Bcl-2 Cancer Research Results
Bcl-2, B-cell CLL/lymphoma 2: Click to Expand ⟱
| Source: HalifaxProj (inhibit)
CGL-Driver Genes |
| Type: Antiapoptotic
Oncogene |
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL, the pro-apoptotic proteins represented by BAX and Bak, and the pro-apoptotic BH3-only proteins represented by BAD and BID.
Since the expression of Bcl-2 protein in tumor cells is much higher than that in normal cells, inhibitors targeting it have little effect on normal cells.
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Chon, Chondrosarcoma: Click to Expand ⟱
Chondrosarcoma is a soft tissue sarcoma with a poor prognosis that is unresponsive to conventional chemotherapy. Chondrosarcoma is a member of a category of tumors of bone and soft tissue known as sarcomas. ~30% of bone sarcomas are chondrosarcomas. Resistant to chemotherapy and radiotherapy.
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Scientific Papers found: Click to Expand⟱
| - |
in-vitro, |
Chon, |
SW1353 |
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in-vitro, |
Chon, |
CRL-7891 |
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HH↓, Gli1↓, PTCH1↓, Bcl-2↓, BAX↑, TumCG↓,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Cell Death ⓘ
BAX↑, 1, Bcl-2↓, 1,
Proliferation, Differentiation & Cell State ⓘ
Gli1↓, 1, HH↓, 1, PTCH1↓, 1, TumCG↓, 1,
Total Targets: 6
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: Bcl-2, B-cell CLL/lymphoma 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:5 Cells:% prod#:% Target#:27 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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