GH Cancer Research Results

GH, Growth Hormone: Click to Expand ⟱
Source:
Type:
GH is secreted by the pituitary and also produced locally by many tumors (autocrine/paracrine GH).
Growth hormone signaling is pro-oncogenic when chronically elevated or locally produced by tumors, acting mainly through:
-IGF-1 → PI3K–AKT–mTOR
-JAK2–STAT5
-Angiogenesis and EMT support
It functions as a metabolic growth amplifier, especially in insulin-resistant and obesity-linked cancers.

Interventions (context-dependent):
-Caloric restriction / fasting
-Insulin sensitivity improvement
-mTOR / IGF-1R pathway inhibition (oncology settings)


Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
5231- Ex,    Regular Physical Exercise Increase Of Growth Hormone (GH) And Insulin-Like Growth Factor-1 (IGF-1) Activity in Elderly Improve the Aging Process and Quality of Life: A Mini Review
- Human, Nor, NA
*GH↑, *IGF-1↑,
7069- GABA,    United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA)
- Review, Nor, NA
*toxicity↓, *BP↓, *AntiDiabetic↑, *AntiCan↑, *antiOx↑, *Inflam↓, *AntiBio↑, *other↝, *cognitive↑, *GH↑, *Sleep↑, *BioAv↑, *Half-Life↝, *BBB↓, *eff↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GH↑, 2,   IGF-1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   cognitive↑, 1,   Sleep↑, 1,   toxicity↓, 1,  
Total Targets: 16

Scientific Paper Hit Count for: GH, Growth Hormone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1426  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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