LIFR/CD118 Cancer Research Results

LIFR/CD118, Leukemia Inhibitory Factor Receptor: Click to Expand ⟱
Source:
Type:

LIFR - Leukemia Inhibitory Factor Receptor

Abbreviation: LIFR, CD118

Type: Cytokine receptor / gp130-family receptor

Function: Cell-surface cytokine receptor that forms signaling complexes with gp130 (IL6ST) and responds to leukemia inhibitory factor (LIF) and related cytokines. LIFR signaling activates pathways including JAK/STAT3, MAPK/ERK, PI3K/AKT, and mTOR and regulates cell survival, differentiation, proliferation, stemness, inflammation, and tissue remodeling.

Cancer: ↕ Context-dependent. Increased LIF/LIFR signaling is oncogenic in many solid tumors and can promote proliferation, survival, cancer stem-cell properties, invasion, metastasis, immune suppression, and resistance to therapy. However, LIFR can function as a metastasis suppressor in selected cancers, making its effect dependent on tumor type and signaling context.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
7445- CYN,    Cynaropicrin Shows Antitumor Progression Potential in Colorectal Cancer Through Mediation of the LIFR/STATs Axis
- vitro+vivo, CRC, RKO - in-vitro, CRC, HCT116 - in-vitro, CRC, DLD1
tumCV↓, STAT↓, LIFR/CD118↓, STAT3↓, STAT4↑, TumCG?, cl‑PARP1↑, Bcl-2↓, BAX↑, STAT3↓, Dose↝, TumVol↓, TumW↓, toxicity↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

LIFR/CD118↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   Bcl-2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT↓, 1,   STAT3↓, 2,   STAT4↑, 1,   TumCG?, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LIFR/CD118, Leukemia Inhibitory Factor Receptor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:1641  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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