TNF-α Cancer Research Results

TNF-α, TNF-α: Click to Expand ⟱
Source: HalifaxProj (block)
Type:
Tumor Necrosis Factor-alpha (TNF-α) is a cytokine that plays a complex role in cancer biology. It is primarily produced by activated macrophages and is involved in systemic inflammation. TNF-α is a pro-inflammatory cytokine that can promote inflammation, which is a known factor in cancer development.
Overall, the expression of TNF-α in cancers is often linked to inflammation, tumor progression, and the tumor microenvironment.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
743- Bor,    Boric Acid (Boron) Attenuates AOM-Induced Colorectal Cancer in Rats by Augmentation of Apoptotic and Antioxidant Mechanisms
- in-vitro, CRC, NA
BAX↑, Bcl-2↓, GPx↑, SOD↑, Catalase↑, MDA↓, TNF-α↓, IL6↓, IL10↑,
1080- Buty,    Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition
- in-vitro, CRC, HT-29
HDAC↓, TNF-α↓, COX2↓,
6007- CGA,    A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer
- Review, CRC, NA
antiOx↑, TumCCA↑, Apoptosis↑, Wnt↝, PI3K↝, MAPK↝, ROS↓, BioAv↝, P53↑, P21↑, CDK1↑, Ki-67↓, Ca+2↑, p‑Akt↓, mTOR↓, GSH↑, NRF2↑, HO-1↑, COX2↓, TNF-α↓, IL1β↓, IL6↓,
2521- H2,    Oxyhydrogen Gas: A Promising Therapeutic Approach for Lung, Breast and Colorectal Cancer
- Review, CRC, NA - Review, Lung, NA - Review, BC, NA
Inflam↑, ROS↓, ChemoSen↑, p‑PI3K↓, p‑Akt↓, QoL↑, GutMicro↑, chemoP↑, radioP↑, *NRF2↑, *Catalase↑, *GPx↑, *HO-1↑, *SOD↑, *TNF-α↓, *IL4↓, *IL6↓, ChemoSen↑, Appetite↑, cognitive↑, Pain↓, Sleep↑, other?,
5140- SAS,    Suppression of NF-κB activity by sulfasalazine is mediated by direct inhibition of IκB kinases α and β
- in-vitro, AML, Jurkat - in-vitro, CRC, SW-620
TNF-α↓, IKKα↓, NF-kB↓,
2361- SK,    Natural shikonin and acetyl-shikonin improve intestinal microbial and protein composition to alleviate colitis-associated colorectal cancer
- in-vivo, CRC, NA
GutMicro↑, Dose↝, IL1β↓, IL6↓, TNF-α↓, PKM2↓,
4889- ZER,    Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha
- in-vitro, CRC, HCT116
TumCP↓, TNF-α↓, *toxicity↝,

Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 2,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

PKM2↓, 1,  

Cell Death ⓘ

p‑Akt↓, 2,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   MAPK↝, 1,  

Transcription & Epigenetics ⓘ

other?, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↑, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   mTOR↓, 1,   PI3K↝, 1,   p‑PI3K↓, 1,   Wnt↝, 1,  

Migration ⓘ

Ca+2↑, 1,   Ki-67↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IKKα↓, 1,   IL10↑, 1,   IL1β↓, 2,   IL6↓, 3,   Inflam↑, 1,   NF-kB↓, 1,   TNF-α↓, 6,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   ChemoSen↑, 2,   Dose↝, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 2,   IL6↓, 3,   Ki-67↓, 1,  

Functional Outcomes ⓘ

Appetite↑, 1,   chemoP↑, 1,   cognitive↑, 1,   Pain↓, 1,   QoL↑, 1,   radioP↑, 1,   Sleep↑, 1,  
Total Targets: 49

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GPx↑, 1,   HO-1↑, 1,   NRF2↑, 1,   SOD↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL4↓, 1,   IL6↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

toxicity↝, 1,  
Total Targets: 10

Scientific Paper Hit Count for: TNF-α, TNF-α
1 Boron
1 Butyrate
1 Chlorogenic acid
1 Hydrogen Gas
1 Sulfasalazine
1 Shikonin
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:309  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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