IL8 Cancer Research Results

IL8, Interleukin-8: Click to Expand ⟱
Source:
Type:
Interleukin-8 (IL-8), also known as CXCL8, is a chemokine primarily involved in the recruitment and activation of neutrophils. Its role in cancer is significant, as it can influence tumor growth, metastasis, and the tumor microenvironment.
IL-8 is a chemokine frequently produced in the tumor microenvironment by human malignant cells. IL-8 plays key roles in the immunobiology of human malignancies and resistance to treatments. Circulating IL-8 concentration reflects tumor burden.

In many cancers have elevated levels of IL-8 and are associated with increased tumor aggressiveness, metastasis, and poorer overall survival. Elevated IL-8 often correlates with a more inflammatory tumor microenvironment, which can facilitate tumor progression.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
6309- Cro,    Crocin exerts anti-tumor effect in colon cancer cells via repressing the JaK pathway
- in-vitro, CRC, HCT116
tumCV↓, TumCP↓, Ki-67↓, Apoptosis↓, Inflam↓, ROS↑, MMP↓, JAK2↓, STAT3↓, ERK↓, MIP2↓, IL6↓, MCP1/CCL2↓, IL8↓, IL1β↓, TNF-α↓, SOD↓, Catalase↓, GSH↓, ROS↑, mtDam↑,
6303- Cro,    Crocetin treatment inhibits proliferation of colon cancer cells through down-regulation of genes involved in the inflammation
- in-vitro, CRC, HCT116 - in-vitro, CRC, DU145
NF-kB↓, VEGF↓, MMP9↓, Inflam↓, HMGB1↓, IL6↓, IL8↓, TumCG↓, Apoptosis↑,
6672- Deg,    Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice
- vitro+vivo, CRC, COLO205 - in-vitro, CRC, HCT116
Akt↑, AntiTum↑, IL8↓, p‑IKKα↓, NF-kB↓, TumCD↑, Apoptosis↑, cFLIP↓, Bcl-2↓, Bcl-xL↓, TumVol↓,
6356- Eug,  Cin,    Investigating the Molecular Mechanisms of the Anticancer Effects of Eugenol and Cinnamaldehyde Against Colorectal Cancer (CRC) Cells In Vitro
- in-vitro, CRC, SW-620 - in-vitro, CRC, Caco-2 - in-vitro, Nor, NCM460
P21↑, ChemoSen↑, Casp3↑, IL4↓, IL8↓, ROS↑, NRF2↑, HO-1↑, EMT↓,
7539- HT,    Polyphenols Extracts from Oil Production Waste Products (OPWPs) Reduce Cell Viability and Exert Anti-Inflammatory Activity via PPARγ Induction in Colorectal Cancer Cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, LoVo
tumCV↓, Apoptosis↑, TumCCA↑, p‑NF-kB↑, TNF-α↑, IL8↓, PPARγ↑, Inflam↓, Dose↝,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   GSH↓, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↑, 3,   SOD↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 3,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp3↑, 1,   cFLIP↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   ERK↓, 1,   STAT3↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,   MMP9↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,   p‑IKKα↓, 1,   IL1β↓, 1,   IL4↓, 1,   IL6↓, 2,   IL8↓, 5,   Inflam↓, 3,   JAK2↓, 1,   MCP1/CCL2↓, 1,   MIP2↓, 1,   NF-kB↓, 2,   p‑NF-kB↑, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 2,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   TumVol↓, 1,  
Total Targets: 48

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IL8, Interleukin-8
2 Crocetin
1 Deguelin
1 Eugenol
1 Cinnamon
1 HydroxyTyrosol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:368  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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