TCF Cancer Research Results

TCF, T-cell factor (Tcf) family: Click to Expand ⟱
Source:
Type:
T-cell factor (Tcf) is a family of transcription factors that play a crucial role in the Wnt signaling pathway, which is important for cell proliferation, differentiation, and survival. Tcf proteins, particularly Tcf1, Tcf3, Tcf4, and Tcf7L2, interact with β-catenin, a key mediator of Wnt signaling, to regulate the expression of target genes involved in various cellular processes.
Tcf factors are involved in maintaining the properties of cancer stem cells (CSCs), which are thought to drive tumor initiation, metastasis, and resistance to therapy. The Wnt/Tcf signaling pathway is often activated in CSCs, promoting their self-renewal and survival.
Tcf4: Often overexpressed due to mutations in the APC gene, leading to increased Wnt signaling and tumorigenesis
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
172- Api,    Apigenin suppresses colorectal cancer cell proliferation, migration and invasion via inhibition of the Wnt/β-catenin signaling pathway
- in-vitro, CRC, SW480 - in-vitro, CRC, HTC15
Wnt/(β-catenin)↓, TCF↓, LEF1↓, TumCP↓, TumCMig↓, TumCI↓,
449- CUR,    Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130a
- vitro+vivo, CRC, SW480
TumCP↓, β-catenin/ZEB1↓, TCF↓, miR-21↓, NKD2↑, miR-130a↓,
442- CUR,  5-FU,    Curcumin may reverse 5-fluorouracil resistance on colonic cancer cells by regulating TET1-NKD-Wnt signal pathway to inhibit the EMT progress
- in-vitro, CRC, HCT116
Apoptosis↑, TumCP↓, TumCCA↑, TET1↑, NKD2↑, Wnt↓, EMT↓, Vim↑, E-cadherin↓, β-catenin/ZEB1↓, TCF↓, AXIN1↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

miR-21↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

AXIN1↓, 1,   EMT↓, 1,   NKD2↑, 2,   TCF↓, 3,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

E-cadherin↓, 1,   LEF1↓, 1,   miR-130a↓, 1,   TET1↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 3,   Vim↑, 1,   β-catenin/ZEB1↓, 2,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TCF, T-cell factor (Tcf) family
2 Curcumin
1 Apigenin (mainly Parsley)
1 5-fluorouracil
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:414  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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