Cancer Database Query Results

Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
5345- ,    Effect of ajoene, the major antiplatelet compound from garlic, on platelet thrombus formation
- in-vitro, Nor, NA
*AntiAg↑,
4113- ,    Post-exposure Effects of PEMF on ROS levels in H2O2-treated Glioblastoma Cell Line
- in-vitro, Nor, U87MG
*ROS↓, *SOD2↑,
4442- ,    Anticancer and Hepatoprotective Role of Selenium Nanoparticles against
- in-vivo, Liver, HepG2 - NA, Nor, NA
*hepatoP↑, AntiCan↑,
2326- 2DG,    Caloric Restriction Mimetic 2-Deoxyglucose Alleviated Inflammatory Lung Injury via Suppressing Nuclear Pyruvate Kinase M2–Signal Transducer and Activator of Transcription 3 Pathway
- in-vivo, Nor, NA
PKM2↓, Inflam↓, TNF-α↓, IL6↓, OS↑,
5272- 3BP,    The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
Glycolysis↓, ROS↑, GPx↓, eff↓, OXPHOS↓, HK2↓, ATP↓, ROS↑, ER Stress↑, BioAv↓, Cyt‑c↑, eff↑,
3538- 5-HTP,    Oral Administration of 5-Hydroxytryptophan Restores Gut Microbiota Dysbiosis in a Mouse Model of Depression
- in-vivo, Nor, NA
*GutMicro↑, *BBB↑, *5HT↑, *Weight↓,
5308- 5-HTP,    The Relationship Between Serotonin and 5-HTP
- Review, Nor, NA
*5HT↑,
5302- 5-HTP,    Hippocampal ischaemia from accidental 5-Hydroxytryptophan (5-HTP) overdose case report
- Case Report, Nor, NA
*toxicity↑, *Dose↑,
5310- 5-HTP,    5-Hydroxytryptophan toxicity successfully treated by haemodialysis in a dog
- Case Report, Nor, NA
*Dose↑, *toxicity↝,
5295- 5-HTP,    Safety of 5-hydroxy-L-tryptophan
- in-vivo, Nor, NA
*5HT↑, *toxicity↝, *toxicity↓,
5294- 5-HTP,    Eosinophilia-myalgia syndrome case-associated contaminants in commercially available 5-hydroxytryptophan
- in-vivo, Nor, NA
*toxicity↑,
5291- 5-HTP,    Kinetics of l-5-hydroxytryptophan in healthy subjects
- in-vivo, Nor, NA
*Half-Life↝, *BioAv↑,
5290- 5-HTP,    Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers
- in-vivo, Nor, NA
*5HT↑,
5300- 5-HTP,    The Serotonin Syndrome: From Molecular Mechanisms to Clinical Practice
- Review, Nor, NA
*toxicity↝,
5307- 5-HTP,    5-Hydroxytryptophan toxicosis in dogs: 1989-1999
- Case Report, Nor, NA
*toxicity↝, *5HT↑, *Dose↝,
5305- 5-HTP,    An Investigation of the Cause of the Eosinophilia–Myalgia Syndrome Associated with Tryptophan Use
- Review, Nor, NA
*toxicity↝, *toxicity↝,
5313- acet,    Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?
- Review, Nor, NA
*COX2↓,
5461- AF,    Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
Paraptosis↑, ER Stress↑, TrxR↓, selectivity↑, toxicity↝, ROS↑, mt-TrxR1↓, mt-TrxR2↓,
5457- AF,    Clinical pharmacokinetics of oral and injectable gold compounds
- Human, Nor, NA
*BioAv↝, *Dose↝, *Half-Life↑, *BioAv↝, *other↝,
5456- AF,    Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent
- Trial, Nor, NA
*Dose?, *Half-Life↝, *Dose↑, *toxicity↝, *Bacteria↓, *Dose↑,
1097- AG,    Astragalus Inhibits Epithelial-to-Mesenchymal Transition of Peritoneal Mesothelial Cells by Down-Regulating β-Catenin
- in-vitro, Nor, HMrSV5 - in-vivo, NA, NA
*EMT↓, *E-cadherin↑, *α-SMA↓, *Vim↓, *β-catenin/ZEB1↓, *Smad7↑,
5442- AG,  Ome,    Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats
- in-vivo, Nor, NA
*other?, *P-gp↑, *CYP3A4↑,
5443- AG,    Pharmacokinetics and tolerance of toal astragalosides after intravenous infusion of astragalosides injection in healthy Chinese volunteers
- Human, Nor, NA
*Dose↝, Half-Life↝, *toxicity↓,
5236- AgNPs,    Adaptive regulations of Nrf2 alleviates silver nanoparticles-induced oxidative stress-related liver cells injury
- in-vitro, Liver, HepG2 - in-vitro, Nor, L02
tumCV↓, ROS↑, *ROS↑, DNAdam↑, *DNAdam↑, eff↓, selectivity↑,
5239- AgNPs,    NOX4- and Nrf2-mediated oxidative stress induced by silver nanoparticles in vascular endothelial cells
- in-vitro, Nor, HUVECs
*ROS↑, *Apoptosis↑, *NRF2↝,
1406- AgNPs,    The antioxidant effects of silver, gold, and zinc oxide nanoparticles on male mice in in vivo condition
- in-vivo, Nor, NA
*ROS↓, *GPx↑, *Catalase↑, *ROS↑,
1909- AgNPs,    The Antibacterial Drug Candidate SBC3 is a Potent Inhibitor of Bacterial Thioredoxin Reductase
- in-vivo, Nor, NA
TrxR↓,
1905- AgNPs,    Evaluation of the effect of silver and silver nanoparticles on the function of selenoproteins using an in-vitro model of the fish intestine: The cell line RTgutGC
- in-vivo, Nor, NA
*TrxR↓, *ROS∅, GPx↑,
4402- AgNPs,    Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors
- in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCD↑, selectivity↑, *toxicity↝, Dose↝, OS↑,
4400- AgNPs,  Rad,    Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, BC, MDA-MB-231
ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, eff↑,
4393- AgNPs,    Nanotoxic Effects of Silver Nanoparticles on Normal HEK-293 Cells in Comparison to Cancerous HeLa Cell Line
- in-vitro, Cerv, HeLa - in-vitro, Nor, HEK293
selectivity↓,
4382- AgNPs,    Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism
- in-vitro, Nor, RAW264.7
*GSH↓, *NO↑, *TNF-α↑, *MMP3↑, *MMP11↑,
4411- AgNPs,    Eco-friendly synthesis of silver nanoparticles using Anemone coronaria bulb extract and their potent anticancer and antibacterial activities
- in-vitro, Lung, A549 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, PC3 - in-vitro, Nor, HEK293
AntiCan↑, selectivity↑, Apoptosis↑, TumCCA↑, Bacteria↓, tumCV↓, selectivity↑, Apoptosis↑, TumCCA↑,
4431- AgNPs,  doxoR,    Oxidative Stress-Induced Silver Nano-Carriers for Chemotherapy
- in-vitro, BC, 4T1 - in-vivo, BC, 4T1 - in-vitro, Nor, 3T3
AntiCan↑, ROS↑, TumVol↓, EPR↑, selectivity↑, ChemoSen↑,
4360- AgNPs,    Silver Nanoparticles as Real Topical Bullets for Wound Healing
- Study, Nor, NA
*other↝, *toxicity↓, *eff↑, *eff↑, *Inflam↓, *IL6↓, *TGF-β↑, *MMP9↓, *eff↑,
4430- AgNPs,    Evaluation of the Genotoxic and Oxidative Damage Potential of Silver Nanoparticles in Human NCM460 and HCT116 Cells
- in-vitro, Colon, HCT116 - in-vitro, Nor, NCM460
*Bacteria↓, ROS↑, p‑p38↑, BAX↑, Bcl-2↓, BAX↑, P21↑, TumCD↑, toxicity↝,
4433- AgNPs,    Advancements in metal and metal oxide nanoparticles for targeted cancer therapy and imaging: Mechanisms, applications, and safety concerns
- in-vitro, Liver, HepG2 - in-vitro, Nor, L02
selectivity↑, selectivity↓, mt-ROS↑,
4434- AgNPs,  SSE,    Sodium Selenite Ameliorates Silver Nanoparticles Induced Vascular Endothelial Cytotoxic Injury by Antioxidative Properties and Suppressing Inflammation Through Activating the Nrf2 Signaling Pathway
- vitro+vivo, Nor, NA
*ROS↓, *Inflam↓, *NLRP3↓, *NF-kB↓, *NRF2↑, *HO-1↑, *toxicity↓,
4447- AgNPs,    Anti-inflammatory action of silver nanoparticles in vivo: systematic review and meta-analysis
- Review, Nor, NA
*Inflam↓, *COX2↓, *ROS↓, *Dose↝, *eff↑, *toxicity↓, *IL4↑, *IL5↑, *IL10↑, *IL1↓, *IL6↓, *TNF-α↓, *NF-kB↓, *MDA↓, *GSH↑,
4376- AgNPs,    Interaction of multi-functional silver nanoparticles with living cells
- in-vitro, Nor, L929 - in-vitro, Lung, A549
eff↑, selectivity↑,
4369- AgNPs,    Silver nanoparticles induce p53-mediated apoptosis in human bronchial epithelial (BEAS-2B) cells
- in-vitro, Nor, BEAS-2B
*ROS↑,
4368- AgNPs,    Silver nanoparticles crossing through and distribution in the blood-brain barrier in vitro
- NA, Nor, NA
*BBB↑,
4367- AgNPs,    Effects of Prolonged Silver Nanoparticle Exposure on the Contextual Cognition and Behavior of Mammals
- in-vivo, Nor, NA
*other↝,
4366- AgNPs,    Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles
- in-vivo, Nor, NA
*GutMicro↝,
4561- AgNPs,  VitC,    Cellular Effects Nanosilver on Cancer and Non-cancer Cells: Potential Environmental and Human Health Impacts
- in-vitro, CRC, HCT116 - in-vitro, Nor, HEK293
NRF2↑, TumCCA↑, ROS↑, selectivity↑, *AntiViral↑, *toxicity↝, ETC↓, MMP↓, DNAdam↑, Apoptosis↑, lipid-P↑, other↝, UPR↑, *GRP78/BiP↑, *p‑PERK↑, *cl‑eIF2α↑, *CHOP↑, *JNK↑, Hif1a↓, AntiCan↑, *toxicity↓, eff↑,
4553- AgNPs,    Cytotoxicity induced by engineered silver nanocrystallites is dependent on surface coatings and cell types
- in-vitro, Nor, RAW264.7
*Wound Healing↑, *eff↝, *toxicity↝,
4539- AgNPs,  VitC,  Citrate,    Investigating the Anti-cancer Potential of Silver Nanoparticles Synthesized by Chemical Reduction of AgNO3 Using Trisodium Citrate and Ascorbic Acid
- in-vitro, Nor, L929 - in-vitro, Ovarian, SKOV3
AntiCan↑,
4550- AgNPs,    The Effect of Charge at the Surface of Silver Nanoparticles on Antimicrobial Activity against Gram-Positive and Gram-Negative Bacteria: A Preliminary Study
- Study, Nor, NA
*Bacteria↓,
4544- AgNPs,  VitC,    Current Research on Silver Nanoparticles: Synthesis, Characterization, and Applications
- Review, Nor, NA
*Bacteria↓, *eff↑,
4543- AgNPs,    Biogenic synthesis of silver nanoparticles using Zaleya pentandra and investigation of their biological activities
- Study, Nor, NA
*Bacteria↓,

Showing Research Papers: 1 to 50 of 834
Page 1 of 17 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 834

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GPx↓, 1,   GPx↑, 1,   lipid-P↑, 1,   NRF2↑, 1,   OXPHOS↓, 1,   ROS↑, 8,   mt-ROS↑, 1,   TrxR↓, 2,   mt-TrxR1↓, 1,   mt-TrxR2↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   ETC↓, 1,   MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,   HK2↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Apoptosis↑, 3,   BAX↑, 2,   Bcl-2↓, 1,   Cyt‑c↑, 1,   p‑p38↑, 1,   Paraptosis↑, 1,   TumCD↑, 2,  

Transcription & Epigenetics ⓘ

other↝, 2,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 2,   UPR↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 3,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Angiogenesis & Vasculature ⓘ

EPR↑, 1,   Hif1a↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   ChemoSen↑, 1,   Dose↓, 1,   Dose↝, 2,   eff↓, 3,   eff↑, 5,   Half-Life↝, 1,   RadioS↑, 1,   selectivity↓, 2,   selectivity↑, 11,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 5,   OS↑, 2,   toxicity↝, 2,   TumVol↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 53

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GPx↑, 1,   GSH↓, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   NRF2↑, 1,   NRF2↝, 1,   ROS↓, 4,   ROS↑, 4,   ROS∅, 1,   SOD2↑, 1,   TrxR↓, 1,  

Core Metabolism/Glycolysis ⓘ

CYP3A4↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   JNK↑, 1,  

Transcription & Epigenetics ⓘ

other?, 1,   other↝, 3,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   cl‑eIF2α↑, 1,   GRP78/BiP↑, 1,   p‑PERK↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,  

Migration ⓘ

AntiAg↑, 1,   E-cadherin↑, 1,   MMP11↑, 1,   MMP3↑, 1,   MMP9↓, 1,   Smad7↑, 1,   TGF-β↑, 1,   Vim↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↑, 1,  

Barriers & Transport ⓘ

BBB↑, 2,   P-gp↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL1↓, 1,   IL10↑, 1,   IL4↑, 1,   IL5↑, 1,   IL6↓, 2,   Inflam↓, 3,   NF-kB↓, 2,   TNF-α↓, 1,   TNF-α↑, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 5,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 2,   Dose?, 1,   Dose↑, 4,   Dose↝, 4,   eff↑, 5,   eff↝, 1,   Half-Life↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,   GutMicro↝, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

hepatoP↑, 1,   toxicity↓, 6,   toxicity↑, 2,   toxicity↝, 10,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

AntiViral↑, 1,   Bacteria↓, 5,  
Total Targets: 69

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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