GlutMet Cancer Research Results

GlutMet, Glutamine metabolism: Click to Expand ⟱

Source:

Type:

Glutamine metabolism plays a significant role in cancer biology, as many cancer cells exhibit altered metabolic pathways to support their rapid growth and proliferation.
Glutamine is a non-essential amino acid that serves as a vital nutrient for many cells, including cancer cells. It is involved in various metabolic processes, including protein synthesis, nucleotide synthesis, and energy production.
Warburg Effect: Cancer cells often rely on aerobic glycolysis (the Warburg effect) for energy production, even in the presence of oxygen. Glutamine metabolism can complement this process by providing intermediates for the tricarboxylic acid (TCA) cycle, which is crucial for energy production and biosynthesis.
Inhibitors of glutaminase (an enzyme that converts glutamine to glutamate) and other metabolic pathways are being explored in preclinical and clinical settings.

Key Enzymes in Glutamine Metabolism
Glutaminase (GLS)
Glutamate Dehydrogenase (GLUD)
Glutamine Synthetase (GS)
Asparagine Synthetase (ASNS)
Aminotransferases (e.g., GPT, GOT)

The expression of enzymes involved in glutamine metabolism is often elevated in various cancers and is generally associated with poorer prognosis.

UEC, Uterine Endometrial Cancer: Click to Expand ⟱

Uterine Endometrial Cancer

Scientific Papers found: Click to Expand⟱

975-

Est,

Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolism

vitro+vivo,

UEC,

GLS↑, cMyc↑, GlutMet↑, tumCV↑, TumAuto↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

cMyc↑, 1, GLS↑, 1, GlutMet↑, 1,

Transcription & Epigenetics ⓘ

tumCV↑, 1,

Autophagy & Lysosomes ⓘ

TumAuto↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: GlutMet, Glutamine metabolism

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells