MIP2 Cancer Research Results

MIP2, Macrophage Inflammatory Protein 2: Click to Expand ⟱
Source:
Type: chemokine
Macrophage Inflammatory Protein 2 (MIP-2) is a chemokine that plays a role in the recruitment of immune cells to sites of inflammation.
MIP-2 is produced by various cell types, including macrophages, epithelial cells, and cancer cells themselves. It acts by binding to its receptors, CXCR1 and CXCR2, which are expressed on the surface of immune cells, such as neutrophils and macrophages.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
6309- Cro,    Crocin exerts anti-tumor effect in colon cancer cells via repressing the JaK pathway
- in-vitro, CRC, HCT116
tumCV↓, TumCP↓, Ki-67↓, Apoptosis↓, Inflam↓, ROS↑, MMP↓, JAK2↓, STAT3↓, ERK↓, MIP2↓, IL6↓, MCP1↓, IL8↓, IL1β↓, TNF-α↓, SOD↓, Catalase↓, GSH↓, ROS↑, mtDam↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   GSH↓, 1,   ROS↑, 2,   SOD↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,   mtDam↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   STAT3↓, 1,  

Migration ⓘ

Ki-67↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   IL6↓, 1,   IL8↓, 1,   Inflam↓, 1,   JAK2↓, 1,   MCP1↓, 1,   MIP2↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,   Ki-67↓, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MIP2, Macrophage Inflammatory Protein 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:788  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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