miR-130a Cancer Research Results

miR-130a, miR-130a microRNA: Click to Expand ⟱
Source:
Type: microRNA
MicroRNAs (miRNAs) are small non-coding RNAs that play a crucial role in regulating gene expression by binding to the 3' untranslated region (3' UTR) of target mRNAs, leading to their degradation or inhibition of translation.
miR-130a is overexpressed in several types of cancer: breast, lung, CRC, ovarian.
key targets of miR-130a: Tp53, PTEN, SMAD4, RUNX3.

miR-130a is generally considered protumorigenic in many contexts. Its ability to target and downregulate tumor suppressor genes can facilitate tumor growth, invasion, and metastasis.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
449- CUR,    Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via miR-130a
- vitro+vivo, CRC, SW480
TumCP↓, β-catenin/ZEB1↓, TCF↓, miR-21↓, NKD2↑, miR-130a↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics ⓘ

miR-21↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

NKD2↑, 1,   TCF↓, 1,  

Migration ⓘ

miR-130a↓, 1,   TumCP↓, 1,   β-catenin/ZEB1↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-130a, miR-130a microRNA
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:705  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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