CYP24A1 Cancer Research Results

CYP24A1, 24-hydroxylase: Click to Expand ⟱
Source:
Type:
CYP24A1 (24-hydroxylase) is the main enzyme that inactivates vitamin D hormones, especially 1,25-dihydroxyvitamin D (calcitriol), by hydroxylating it toward water-soluble metabolites. In cancer biology, that matters because calcitriol signaling through the vitamin D receptor (VDR) can push cells toward differentiation, cell-cycle arrest, and sometimes apoptosis, and can dampen pro-inflammatory signaling. So, when CYP24A1 is high, tumors can effectively “turn off” local vitamin D anti-tumor signaling.
Many studies report CYP24A1 overexpression in subsets of cancers (commonly discussed in colon/colorectal, breast, lung, prostate, ovarian, thyroid, melanoma, among others).
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
5381- ART/DHA,    Artemisitene triggers calcium-dependent ferroptosis by disrupting the LSH-EWSR1 interaction in colorectal cancer
- in-vitro, CRC, HCT116 - in-vitro, Nor, NCM460 - in-vitro, CRC, HT29 - in-vitro, CRC, HCT8
Ferroptosis↑, CYP24A1↓, Ca+2↑, SCD1↓, FAO↑, lipid-P↑, eff↑, selectivity↑, other?,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   lipid-P↑, 1,  

Core Metabolism/Glycolysis ⓘ

FAO↑, 1,   SCD1↓, 1,  

Cell Death ⓘ

Ferroptosis↑, 1,  

Transcription & Epigenetics ⓘ

other?, 1,  

Migration ⓘ

Ca+2↑, 1,  

Hormonal & Nuclear Receptors ⓘ

CYP24A1↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   selectivity↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CYP24A1, 24-hydroxylase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:1448  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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