CXCR4 Cancer Research Results

CXCR4, Chemokine Receptor Type 4: Click to Expand ⟱
Source:
Type:
Chemokine Receptor Type 4 (CXCR4) is a G protein-coupled receptor that plays a significant role in various physiological processes, including immune responses, hematopoiesis, and organ development. It is also implicated in cancer biology, where it has been associated with tumor progression, metastasis, and the tumor microenvironment.
CXCR4 is often overexpressed in various types of cancers, including breast, lung, prostate, and pancreatic cancers. Its activation can promote tumor cell proliferation and survival.
-CXCR4 proteins associated with metastasis


CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
1169- Bos,    Boswellic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in Orthotopic Mouse Model By Downregulating Inflammatory, Proliferative, Invasive, and Angiogenic Biomarkers
- in-vivo, CRC, NA
TumCG↓, TumVol↓, Weight∅, ascitic↓, TumMeta↓, Ki-67↓, CD31↓, NF-kB↓, COX2↓, Bcl-2↓, Bcl-xL↓, IAP1↓, survivin↓, cycD1/CCND1↓, ICAM-1↓, MMP9↓, CXCR4↓, VEGF↓,
1422- Bos,    Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family
- in-vitro, CRC, NA - in-vivo, NA, NA
5LO↓, TumCG↓, Let-7↑, miR-200b↑, NF-kB↓, cMyc↓, cycD1/CCND1↓, MMP9↓, CXCR4↓, VEGF↓, Bcl-xL↓, survivin↓, IAP1↓, XIAP↓, TumCG↓, CDK6↓, Vim↓, E-cadherin↑,
811- GAR,    Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells
- in-vitro, CRC, HT-29
mPGES-1↓, Hif1a↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, Casp3↑, TumCP↓, PGE2↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

Bcl-2↓, 1,   Bcl-xL↓, 2,   Casp3↑, 1,   IAP1↓, 2,   survivin↓, 2,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 2,  

Proliferation, Differentiation & Cell State ⓘ

Let-7↑, 1,   TumCG↓, 3,  

Migration ⓘ

5LO↓, 1,   CD31↓, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   miR-200b↑, 1,   MMP2↓, 1,   MMP9↓, 3,   TumCP↓, 1,   TumMeta↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   VEGF↓, 3,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CXCR4↓, 3,   ICAM-1↓, 1,   mPGES-1↓, 1,   NF-kB↓, 2,   PGE2↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  

Clinical Biomarkers ⓘ

ascitic↓, 1,   Ki-67↓, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,   Weight∅, 1,  
Total Targets: 33

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CXCR4, Chemokine Receptor Type 4
2 Boswellia (frankincense)
1 Garcinol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:79  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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