CB2 / CNR2 Cancer Research Results

CB2 / CNR2, Cannabinoid receptor type 2: Click to Expand ⟱
Source:
Type:

CB2 / CNR2 : Druggable immune-enriched cannabinoid receptor involved in microglia, inflammation, immune-cell signaling, pain, neuroprotection, and tumor-immune regulation.

-when a product binds selectively to the CB2 receptors(modulates up) and not the CB1 receptor, it non-psychoactive and therapeutically appealing.
-activation of the CB2 receptor can suppress pro-inflammatory cytokines production, helping to create an anti-tumor immune environment

Field Suggested Entry
Target CB2 / CNR2
Full Name Cannabinoid receptor type 2
Target Class G-protein-coupled receptor; Gi/o-coupled cannabinoid receptor
Primary Biology Immune modulation, microglial activation, inflammatory signaling, cytokine regulation, leukocyte behavior, pain/inflammation signaling
Cancer Relevance Medium and context-dependent: may suppress inflammation or tumorigenesis in some settings, but may also support immune suppression or tumor progression depending on tumor type and immune context
AD Relevance Medium-high: microglial CB2 activation is a promising neuroinflammation strategy, with encouraging preclinical evidence in AD models but limited clinical validation
Therapeutic Direction Usually selective CB2 agonism/modulation for neuroinflammation and inflammatory disease; cancer direction is tumor-context-dependent
Key Product Links β-caryophyllene, PEA, CBD/cannabinoid-system modulators, endocannabinoids, omega-3-derived lipid mediators


Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
6519- BCP,    beta-Caryophyllene: A Sesquiterpene with Countless Biological Properties
- Review, Nor, NA
*CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2↓, *PPARα↑, *PPARγ↑, *BioEnh↑,
6516- BCP,    β-Caryophyllene, a CB2-Receptor-Selective Phytocannabinoid, Suppresses Mechanical Allodynia in a Mouse Model of Antiretroviral-Induced Neuropathic Pain
- in-vivo, Nor, NA
*NP/CIPN↓, *Inflam↓, *CB2 / CNR2↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

CB2 / CNR2↑, 2,  

Core Metabolism/Glycolysis ⓘ

PPARα↑, 1,   PPARγ↑, 1,  

Cell Death ⓘ

iNOS↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 2,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioEnh↑, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

NP/CIPN↓, 1,  
Total Targets: 14

Scientific Paper Hit Count for: CB2 / CNR2, Cannabinoid receptor type 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1500  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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