MMP2 Cancer Research Results

MMP2, metalloproteinase-2: Click to Expand ⟱
Source:
Type:
Matrix metalloproteinase-2 (MMP-2) is an enzyme that plays a significant role in the degradation of extracellular matrix components, which is crucial for various physiological processes, including tissue remodeling, wound healing, and angiogenesis.
Elevated levels of MMP-2 have been associated with poor prognosis in various cancers, including breast, lung, and colorectal cancers.
MMP2 and MMP9: two enzymes are critical to tumor invasion.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
4559- AgNPs,    Anticancer activity of biogenerated silver nanoparticles: an integrated proteomic investigation
- in-vitro, BC, SkBr3 - in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116 - in-vitro, Colon, Caco-2
MMP2↓, MMP9↓, ROS↑, TumAuto↑, Apoptosis↑, ER Stress↑,
4812- ASTX,    Astaxanthin suppresses the metastasis of colon cancer by inhibiting the MYC-mediated downregulation of microRNA-29a-3p and microRNA-200a
- in-vitro, CRC, HCT116
miR-29b↑, miR-200b↑, MMP2↓, Zeb1↓, EMT↓, Apoptosis↑, ERK↓, MAPK↓, PI3K↓, Akt↓, MMPs↓, TumMeta↓,
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,
5868- CA,    Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HT29 - in-vitro, CRC, LoVo
Apoptosis↑, TumCMig↓, uPA↓, MMPs↓, COX2↓, TumCA↓, MMP9↓, MMP2↓, chemoPv↑,
6142- Cin,    Cinnamaldehyde affects the biological behavior of human colorectal cancer cells and induces apoptosis via inhibition of the PI3K/Akt signaling pathway
- in-vitro, CRC, LoVo - in-vitro, CRC, SW48 - in-vitro, CRC, HCT116
E-cadherin↑, MMP2↓, MMP9↓, PI3K↓, Akt↓, IGF-1↓, Apoptosis↑, BAX↑, cl‑PARP↑, PARP↓, Bcl-2↓, TumCI↓,
2974- CUR,    Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, CRC, HCT15 - in-vitro, CRC, COLO205 - in-vitro, CRC, SW-620 - in-vivo, NA, NA
TumCMig↓, TumCI↓, TumCG↓, TumMeta↓, Sp1/3/4↓, HDAC4↓, FAK↓, CD24↓, E-cadherin↑, EMT↓, TumCP↓, NF-kB↓, AP-1↝, STAT3↓, P53?, β-catenin/ZEB1↓, NOTCH1↝, Hif1a↝, PPARα↝, Rho↓, MMP2↓, MMP9↓,
811- GAR,    Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells
- in-vitro, CRC, HT-29
mPGES-1↓, Hif1a↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, Casp3↑, TumCP↓, PGE2↓,
1116- GI,    6-Shogaol Inhibits the Cell Migration of Colon Cancer by Suppressing the EMT Process Through the IKKβ/NF-κB/Snail Pathway
- in-vitro, Colon, Caco-2 - in-vitro, CRC, HCT116
TumCG↓, Apoptosis↑, TumCMig↓, MMP2↓, N-cadherin↓, IKKα↓, p‑NF-kB↓, Snail↓, VEGF↓,
1820- VitK3,    Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells
- in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
selectivity↑, TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Vim↓, Zeb1↓, MMP2↓, MMP9↓, TOPflash↓, β-catenin/ZEB1↓, p300↓, cycD1/CCND1↓, TumCCA↑,

Showing Research Papers: 1 to 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

CDC2↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↝, 1,   PPARα↝, 1,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↑, 5,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   MAPK↓, 1,   Telomerase↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   GRP78/BiP↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

P53?, 1,   PARP↓, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

CD24↓, 1,   EMT↓, 4,   ERK↓, 1,   HDAC4↓, 1,   IGF-1↓, 1,   mTOR↝, 1,   NOTCH1↝, 1,   p300↓, 1,   PI3K↓, 2,   STAT3↓, 1,   p‑STAT3↓, 1,   TOPflash↓, 1,   TumCG↓, 2,  

Migration ⓘ

AP-1↝, 1,   E-cadherin↓, 1,   E-cadherin↑, 3,   FAK↓, 1,   miR-200b↑, 1,   miR-29b↑, 1,   MMP2↓, 9,   MMP9↓, 7,   MMPs↓, 3,   N-cadherin↓, 2,   Rho↓, 1,   Snail↓, 1,   TumCA↓, 1,   TumCI↓, 4,   TumCMig↓, 5,   TumCP↓, 2,   TumMeta↓, 2,   uPA↓, 1,   Vim↓, 1,   Zeb1↓, 2,   ZO-1↑, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   Hif1a↓, 1,   Hif1a↝, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CXCR4↓, 1,   IKKα↓, 1,   p‑JAK2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 1,   p‑NF-kB↓, 1,   PGE2↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   eff↝, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   GutMicro↑, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,  
Total Targets: 78

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 6

Scientific Paper Hit Count for: MMP2, metalloproteinase-2
1 Silver-NanoParticles
1 Astaxanthin
1 Berberine
1 Carnosic acid
1 Cinnamon
1 Curcumin
1 Garcinol
1 Ginger/6-Shogaol/Gingerol
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:201  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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