MMP Cancer Research Results

MMP, ΔΨm, mitochondrial membrane potential: Click to Expand ⟱
Source:
Type:
Destruction of mitochondrial transmembrane potential, which is widely regarded as one of the earliest events in the process of cell apoptosis.
Mitochondria are organelles within eukaryotic cells that produce adenosine triphosphate (ATP), the main energy molecule used by the cell. For this reason, the mitochondrion is sometimes referred to as “the powerhouse of the cell”.
Mitochondria produce ATP through process of cellular respiration—specifically, aerobic respiration, which requires oxygen. The citric acid cycle, or Krebs cycle, takes place in the mitochondria.
The mitochondrial membrane potential is widely used in assessing mitochondrial function as it relates to the mitochondrial capacity of ATP generation by oxidative phosphorylation. The mitochondrial membrane potential is a reliable indicator of mitochondrial health.
In cancer cells, ΔΨm is often decreased, which can lead to changes in cellular metabolism, increased glycolysis, increased reactive oxygen species (ROS) production, and altered cell death pathways.

The membrane of malignant mitochondria is hyperpolarized (−220 mV) in comparison to their healthy counterparts (−160 mV), which facilitates the penetration of positively charged molecules to the cancer cells mitochondria.
The MMP is a critical indicator of mitochondrial function, directly reflecting the organelle's capacity to generate ATP through oxidative phosphorylation.


CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
4561- AgNPs,  VitC,    Cellular Effects Nanosilver on Cancer and Non-cancer Cells: Potential Environmental and Human Health Impacts
- in-vitro, CRC, HCT116 - in-vitro, Nor, HEK293
NRF2↑, TumCCA↑, ROS↑, selectivity↑, *AntiViral↑, *toxicity↝, ETC↓, MMP↓, DNAdam↑, Apoptosis↑, lipid-P↑, other↝, UPR↑, *GRP78/BiP↑, *p‑PERK↑, *cl‑eIF2α↑, *CHOP↑, *JNK↑, Hif1a↓, AntiCan↑, *toxicity↓, eff↑,
5143- AgNPs,    Thermal Co-reduction engineered silver nanoparticles induce oxidative cell damage in human colon cancer cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis
- in-vitro, CRC, HCT116
ROS↑, lipid-P↑, GSH↓, MMP↓, Casp3↑, Apoptosis↑, TumCCA↑,
2634- Api,    Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells
- in-vitro, CRC, HCT116
TumCG↓, TumCCA↑, MMP↓, ROS↑, Ca+2↑, ER Stress↑, mtDam↑, CHOP↑, DR5↑, cl‑BID↑, BAX↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, Apoptosis↑,
175- Api,    Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT
- vitro+vivo, CRC, SW480 - vitro+vivo, CRC, DLD1 - vitro+vivo, CRC, LS174T
MMP↓, p‑Akt↓, TumCP↓, TumCI↓, NADH↓, HSP90↓, other↑, talin?,
1356- Ash,    Withaferin A induces apoptosis by ROS-dependent mitochondrial dysfunction in human colorectal cancer cells
- in-vitro, CRC, HCT116
ROS↑, TumCCA↑, MMP↓, TumCG↓, Apoptosis↑, JNK↝,
2477- Ba,    Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells
- in-vitro, CRC, T24/HTB-9
TumCG↓, TumCCA↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, p‑Akt↓, Bcl-2↓, BAX↑, Bax:Bcl2↑, 12LOX↓,
5539- BBM,    Berbamine suppresses cell viability and induces apoptosis in colorectal cancer via activating p53-dependent apoptotic signaling pathway
- vitro+vivo, CRC, SW480
tumCV↓, TumCCA↑, MMP↓, P53↑, Casp3↑, Casp9↑, BAX↑, PARP↑, Bcl-2↓, TumVol↑,
2719- BetA,    Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, UMUC3 - in-vitro, Bladder, 5637
TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,
2745- BetA,    Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors
- in-vitro, CRC, RKO - in-vitro, CRC, SW480 - in-vivo, NA, NA
Apoptosis↑, TumCG↓, Sp1/3/4↓, survivin↓, VEGF↓, p65↓, EGFR↓, cycD1/CCND1↓, ROS↑, MMP↓,
2746- BetA,    Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo
- in-vitro, CRC, HCT116 - in-vivo, CRC, NA
TumCG↓, BAX↑, Bcl-2↓, ROS↑, MMP↓, TIMP2↑, TumVol↓,
5707- Brut,    Targeting Redox Homeostasis and Cell Survival Signaling with a Flavonoid-Rich Extract of Bergamot Juice in In Vitro and In Vivo Colorectal Cancer Models
- in-vitro, CRC, HCT116
Risk↓, TumCG↓, Apoptosis↑, TumCCA↑, ROS↑, MMP↓, DNAdam↑, TumMeta↓, TumCP↓,
2047- Buty,    Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells
- in-vitro, CRC, T24/HTB-9 - in-vitro, Nor, SV-HUC-1 - in-vitro, Bladder, 5637 - in-vivo, NA, NA
HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,
1517- CAP,    Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1)
- in-vitro, Bladder, TSGH8301 - in-vitro, CRC, T24/HTB-9
ENOX2↓, TumCCA↑, ERK↓, p‑FAK↓, p‑pax↓, TumCMig↓, EMT↓, SIRT1↓, Dose∅, ROS↑, MMP↓, Bcl-2↓, Bak↑, cl‑PARP↑, Casp3↑, SIRT1↓, ac‑P53↑, BIM↑, p‑RB1↓, cycD1/CCND1↓, Dose∅, β-catenin/ZEB1↓, N-cadherin↓, E-cadherin↑,
2804- CHr,  Rad,    Gamma-Irradiated Chrysin Improves Anticancer Activity in HT-29 Colon Cancer Cells Through Mitochondria-Related Pathway
- in-vitro, CRC, HT29
RadioS↑, ROS↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑,
1885- DCA,    Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW-620 - in-vitro, CRC, HT-29
SMCT1∅, eff↓, eff↑, eff↑, PDKs↓, MMP↓, Glycolysis↓, mitResp↑, ROS↑, eff↑,
3207- EGCG,    EGCG Enhances the Chemosensitivity of Colorectal Cancer to Irinotecan through GRP78-MediatedEndoplasmic Reticulum Stress
- in-vitro, CRC, RKO - in-vitro, CRC, HCT116
GRP78/BiP↑, MMP↓, ER Stress↑, ROS↓, UPR↑,
5223- EMD,    Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways
- in-vitro, CRC, DLD1 - in-vitro, Nor, CCD841
tumCV↓, Apoptosis↑, selectivity↑, Casp↑, Bcl-2↓, MMP↓, TumCD↑, MAPK↓, JNK↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, Diff↓, P53↑, PARP↓,
1321- EMD,    Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: roles of apoptotic cell death and LS1034 tumor xenografts model
- in-vitro, CRC, LS1034 - in-vivo, NA, NA
tumCV↓, TumCCA↑, ROS↑, Ca+2↑, MMP↓, Apoptosis↑, Cyt‑c↑, Casp9↑, Bax:Bcl2↑,
1296- EMD,    Emodin inhibits LOVO colorectal cancer cell proliferation via the regulation of the Bcl-2/Bax ratio and cytochrome c
- in-vitro, CRC, LoVo
BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑,
2852- FIS,    A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms
- Review, CRC, NA
Risk↓, P53↑, MDM2↓, COX2↓, Wnt↓, NF-kB↓, CDK2↓, CDK4↓, p‑RB1↓, cycE/CCNE↓, P21↑, NRF2↓, ROS↑, Casp8↑, Fas↑, TRAIL↑, DR5↑, MMP↓, Cyt‑c↑, selectivity↑, P450↝, GSTs↝, RadioS↑, Inflam↓, β-catenin/ZEB1↓, EGFR↓, TumCCA↑, ChemoSen↑,
841- Gra,    The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach
- in-vitro, CRC, HT-29 - in-vitro, Nor, CCD841
PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,
858- Gra,    Annona muricata leaves induce G₁ cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells
- in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116
TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Casp↑, BAX↑, Bcl-2↓, TumCMig↓, TumCI↓,
4641- HT,    Hydroxytyrosol induced ferroptosis through Nrf2 signaling pathway in colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
Ferroptosis↑, Iron↑, lipid-P↑, ROS↑, GSH↓, MMP↓, GPx4↓, TLR1↑, eff↓, NRF2↓, ROS↑,
2070- PB,    Phenylbutyrate-induced apoptosis is associated with inactivation of NF-kappaB IN HT-29 colon cancer cells
- in-vitro, CRC, HT-29
TumCG↓, Apoptosis↑, MMP↓, Casp3↑, PARP↓, NF-kB↓, eff↑,
4787- QC,    Quercetin: A Phytochemical with Pro-Apoptotic Effects in Colon Cancer Cells
- Review, CRC, NA
Inflam↓, AntiCan↑, Apoptosis↑, MMP↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, NF-kB↓, IL6↓, IL1β↓, *antiOx↑, *lipid-P↓, *ROS↓, MAPK↓, JAK↓, STAT↓, PI3K↓, Akt↓, chemoP↑, ROS⇅, DNAdam↑, ChemoSen↝,
4902- Sal,  OXA,    Salinomycin and oxaliplatin synergistically enhances cytotoxic effect on human colorectal cancer cells in vitro and in vivo
- vitro+vivo, CRC, NA
RadioS↑, ChemoSen↑, TumCP↓, Apoptosis↑, ROS↑, MMP↓, MAPK↑, eff↓, TumCG↓, TumCCA↑,
3297- SIL,  Rad,    Studies on radiation sensitization efficacy by silymarin in colon carcinoma cells
- in-vitro, CRC, HCT15 - in-vitro, CRC, RKO
TumCP↓, RadioS↑, TumCCA↑, DNAdam↓, MMP↓, ROS↓, *radioP↑,
2008- SK,  Cisplatin,    Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
ChemoSen↑, selectivity↑, i-ROS↑, DNAdam↑, MMP↓, TumCCA↑, eff↓, *toxicity↓,
2007- SK,    Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells
- in-vitro, lymphoma, U937 - in-vitro, BC, MCF-7 - in-vitro, BC, SkBr3 - in-vitro, CRC, HCT116 - in-vitro, OS, U2OS - NA, Nor, RPE-1
tumCV↓, selectivity↑, Dose↝, other↑, MMP↓, ROS↑, DNAdam↑, Ca+2↑, Casp9↑, Cyt‑c↑, *toxicity↓,
2231- SK,    Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways
- in-vitro, CRC, SNU-407
Apoptosis↑, ER Stress↑, PERK↑, eIF2α↑, CHOP↑, mt-Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, ERK↑, JNK↑, p38↓,
2230- SK,    Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
TumCG↓, Bcl-2↓, ROS↑, Bcl-xL↓, MMP↓, Casp↑, selectivity↑, cycD1/CCND1↓, TumCCA↑, eff↓,
4723- SSE,    Selenium Induces Ferroptosis in Colorectal Cancer Cells via Direct Interaction with Nrf2 and Gpx4
- in-vitro, CRC, HCT116
TumCP↓, Iron↑, MDA↑, ROS↑, MMP↓, NRF2↓, GPx4↓, Ferroptosis↑,
1067- VitC,    Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer
- in-vivo, CRC, NA
PDK1↓, Hif1a↓, GLUT1↓, ATP↓, MMP↓,

Showing Research Papers: 1 to 33 of 33

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 33

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ENOX2↓, 1,   Ferroptosis↑, 2,   GPx4↓, 2,   GSH↓, 2,   GSTs↝, 1,   Iron↑, 2,   lipid-P↓, 1,   lipid-P↑, 3,   MDA↑, 1,   NADH↓, 1,   NRF2↓, 3,   NRF2↑, 1,   PARK2↑, 1,   ROS↓, 2,   ROS↑, 20,   ROS⇅, 1,   ROS∅, 1,   i-ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   CDC25↓, 1,   ETC↓, 1,   mitResp↑, 1,   MMP↓, 33,   mtDam↑, 2,   PINK1↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   AMPK↑, 1,   Glycolysis↓, 1,   LDH↓, 1,   PDK1↓, 1,   PDKs↓, 1,   SIRT1↓, 2,  

Cell Death ⓘ

Akt↓, 2,   p‑Akt↓, 2,   Apoptosis↑, 14,   Bak↑, 1,   BAX↑, 10,   Bax:Bcl2↑, 2,   Bcl-2↓, 12,   Bcl-xL↓, 2,   cl‑BID↑, 1,   BIM↑, 1,   Casp↑, 3,   Casp3↑, 10,   cl‑Casp3↑, 2,   Casp7↑, 1,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 9,   cl‑Casp9↑, 1,   Cyt‑c↑, 8,   DR5↑, 2,   Fas↑, 1,   Ferroptosis↑, 2,   JNK↓, 1,   JNK↑, 1,   JNK↝, 1,   MAPK↓, 2,   MAPK↑, 1,   MDM2↓, 1,   p38↓, 1,   survivin↓, 1,   TRAIL↑, 1,   TumCD↑, 2,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 2,   other↝, 1,   tumCV↓, 4,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   eIF2α↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 1,   HSP90↓, 1,   PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   p62↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   DNAdam↑, 5,   P53↑, 4,   ac‑P53↑, 1,   PARP↓, 2,   PARP↑, 1,   cl‑PARP↑, 4,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 2,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   P21↑, 1,   p‑RB1↓, 2,   TumCCA↑, 16,  

Proliferation, Differentiation & Cell State ⓘ

BMI1↓, 1,   Diff↓, 1,   EMT↓, 1,   ERK↓, 1,   ERK↑, 1,   HDAC↓, 1,   mTOR↑, 1,   PI3K↓, 2,   STAT↓, 2,   TumCG↓, 11,   Wnt↓, 1,  

Migration ⓘ

Ca+2↑, 3,   mt-Ca+2↑, 1,   E-cadherin↑, 2,   p‑FAK↓, 1,   miR-139-5p↑, 1,   MMP9↓, 1,   N-cadherin↓, 2,   p‑pax↓, 1,   Slug↓, 1,   Snail↓, 2,   talin?, 1,   TIMP2↑, 1,   TumCI?, 1,   TumCI↓, 3,   TumCMig↓, 4,   TumCP↓, 5,   TumMeta↓, 2,   Vim↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 2,   Hif1a↓, 2,   VEGF↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,   SMCT1∅, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 2,   JAK↓, 1,   NF-kB↓, 4,   p65↓, 1,   TLR1↑, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 3,   ChemoSen↝, 1,   Dose↝, 1,   Dose∅, 2,   eff↓, 6,   eff↑, 5,   P450↝, 1,   RadioS↑, 4,   selectivity↑, 8,  

Clinical Biomarkers ⓘ

EGFR↓, 2,   IL6↓, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   chemoP↑, 1,   Risk↓, 2,   TumVol↓, 1,   TumVol↑, 1,  
Total Targets: 156

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   lipid-P↓, 1,   MDA↓, 1,   ROS↓, 2,  

Cell Death ⓘ

JNK↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   cl‑eIF2α↑, 1,   GRP78/BiP↑, 1,   p‑PERK↑, 1,  

Functional Outcomes ⓘ

radioP↑, 1,   toxicity↓, 4,   toxicity↝, 1,  

Infection & Microbiome ⓘ

AntiViral↑, 1,  
Total Targets: 13

Scientific Paper Hit Count for: MMP, ΔΨm, mitochondrial membrane potential
4 Shikonin
3 Betulinic acid
3 Emodin
2 Silver-NanoParticles
2 Vitamin C (Ascorbic Acid)
2 Apigenin (mainly Parsley)
2 Radiotherapy/Radiation
2 Graviola
1 Ashwagandha(Withaferin A)
1 Baicalein
1 Berbamine
1 Bruteridin(bergamot juice)
1 Butyrate
1 Capsaicin
1 Chrysin
1 Dichloroacetate
1 EGCG (Epigallocatechin Gallate)
1 Fisetin
1 HydroxyTyrosol
1 Phenylbutyrate
1 Quercetin
1 salinomycin
1 Oxaliplatin
1 Silymarin (Milk Thistle) silibinin
1 Cisplatin
1 Selenite (Sodium)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:197  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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