↓, *AST↓, *ALP↓, *MDA↓,
7398- Amla,    Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis
- in-vivo, Nor, NA
*hepatoP↑,
2317- Api,    Apigenin intervenes in liver fibrosis by regulating PKM2-HIF-1α mediated oxidative stress
- in-vivo, Nor, NA
*hepatoP↑, *PKM2↓, *Hif1a↓, *MDA↓, *Catalase↓, *GSH↑, *SOD↑, *GPx↑, *TAC↑, *α-SMA↓, *Vim↓, *ROS↓,
3170- Ash,    Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms
- in-vitro, Nor, NRK52E - in-vivo, NA, NA
*RenoP↑, *hepatoP↑, *creat↓, *BUN↓, *uricA↓, *Apoptosis↓, *α-SMA↓,
2610- Ba,    Hepatoprotective effects of baicalein against CCl4-induced acute liver injury in mice
- in-vivo, Nor, NA
*TNF-α↑, *IL6↑, *hepatoP↑,
2607- Ba,  SIL,    Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2
- in-vivo, Nor, NA
*BioEnh↑, *hepatoP↑, *antiOx↑, *Inflam↓,
2613- Ba,    Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice
- in-vivo, Nor, NA
*hepatoP↑, *MDA↓, *SOD↑, *Catalase↑, *GSH↑, *MAPK↓, *p‑JAK2↓, *p‑STAT3↓, *ALAT↓, *AST↓, *ROS↓, *antiOx↑,
5506- Ba,    Improved Bioavailability and Hepatoprotective Activity of Baicalein Via a Self-assembled Solutol HS15 Micelles System
- in-vivo, Nor, NA
*AST↓, *ALAT↓, *GSH↓, *SOD↓, *MDA↓, *hepatoP↑, *Inflam↓, BioAv↑,
5248- Ba,  BA,  doxoR,    Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, Nor, HUVECs
toxicity↝, ChemoSen↑, selectivity↑, Apoptosis↑, necrosis↑, MMP↓, DNAdam↑, cl‑PARP↑, MRP1/ABCC1↓, Bcl-2↓, hepatoP↑, cardioP↑, BioAv↝,
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,
6556- BSB,    A Comprehensive Study of Therapeutic Applications of Chamomile
- Review, Nor, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiBio↑, *hepatoP↑, *AntiCan↑, *other↝, *toxicity↓, *Wound Healing↓, *Dose↝, *Dose↝, *eff↝, *ROS↓, *TNF-α↓, *IL6↓, *other↝, *AST↓, *ALAT↓,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2↓, *Dose↝,
5926- CAR,    An Updated Review of Research into Carvacrol and Its Biological Activities
- Review, Nor, NA - Review, AD, NA - Review, asthmatic, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *toxicity↓, *Pain↓, *TRPV3↑, *NRF2↑, *Ca+2↑, *ATP↑, *5LO↓, *COX2↓, PGE2↓, *hepatoP↑, *AntiAg↑, *Diar↓, *cardioP↑, *other↝, *chemoPv↑, *cognitive↑, *AChE↓, *GastroP↑, *eff↑, *BChE↓, *CRP↓,
6658- Cen,    A Comparative Study of the Hepatoprotective Effect of Centella asiatica Extract (CA-HE50) on Lipopolysaccharide/d-galactosamine-Induced Acute Liver Injury in C57BL/6 Mice
- in-vivo, Nor, NA
*hepatoP↑,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP/DDIT3↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
6011- CGA,    Chlorogenic Acid’s Role in Metabolic Health: Mechanisms and Therapeutic Potential
- Review, Nor, NA
*BioAv↓, *antiOx↑, *Inflam↓, *Bacteria↓, *hepatoP↑, *cardioP↑, *neuroP↑, *ROS↓, *NF-kB↓, *NRF2↑, *Obesity↓, *GutMicro↑, *AntiAg↑, *cardioP↑, *AntiDiabetic↑, *NLRP3↓, *OCLN↓, *VEGF↓, BioAv↝,
6080- CHL,  VitC,    Protective Effects of Sodium Copper Chlorophyllin and/or Ascorbic Acid Against Barium Chloride-Induced Oxidative Stress in Mouse Brain and Liver
- in-vivo, Nor, NA
*neuroP↑, *MDA↓, *hepatoP↑, *IronCh↑, *ROS↓, *lipid-P↓,
6105- Chol,    Choline supplementation protects against liver damage by normalizing cholesterol metabolism in Pemt/Ldlr knockout mice fed a high-fat diet
- in-vivo, Nor, NA
*hepatoP↑,
6623- Cic,  MTX,    Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling
- in-vivo, Nor, NA
*antiOx↑, *hepatoP↑, *ROS↓, *lipid-P↓, *TAC↑, *NRF2↑, *HO-1↑, *NQO1↑, *PPARγ↑, *Inflam↓, *Apoptosis↓, *Bcl-2↑, *BAX↓, *Cyt‑c↓, *Casp3↓,
6300- Cro,    Interaction of saffron and its constituents with Nrf2 signaling pathway: A review
- Review, Nor, NA - Review, Arthritis, NA
*antiOx↑, *Inflam↓, *AntiTum↑, *hepatoP↑, *cardioP↑, *neuroP↑, *NRF2↑, *NF-kB↓, *iNOS↓, *COX2↓, *IL6↓, *IL10↓, *IL1β↓, *TNF-α↓, *HO-1↑, ROS↑, NQO1↑, NRF2↑, HO-1↑, NQO2↑, LDHA↓, ATP↓, *hepatoP↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *ROS↓, *cardioP↑, *ER Stress↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *Apoptosis↓, *miR-34a↓, *SIRT1↑, chemoP↑,
6299- Cro,    Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *ALP↓, *MDA↓, *ROS↓, *Catalase↑, *SOD↑, *IL6↓, *IL1β↓, *TNF-α↓, *NRF2↑, *HO-1↑, *NADPH↑, *NQO1↑, *hepatoP↑, *GSH↑,
6297- Cro,    Crocetin Exerts Its Anti-inflammatory Property in LPS-Induced RAW264.7 Cells Potentially via Modulation on the Crosstalk between MEK1/JNK/NF-κB/iNOS Pathway and Nrf2/HO-1 Pathway
- in-vitro, Nor, RAW264.7
*NO↓, *iNOS↓, *Inflam↓, *MEK↓, JNK↓, NF-kB↓, NRF2↑, HO-1↑, hepatoP↑, neuroP↑,
6529- CRV,    D-Carvone Attenuates CCl4-Induced Liver Fibrosis in Rats by Inhibiting Oxidative Stress and TGF-ß 1/SMAD3 Signaling Pathway
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *MDA↓, *SOD↑, *GSH↑, *TAC↑, *eff↑, *TGF-β1↓, *SMAD3↓, *MMP9↑, *NRF2↑, *antiOx↑, *hepatoP↑, *Inflam↓, *NF-kB↓, *NO↓, *cAMP↑, *ROS↓,
7421- CS,    Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial
- Trial, Nor, NA
*hepatoP↑, *Dose↝, *toxicity↓, *BloodF↑, *ALAT↓, *AST↓, *Bil↓, *LDL↓, *HDL↓, *TG/TAG↓,
7429- CS,    Functional and Therapeutic Potential of Cynara scolymus in Health Benefits
- Review, Nor, NA - Review, IBD, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *ICAM-1↓, *IL1β↓, *IL6↓, *MUC1↑, *OCLN↑, *IBI↑, *ROS↓, *cardioP↑, *SOD↑, *GPx↑, *GSH↑, *TG/TAG↓, *LDL↓, *neuroP↑, *5HT↑, *BDNF↑,
6663- DFE,    Nutraceuticals of Phoenix dactylifera L.: Physicochemistry, Nutritional Value and Therapeutic Potential
- Review, Nor, NA - Review, AD, NA
*antiOx↑, *Inflam↓, *AntiBio↑, *AntiDiabetic↑, *AntiCan↑, *AntiArt↑, *neuroP↑, *hepatoP↑, *GastroP↑, *other↝, *cardioP↑, *cognitive↑, *ROS↓, *memory↑, *other↝, *SOD↑, *Catalase↑, *GSH↑, *GA↑, *Catechins↑, *FA↑, *QC↑, Api↑, *CA↑, *Imm↑, *Phen↑, *IL1β↓, *TGF-β↓, *COX1↓, *COX2↓, TumCP↓, Casp3↑, TumMeta↓, *GutMicro↑,
6715- dietF,    Are Fermented Foods Effective against Inflammatory Diseases?
- Review, Nor, NA
*Imm↑, *GastroP↑, *Inflam↓, AntiCan↑, *AntiBio↑, *hepatoP↑, *CD4+↑, *IFN-γ↓, *IL17↓, *GutMicro↑, *antiOx↑, *AST↓, *ALAT↓, *HDL↑, *LDL↓, *ROS↓, *lipid-P↓, *Inflam↓, *Aβ↓,
7240- EGb 761,    EGb 761 protects liver mitochondria against injury induced by in vitro anoxia/reoxygenation
- in-vitro, Nor, NA
*ATP↑, *ROS↓, *hepatoP↑,
6825- EMD,    Advances in the pharmacological effects and molecular mechanisms of emodin in the treatment of metabolic diseases
- Review, Nor, NA
*Inflam↓, *AntiTum↑, *Bacteria↓, *Imm↑, *glucose↓, *RenoP↑, *TLR4↓, *MyD88↓, *NLRP3↓, *NF-kB↓, *PI3K↓, *mTOR↓, *GSK‐3β↓, *Hif1a↓, *VEGF↓, *GutMicro↑, *Obesity↓, *AntiDiabetic↑, *AMPK↑, *PPARγ↑, *PPARγ↓, *toxicity↝, *hepatoP↑, *AST↓, *ALAT↓,
6814- EMD,    Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics
- Review, Nor, NA
AntiCan↑, *hepatoP↑, *Inflam↑, *antiOx↑, *AntiBio↑, *BioAv↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, CSCs↓, NOTCH↓, β-catenin/ZEB1↓, STAT3↓, TumCCA↑, *TNF-α↓, IL6↓, IL1β↓, *MMP9↓, *HO-1↑, cMyc↓, Mcl-1↓,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, eff↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6836- EMD,    Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers
- Review, Nor, NA
*antiOx↑, *neuroP↑, *Inflam↓, *hepatoP↑, AntiTum↑, *Bacteria↓, *diuretic↑, *AntiDiabetic↑, *BioAv↝, *NF-kB↓, *AMPK↑, *JAK↓, *STAT3↓, *ROS↓, *lipid-P↓, ROS↑, TumCCA↑, CycB/CCNB1↓, BAX↑, Bcl-2↓, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, Apoptosis↑, P53↑,
6379- Eug,    Safety assessment of a standardized polyphenolic extract of clove buds: Subchronic toxicity and mutagenicity studies
- in-vivo, Nor, NA
*toxicity∅, *Dose↑, *Bacteria↓, *Inflam↓, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *AntiThr↑,
6871- FA,  Sesame,    Nano-encapsulated ferulic acid in sesame protein isolate alleviates acrylamide-induced liver toxicity and genotoxicity in rats via oxidative stress and DNA damage modulation
- in-vivo, Nor, NA
*GSH↑, *GPx↑, *SOD↓, *Catalase↑, *MDA↓, *IL6↓, *TNF-α↑, *DNAdam↓, *hepatoP↑, *BioAv↓, *BioAv↑,
6877- FA,    The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *hepatoP↑, *DNAdam↓, *Sepsis↓, *MDA↓, *GSH↑, *GPx↑, *ROS↓,
6878- FA,    Ferulic acid modulates fluoride-induced oxidative hepatotoxicity in male Wistar rats
- in-vivo, Nor, NA
*lipid-P↓, *hepatoP↑,
6886- FA,  MTX,    Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats
- in-vivo, Nor, NA
*hepatoP↑, *ROS↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *p65↓, *BAX↓, *Casp3↓, *NRF2↑, *HO-1↑, *PPARγ↑, *Inflam↓,
6430- FEO,    Foeniculum vulgare: A comprehensive review of its traditional use, phytochemistry, pharmacology, and safety
- Review, Nor, NA
*Dose↝, *Bacteria↓, *hepatoP↑, *antiOx↑, *AntiThr↑, *AntiDiabetic↑, *toxicity↝,
7156- GI,    Ginger-derived nanoparticles protect against alcohol-induced liver damage
- in-vivo, Nor, NA
*hepatoP↑, *NRF2↑, *ROS↑,
7487- H2,    A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives
- Review, Nor, NA
*Inflam↓, *antiOx↓, *Stress↓, *Dose↝, *cardioP↑, *GastroP↑, *BBB↑, *eff↑, *toxicity↓, *Dose↝, *hepatoP↑, *ROS↓, *SOD↑, *TBARS↓, *HDL↑, *LDL↓, *Obesity↓, *GSH↑, *TNF-α↓, *GutMicro↑, *DNAdam↓, *γH2AX↓, *p‑p38↓, *NF-kB↓,
7508- HCAs,    Natural Sources, Pharmacokinetics, Biological Activities and Health Benefits of Hydroxycinnamic Acids and Their Metabolites
- Review, Nor, NA
*Dose↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *BioAv↓, *antiOx↑, *ROS↓, *Inflam↓, *neuroP↑, *cardioP↑, *hepatoP↑,
7362- HibSad,    The effect of a water extract and anthocyanins of hibiscus sabdariffa L on paracetamol-induced hepatoxicity in rats
- in-vivo, Nor, NA
*Dose↝, *hepatoP↑,
6482- LIN,    Pharmacological and molecular insights into linalool-rich Coriandrum sativum essential oil: Anticonvulsant, analgesic, anti-inflammatory, and antioxidant potential in rodent models
- Review, Nor, NA
IL1β↓, IL6↓, hepatoP↑, Inflam↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,

Showing Research Papers: 1 to 50 of 71
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 71

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↑, 2,   NQO1↑, 1,   NRF2↑, 2,   ROS↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   MMP↓, 2,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   Glycolysis↓, 2,   LDHA↓, 1,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 3,   BAX↑, 3,   Bcl-2↓, 4,   Casp3↑, 2,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   Fas↑, 1,   JNK↓, 1,   JNK↑, 1,   MAPK↑, 1,   Mcl-1↓, 1,   MOMP↑, 1,   necrosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   NQO2↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 2,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CycB/CCNB1↓, 1,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   CSCs↓, 3,   EMT↓, 1,   miR-34a↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   OCT4↓, 1,   SOX2↓, 1,   STAT3↓, 3,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,   Slug↓, 1,   TRIB3↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCP↓, 2,   TumMeta↓, 2,   TumMeta↑, 1,   β-catenin/ZEB1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 2,   IL6↓, 2,   Inflam↓, 1,   NF-kB↓, 2,   NF-kB↑, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 3,   ChemoSen↑, 2,   eff↑, 1,   MRP1/ABCC1↓, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 2,   Ki-67↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↑, 2,   cardioP↑, 1,   chemoP↑, 1,   hepatoP↑, 3,   neuroP↑, 1,   Risk↑, 1,   toxicity↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,  
Total Targets: 84

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   AntiBio↑, 5,   diuretic↑, 1,   Stress↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 25,   Bil↓, 1,   Catalase↓, 1,   Catalase↑, 10,   GPx↑, 10,   GSH↓, 1,   GSH↑, 17,   GSR↑, 1,   GSTs↑, 1,   HDL↓, 1,   HDL↑, 3,   HO-1↓, 1,   HO-1↑, 6,   Keap1↓, 2,   lipid-P↓, 8,   MDA↓, 17,   MPO↓, 1,   NQO1↑, 3,   NRF2↑, 13,   ROS↓, 24,   ROS↑, 1,   SOD↓, 2,   SOD↑, 15,   SOD1↑, 1,   TAC↑, 3,   TBARS↓, 1,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   ATP↑, 2,   MEK↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 14,   AMPK↓, 1,   AMPK↑, 3,   BUN↓, 1,   cAMP↑, 1,   glucose↓, 1,   glucose↝, 1,   GLUT2↑, 1,   HMG-CoA↓, 1,   LDL↓, 5,   NAD↓, 1,   NADPH↑, 1,   PKM2↓, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 3,   SIRT1↑, 3,   SREBP1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 4,   BAX↓, 3,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp1↓, 1,   Casp3↓, 4,   Casp9↓, 2,   Cyt‑c↓, 2,   Fas↓, 1,   GADD34↓, 1,   HGF/c-Met↑, 1,   iNOS↓, 5,   MAPK↓, 2,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

TRPV3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   other↑, 2,   other↝, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   CHOP/DDIT3↑, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   P53↓, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑ERK↑, 1,   GSK‐3β↓, 1,   miR-34a↓, 1,   mTOR↓, 1,   PI3K↓, 1,   STAT3↓, 1,   p‑STAT3↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 4,   Ca+2↑, 1,   COL3A1↓, 1,   MMP9↓, 1,   MMP9↑, 1,   MUC1↑, 1,   SMAD3↓, 1,   TGF-β↓, 1,   TGF-β1↓, 1,   TXNIP↓, 1,   Vim↓, 1,   ZO-1↑, 1,   α-SMA↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 2,   Hif1a↓, 2,   NO↓, 5,   TXA2↓, 1,   VEGF↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 4,   IBI↑, 1,   OCLN↓, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 2,   COX2↓, 5,   CRP↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 3,   IL10↓, 2,   IL10↑, 1,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 9,   IL2↓, 1,   IL6↓, 8,   IL6↑, 1,   Imm↓, 1,   Imm↑, 3,   Inflam↓, 27,   Inflam↑, 1,   JAK↓, 1,   p‑JAK2↓, 1,   MyD88↓, 2,   NF-kB↓, 12,   p65↓, 1,   PGE2↓, 1,   TLR4↓, 5,   TNF-α↓, 11,   TNF-α↑, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,   NLRP3↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 4,   BioAv↝, 2,   BioEnh↑, 1,   Dose↑, 1,   Dose↝, 17,   eff↑, 5,   eff↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 14,   ALP↓, 3,   AST↓, 14,   Bil↓, 1,   BloodF↑, 1,   BP↓, 1,   creat↓, 1,   CRP↓, 1,   GutMicro↑, 6,   IL6↓, 8,   IL6↑, 1,   TG/TAG↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiDiabetic↑, 10,   AntiTum↑, 2,   cardioP↑, 10,   chemoPv↑, 1,   cognitive↑, 3,   hepatoP↑, 48,   memory↑, 2,   neuroP↑, 13,   Obesity↓, 4,   OS↑, 1,   Pain↓, 2,   RenoP↑, 6,   toxicity↓, 5,   toxicity↝, 4,   toxicity∅, 1,   Wound Healing↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 6,   Diar↓, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Phen↑, 1,   QC↑, 1,  
Total Targets: 200

Scientific Paper Hit Count for: hepatoP, L,hepatoprotective
8 Thymoquinone
5 Baicalein
4 Silver-NanoParticles
4 Emodin
4 Ferulic acid
3 Resveratrol
3 Crocetin
2 Silymarin (Milk Thistle) silibinin
2 Carvacrol
2 Chlorogenic acid
2 Vitamin C (Ascorbic Acid)
2 methotrexate
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Selenium NanoParticles
2 Shikonin
1 1,8-Cineole
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Curcumin
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Apigenin (mainly Parsley)
1 Ashwagandha(Withaferin A)
1 Baicalin
1 doxorubicin
1 Boron
1 Selenium
1 α-Bisabolol / Chamomile oil
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorophyllin
1 Choline
1 Cichoric acid / Chicoric acid
1 Carvone
1 Date Fruit Extract
1 diet Fermented Foods
1 Ginkgo biloba-EGb 761
1 Eugenol
1 Sesame seeds and Oil
1 Fennel Oil/Foeniculum vulgare
1 Ginger/6-Shogaol/Gingerol
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Linalool
1 Luteolin
1 nicotinamide adenine dinucleotide
1 Neem
1 Nimbolide
1 Propolis -bee glue
1 Quercetin
1 Rosmarinic acid
1 Sulforaphane (mainly Broccoli)
1 Radiotherapy/Radiation
1 Cisplatin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1179  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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