p62 Cancer Research Results

p62, p62/sequestosome 1 (SQSTM1): Click to Expand ⟱
Source:
Type:
A protein that plays a crucial role in various cellular processes, including autophagy, cell signaling, and protein degradation.
p62 is a scaffold protein that interacts with various signaling molecules, including kinases, phosphatases, and ubiquitin ligases. It is also a substrate of autophagy, a process by which cells recycle damaged or dysfunctional organelles and proteins.
p62 is overexpressed in various types of cancer, including breast, lung, colon, and liver cancer.
Its overexpression has been associated with poor prognosis and reduced survival in some cancers.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
2287- AgNPs,    Silver nanoparticles induce endothelial cytotoxicity through ROS-mediated mitochondria-lysosome damage and autophagy perturbation: The protective role of N-acetylcysteine
- in-vitro, Nor, HUVECs
*TumCP↓, *ROS↑, *eff↓, *MDA↑, *GSH↓, *MMP↓, *ATP↓, *LC3II↑, *p62↑, *Bcl-2↓, *BAX↑, *Casp3↑,
1563- Api,  MET,    Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells
- in-vitro, Nor, HDFa - in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP - in-vivo, NA, NA
selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,
7041- GA,    Gallic acid suppresses the progression of clear cell renal cell carcinoma through inducing autophagy via the PI3K/Akt/Atg16L1 signaling pathway
- vitro+vivo, RCC, 786-O - in-vitro, RCC, ACHN - in-vitro, Nor, HK-2
selectivity↑, TumCP↓, TumCMig↓, TumCI↓, TumCCA↑, TumVol↓, TumW↓, Ki-67↓, MMP9↓, TumAuto↑, LC3B-II↓, Beclin-1↓, p62↑,
1709- Lyco,    Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation
- in-vitro, Nor, JB6
*antiOx↑, *NRF2↑, *GSH/GSSG↓, *Catalase↝, *GR↝, *SOD↝, *GPx↝, *GSH↑, *Keap1↓, *p62↑,
1483- SFN,    Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment
- in-vitro, OS, 143B - in-vitro, Nor, HEK293 - in-vivo, OS, NA
AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   i-Iron↑, 1,   lipid-P↑, 1,   MDA↑, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   BIM↑, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   Ferroptosis↑, 1,   MLKL↑, 1,   p‑MLKL↓, 1,   Necroptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   LC3B↑, 2,   LC3B-II↓, 1,   p62↑, 3,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   p‑P53↑, 1,   p‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↑, 1,  

Migration(tgid=13) ⓘ

Ki-67↓, 2,   MMP9↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Barriers & Transport(tgid=15) ⓘ

SLC12A5↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose∅, 1,   eff↓, 3,   eff↑, 1,   selectivity↓, 1,   selectivity↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   TumVol↓, 2,   TumW↓, 3,  
Total Targets: 49

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↝, 1,   GPx↝, 1,   GSH↓, 1,   GSH↑, 1,   GSH/GSSG↓, 1,   Keap1↓, 1,   MDA↑, 1,   NRF2↑, 1,   ROS↑, 1,   SOD↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   MMP↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↑, 1,   p62↑, 2,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity∅, 1,   Weight∅, 1,  
Total Targets: 23

Scientific Paper Hit Count for: p62, p62/sequestosome 1 (SQSTM1)
1 Silver-NanoParticles
1 Apigenin (mainly Parsley)
1 Metformin
1 Gallic acid
1 Lycopene
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:602  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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