IR Cancer Research Results

IR, Insulin Receptor pathway: Click to Expand ⟱
Source:
Type:
The Insulin/IR pathway is a major regulator of liver cells growth.
The pathway begins when insulin binds to the insulin receptor (IR), a transmembrane receptor that is part of the receptor tyrosine kinase family.
The insulin receptor pathway is a critical signaling pathway that regulates various cellular processes, including glucose metabolism, cell growth, and differentiation.

Negative Prognosis: In many cancers, overactivation of the insulin receptor pathway is associated with increased tumor aggressiveness, proliferation, and poorer overall survival. High levels of insulin or insulin receptor expression can correlate with worse clinical outcomes.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
446- CUR,    The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A Possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells
- in-vitro, CRC, SW480
IR↓, IGF-1↓, Myc↓, TumCMig↓, TumCP↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

IR↓, 1,  

Cell Death ⓘ

Myc↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1,  

Migration ⓘ

TumCMig↓, 1,   TumCP↓, 1,  

Clinical Biomarkers ⓘ

Myc↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IR, Insulin Receptor pathway
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:349  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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