4E-BP1 Cancer Research Results

4E-BP1, eukaryotic translation initiation factor 4E-binding protein 1: Click to Expand ⟱
Source:
Type: protein
4E-BP1 (eukaryotic translation initiation factor 4E-binding protein 1) is a protein that plays a crucial role in regulating cell growth, proliferation, and survival. It is a key downstream target of the mTOR (mechanistic target of rapamycin) signaling pathway, which is often dysregulated in cancer.
Phosphorylated and inactivated in: breast, lung, CRC, prostate, GBM, pancreatic, ovarian, melanoma, HCC.
The level of phosphorylation can impact the prognosis and treatment response.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
1008- Api,    Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
Wnt/(β-catenin)↓, β-catenin/ZEB1↓, TumAuto↑, Akt↓, mTOR↓, tumCV↓, TumCCA↑, TumAuto↑, p‑Akt↓, p‑p70S6↓, p‑4E-BP1↓,
965- SK,    Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1α signaling
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW-620
Hif1a↓, ROS↓, mTOR↓, p70S6↓, 4E-BP1↓, eIF2α↓, TumCCA↑, TumCP↓, Half-Life↝,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,  

Kinase & Signal Transduction ⓘ

p70S6↓, 1,   p‑p70S6↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

eIF2α↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 2,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   mTOR↓, 2,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

TumCP↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Drug Metabolism & Resistance ⓘ

Half-Life↝, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: 4E-BP1, eukaryotic translation initiation factor 4E-binding protein 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:736  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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