Cancer Database Query Results

EC, Endometrial Cancer: Click to Expand ⟱
Endometrial cancer (EC) is the most common gynecological cancer, and one of the most important causes of cancer-related deaths in women worldwide.
Scientific Papers found: Click to Expand⟱
2632- Api,    Apigenin inhibits migration and induces apoptosis of human endometrial carcinoma Ishikawa cells via PI3K-AKT-GSK-3β pathway and endoplasmic reticulum stress
- in-vitro, EC, NA
TumCP↓, TumCCA↑, Apoptosis↑, Bcl-2↓, BAX↑, Bak↑, Casp↑, ER Stress↑, Ca+2↑, ATF4↑, CHOP/DDIT3↑, ROS↑, MMP↓, TumCMig↓, TumCI↓, eff↑, P53↑, P21↑, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-xL↓,
2633- Api,    Apigenin induces ROS-dependent apoptosis and ER stress in human endometriosis cells
- in-vitro, EC, NA
TumCP↓, TumCCA↑, MMP↓, Ca+2↑, BAX↑, Cyt‑c↑, ROS↑, lipid-P↑, ER Stress↑, UPR↑, p‑ERK↓, ERK↓, JNK↑,
1177- Ash,    Withaferin A downregulates COX-2/NF-κB signaling and modulates MMP-2/9 in experimental endometriosis
- in-vivo, EC, NA
TumVol↓, MMP2↓, MMP9↓, NF-kB↓, COX2↓, NO↓, IL1β↓, IL6↓,
1173- Ash,    Withaferin A inhibits proliferation of human endometrial cancer cells via transforming growth factor-β (TGF-β) signalling
- in-vitro, EC, K1 - in-vitro, Nor, THESCs
TumCP↓, *toxicity↓, Apoptosis↑, TumCCA↑, TumCMig↓, TumCI↓, p‑SMAD2↓, TGF-β↓, *toxicity↓,
1612- EA,    Negative Effect of Ellagic Acid on Cytosolic pH Regulation and Glycolytic Flux in Human Endometrial Cancer Cell
- in-vitro, EC, NA
NHE1↓, i-pH↓, ROS↓, GlucoseCon↓, NHE1↓, Glycolysis↓,
1303- EGCG,    (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation
- in-vitro, EC, NA
TumCP↓, ER-α36↓, cycD1/CCND1↓, ERK↑, Jun↓, BAX↑, Bcl-2↓, cl‑Casp3↑, ROS↑, p38↑,
7012- Fuc,    Fucoidan: A promising natural therapeutic agent for protecting human kidney health
- Review, EC, NA
*RenoP↑, *Inflam↓, *antiOx↑, *ROS↓, *BloodF↑, *diuretic↑, *BioAv↓, *BioAv↑, *MAPK↓, *ERK↑, *NLRP3↓, *NRF2↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *lipid-P↓, *DNAdam↓, *Fibrosis↓, *JAK2↓, *STAT3↓, *uricA↓, *COL1↓, *α-SMA↓, *SIRT1↑, *HO-1↑, *GLP-1R↑, *HMGB1↓, *RAGE↓, *NF-kB↓, *TGF-β1↓, *PI3K↓, *Akt↓, *GutMicro↑, *SCFAs↑, *Buty↑, *IBI↑, *TJ↑, *Dose↝,
804- GAR,    Garcinol inhibits the proliferation of endometrial cancer cells by inducing cell cycle arrest
- in-vitro, EC, HEC1B - in-vitro, EC, ISH
TumCP↓, TumCCA↑, P53↑, P21↑, CDK2↓, CDK4↓, cycD1/CCND1↓, CycB/CCNB1↓, p‑cJun↑,
2054- PB,    Sodium butyrate induces ferroptosis in endometrial cancer cells via the RBM3/SLC7A11 axis
- in-vitro, EC, ISH - in-vitro, EC, HEC1B
Ferroptosis↑, xCT↓, RBM3↑, HDAC↓, ROS↑,
4686- QC,    Quercetin suppresses endometrial cancer stem cells via ERα-mediated inhibition of STAT3 signaling
- in-vitro, EC, EMN8 - in-vitro, EC, EMN21
CSCs↓, ALDH1A1↓, cMyc↓, Nanog↓, OCT4↓, STAT3↓, JAK2↓, STAT3↓, eff↑,
1703- Se,    An Assessment of Serum Selenium Concentration in Women with Endometrial Cancer
- Study, EC, NA
Risk↓, selm↝,

Showing Research Papers: 1 to 11 of 11

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   lipid-P↑, 1,   ROS↓, 1,   ROS↑, 4,   xCT↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

selm↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   Bak↑, 1,   BAX↑, 3,   Bcl-2↓, 2,   Bcl-xL↓, 1,   Casp↑, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 2,   Ferroptosis↑, 1,   JNK↑, 1,   p38↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cJun↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 2,   UPR↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   P21↑, 2,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   CSCs↓, 1,   ERK↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   HDAC↓, 1,   Jun↓, 1,   Nanog↓, 1,   OCT4↓, 1,   STAT3↓, 2,  

Migration(tgid=13) ⓘ

Ca+2↑, 2,   ER-α36↓, 1,   MMP2↓, 1,   MMP9↓, 1,   p‑SMAD2↓, 1,   TGF-β↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 5,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↑, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

NHE1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   IL1β↓, 1,   IL6↓, 1,   JAK2↓, 1,   NF-kB↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

i-pH↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,   RBM3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Risk↓, 1,   TumVol↓, 1,  
Total Targets: 67

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Buty↑, 1,   diuretic↑, 1,   GLP-1R↑, 1,   SCFAs↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,   uricA↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   MAPK↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   PI3K↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

COL1↓, 1,   Fibrosis↓, 1,   RAGE↓, 1,   TGF-β1↓, 1,   TJ↑, 1,   α-SMA↓, 1,  

Barriers & Transport(tgid=15) ⓘ

IBI↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,   Inflam↓, 1,   JAK2↓, 1,   NF-kB↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   GutMicro↑, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

RenoP↑, 1,   toxicity↓, 2,  
Total Targets: 41

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:52  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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